DOI: 10.1111/j.1476-5381.1982.tb09210.x. ADENOSINE 5′‐DIPHOSPHATE ANTAGONISTS AND HUMAN PLATELETS: NO EVIDENCE THAT AGGREGATION AND INHIBITION OF STIMULATED ADENYLATE CYCLASE ARE MEDIATED BY DIFFERENT RECEPTORS

ADENOSINE 5′‐DIPHOSPHATE ANTAGONISTS AND HUMAN PLATELETS: NO EVIDENCE THAT AGGREGATION AND INHIBITION OF STIMULATED ADENYLATE CYCLASE ARE MEDIATED BY DIFFERENT RECEPTORS

10.1111/j.1476-5381.1982.tb09210.x

Crossref journal-article

Wiley

British Journal of Pharmacology (311)

Abstract

Adenosine 5′‐diphosphate (ADP) induces human platelet aggregation and noncompetitively inhibits stimulated human platelet adenylate cyclase; it has been suggested that these two effects are mediated by separate ADP receptors on the platelet surface. Adenosine 5′‐triphosphate and seven adenine nucleotide analogues were tested as inhibitors of both effects of ADP on human platelets, and were found to be competitive. pA2 values were calculated for each antagonist for inhibition of both effects of ADP, and a good correlation (correlation coefficient 0.87; P < 0.01) was found between the pA2 values for inhibition of ADP‐induced aggregation and the pA2 values for inhibition of the effect of ADP on stimulated adenylate cyclase. Such a correlation does not support the suggestion that ADP‐induced aggregation and the inhibition by ADP of stimulated adenylate cyclase are mediated by two separate receptors.

Bibliography

CUSACK, N. J., & HOURANI, S. M. O. (1982). ADENOSINE 5â²âDIPHOSPHATE ANTAGONISTS AND HUMAN PLATELETS: NO EVIDENCE THAT AGGREGATION AND INHIBITION OF STIMULATED ADENYLATE CYCLASE ARE MEDIATED BY DIFFERENT RECEPTORS. British Journal of Pharmacology, 76(1), 221â227. Portico.

Authors 2

N.J. CUSACK (first)
S.M.O. HOURANI (additional)

References 31 Referenced 66

10.1055/s-0038-1646664 / Thrombos. Haemostas. / Evaluation of platelet tests for measurement of cell integrity by AKKERMAN J.W.N (1978)
10.1111/j.1476-5381.1959.tb00928.x
10.1016/S0021-9258(17)34507-6 / J. biol. Chem. / Identification of adenine nucleotide binding proteins in human platelet membranes by affinity labeling with 5′‐p‐fluorosulfonylbenzoyl adenosine by BENNETT J.S. (1978)
10.1038/194927b0
10.1111/j.1476-5381.1977.tb09743.x
10.1111/j.1476-5381.1972.tb07244.x
10.1073/pnas.75.10.4798
{'key': 'e_1_2_1_8_1', 'first-page': '62', 'article-title': 'Platelet nucleotide metabolism and platelet aggregation', 'volume': '3', 'author': 'CHAMBERS D.A.', 'year': '1968', 'journal-title': 'Exp. Biol. Med.'} / Exp. Biol. Med. / Platelet nucleotide metabolism and platelet aggregation by CHAMBERS D.A. (1968)
10.1111/j.1476-5381.1981.tb10437.x
10.1111/j.1476-5381.1982.tb08800.x
10.1021/bi00653a015
{'key': 'e_1_2_1_12_1', 'first-page': '101', 'article-title': 'Inhibition of ADP‐induced aggregation of human platelets by β,γ‐methylene‐ATP', 'volume': '23', 'author': 'EVANS P.M.', 'year': '1979', 'journal-title': 'Cytobios.'} / Cytobios. / Inhibition of ADP‐induced aggregation of human platelets by β,γ‐methylene‐ATP by EVANS P.M. (1979)
10.1021/jm00303a604
10.1021/jm00268a028
10.1021/jm00204a004
10.1021/bi00765a020
10.1016/0014-5793(75)81067-2
{'key': 'e_1_2_1_18_1', 'first-page': '333', 'article-title': 'Interactions of the pharmacological receptors of blood platelets with adenylate cyclase', 'author': 'HASLAM R.J.', 'year': '1973', 'journal-title': 'Ser. Haemat.'} / Ser. Haemat. / Interactions of the pharmacological receptors of blood platelets with adenylate cyclase by HASLAM R.J. (1973)
10.1007/978-94-009-5816-6_7
{'key': 'e_1_2_1_20_1', 'first-page': '528', 'article-title': 'Effects of adenosine on levels of adenosine cyclic 3′,5′‐monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation', 'volume': '11', 'author': 'HASLAM R.J.', 'year': '1975', 'journal-title': 'Molec. Pharmac.'} / Molec. Pharmac. / Effects of adenosine on levels of adenosine cyclic 3′,5′‐monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation by HASLAM R.J. (1975)
10.1111/j.1600-0609.1975.tb01060.x
10.1016/0304-4165(80)90394-3
10.1182/blood.V46.3.309.309 / Blood / The effects of ATP on platelets: evidence against the central role of released ADP in primary aggregation by MACFARLANE D.E. (1975)
{'key': 'e_1_2_1_24_1', 'first-page': '185', 'article-title': '2‐Methylthio‐adenosine‐5′‐diphosphate (2MeSADP), a high affinity probe for ADP receptors on the human platelet', 'volume': '42', 'author': 'MACFARLANE D.E.', 'year': '1979', 'journal-title': 'Thrombos. Haemostas.'} / Thrombos. Haemostas. / 2‐Methylthio‐adenosine‐5′‐diphosphate (2MeSADP), a high affinity probe for ADP receptors on the human platelet by MACFARLANE D.E. (1979)
{'key': 'e_1_2_1_25_1', 'first-page': '83', 'article-title': 'Specific inhibition of ADP‐induced platelet responses by 2‐n‐amylthio AMP', 'volume': '38', 'author': 'MACINTYRE D.E.', 'year': '1977', 'journal-title': 'Thrombos. Haemostas.'} / Thrombos. Haemostas. / Specific inhibition of ADP‐induced platelet responses by 2‐n‐amylthio AMP by MACINTYRE D.E. (1977)
{'key': 'e_1_2_1_26_1', 'first-page': '220', 'article-title': 'Effect of the rapid shape change of platelets on the transmission and scattering of light through plasma', 'volume': '231', 'author': 'MICHAL F.', 'year': '1971', 'journal-title': 'Nature'} / Nature / Effect of the rapid shape change of platelets on the transmission and scattering of light through plasma by MICHAL F. (1971)
10.1038/2221073a0
{'key': 'e_1_2_1_28_1', 'first-page': '1619', 'article-title': 'Evidence for two separate receptors mediating the actions of ADP on human platelets', 'volume': '39', 'author': 'MILLS D.C.B.', 'year': '1980', 'journal-title': 'Fedn Proc.'} / Fedn Proc. / Evidence for two separate receptors mediating the actions of ADP on human platelets by MILLS D.C.B. (1980)
{'key': 'e_1_2_1_29_1', 'first-page': '82', 'article-title': 'Attempts to define a platelet ADP receptor with 203Hg‐p‐mercuribenzene sulphonate (MBS)', 'volume': '38', 'author': 'MILLS D.C.B.', 'year': '1977', 'journal-title': 'Thrombos. Haemostas.'} / Thrombos. Haemostas. / Attempts to define a platelet ADP receptor with 203Hg‐p‐mercuribenzene sulphonate (MBS) by MILLS D.C.B. (1977)
{'key': 'e_1_2_1_30_1', 'first-page': '546', 'article-title': '2 Azido ADP‐a photolabile probe for the ADP receptor on platelets', 'volume': '37', 'author': 'MILLS D.C.B.', 'year': '1978', 'journal-title': 'Fedn Proc.'} / Fedn Proc. / 2 Azido ADP‐a photolabile probe for the ADP receptor on platelets by MILLS D.C.B. (1978)
10.1007/978-1-4684-6265-4

Dates

Type	When
Created	13 years, 1 month ago (July 20, 2012, 2:38 a.m.)
Deposited	1 year, 9 months ago (Nov. 4, 2023, 2:08 p.m.)
Indexed	4 months, 3 weeks ago (April 8, 2025, 7:05 p.m.)
Issued	43 years, 4 months ago (May 1, 1982)
Published	43 years, 4 months ago (May 1, 1982)
Published Online	13 years, 1 month ago (July 19, 2012)
Published Print	43 years, 4 months ago (May 1, 1982)

Funders 0

None

BibTeX

@article{CUSACK_1982, title={ADENOSINE 5′‐DIPHOSPHATE ANTAGONISTS AND HUMAN PLATELETS: NO EVIDENCE THAT AGGREGATION AND INHIBITION OF STIMULATED ADENYLATE CYCLASE ARE MEDIATED BY DIFFERENT RECEPTORS}, volume={76}, ISSN={1476-5381}, url={http://dx.doi.org/10.1111/j.1476-5381.1982.tb09210.x}, DOI={10.1111/j.1476-5381.1982.tb09210.x}, number={1}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={CUSACK, N.J. and HOURANI, S.M.O.}, year={1982}, month=may, pages={221–227} }

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