DOI: 10.1111/j.1476-5381.1976.tb08625.x. ON THE FUNCTIONAL COUPLING OF NEUROTRANSMITTER UPTAKE AND RELEASE IN BRAIN

ON THE FUNCTIONAL COUPLING OF NEUROTRANSMITTER UPTAKE AND RELEASE IN BRAIN

10.1111/j.1476-5381.1976.tb08625.x

Crossref journal-article

Wiley

British Journal of Pharmacology (311)

Abstract

Isolated synaptosomal fractions from mouse forebrains were incubated with [14C]‐γ‐aminobutyric acid ([14C]‐GABA). Release of the accumulated label in high potassium solution was measured. The fractional release dependent upon calcium was decreased by raising the concentration of [14C]‐GABA during labelling but was not affected by altering the time allowed for labelling or the time between labelling and stimulation. These data suggest that extracellular GABA gains rapid access to available intraterminal pools. The relative distribution of the accumulated GABA in different pools can be influenced by the concentration of GABA in the incubation medium but, once ‘stored’, there is no net redistribution of accumulated GABA in the absence of stimulation.

Bibliography

COTMAN, C. W., HAYCOCK, J. W., & LEVY, W. B. (1976). ON THE FUNCTIONAL COUPLING OF NEUROTRANSMITTER UPTAKE AND RELEASE IN BRAIN. British Journal of Pharmacology, 58(4), 569â572. Portico.

Authors 3

C.W. COTMAN (first)
J.W. HAYCOCK (additional)
W.B. LEVY (additional)

References 14 Referenced 14

10.1111/j.1471-4159.1972.tb01376.x
10.1111/j.1471-4159.1972.tb06229.x
10.1016/S0024-3205(74)80002-0
10.1073/pnas.69.8.2237
10.1113/jphysiol.1976.sp011241
10.1111/j.1476-5381.1973.tb08342.x
10.1111/j.1476-5381.1974.tb10672.x
10.1111/j.1476-5381.1971.tb07066.x
10.1016/0024-3205(73)90110-0
{'key': 'e_1_2_1_11_1', 'first-page': '438', 'article-title': 'Effects of polyvalent cations on stimulus‐secretion coupling of 14C‐GABA from isolated brain synaptosomes', 'volume': '10', 'author': 'Levy W.B.', 'year': '1974', 'journal-title': 'Molec. Pharmac.'} / Molec. Pharmac. / Effects of polyvalent cations on stimulus‐secretion coupling of 14C‐GABA from isolated brain synaptosomes by Levy W.B. (1974)
10.1016/0006-8993(76)90510-2
10.1126/science.181.4100.676
10.1038/258254a0
10.1111/j.1471-4159.1975.tb04370.x

Dates

Type	When
Created	13 years, 1 month ago (July 20, 2012, 2:12 a.m.)
Deposited	1 year, 10 months ago (Nov. 4, 2023, 9:39 a.m.)
Indexed	1 year, 9 months ago (Nov. 4, 2023, 8:14 p.m.)
Issued	48 years, 9 months ago (Dec. 1, 1976)
Published	48 years, 9 months ago (Dec. 1, 1976)
Published Online	13 years, 1 month ago (July 19, 2012)
Published Print	48 years, 9 months ago (Dec. 1, 1976)

Funders 0

None

BibTeX

@article{COTMAN_1976, title={ON THE FUNCTIONAL COUPLING OF NEUROTRANSMITTER UPTAKE AND RELEASE IN BRAIN}, volume={58}, ISSN={1476-5381}, url={http://dx.doi.org/10.1111/j.1476-5381.1976.tb08625.x}, DOI={10.1111/j.1476-5381.1976.tb08625.x}, number={4}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={COTMAN, C.W. and HAYCOCK, J.W. and LEVY, W.B.}, year={1976}, month=dec, pages={569–572} }

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