DOI: 10.1111/j.1476-5381.1976.tb07710.x. GLUTAMATE ANTAGONISTS IN RAT HIPPOCAMPUS

GLUTAMATE ANTAGONISTS IN RAT HIPPOCAMPUS

10.1111/j.1476-5381.1976.tb07710.x

Crossref journal-article

Wiley

British Journal of Pharmacology (311)

Abstract

Hippocampal cellular responses to acidic amino acids and some of their antagonists were measured in the rat anaesthetized with urethane. The effects of these antagonists on the field responses of the rat hippocampus to afferent stimulation were measured in acute as well as chronically prepared rats. Hippocampal pyramidal cells were excited by microiontophoretic application of glutamate and aspartate. These responses were antagonized by glutamic acid diethyl ester (GDEE), glutamic acid dimethyl ester (GDME) and by proline. Partial specificity could be seen as excitatory responses to acetylcholine were less susceptible to the antagonists. Field responses of the hippocampus to commissural stimulation were reduced significantly in both an acutely prepared or the conscious rat following parenteral administration of GDEE and GDME but not proline. Responses to perforant path stimulation were not affected by these drugs. It is suggested that an acidic amino acid may serve as a neurotransmitter in the commissural path to area CA1 of the dorsal hippocampus.

Bibliography

SEGAL, M. (1976). GLUTAMATE ANTAGONISTS IN RAT HIPPOCAMPUS. British Journal of Pharmacology, 58(3), 341â345. Portico.

Authors 1

M. SEGAL (first)

References 15 Referenced 73

10.1111/j.1748-1716.1960.tb01856.x
10.1113/jphysiol.1966.sp007869
{'key': 'e_1_2_1_4_1', 'first-page': '696', 'article-title': 'Glutamate in the cat hippocampus: Distribution and release', 'volume': '32', 'author': 'CRAWFORD I.L.', 'year': '1973', 'journal-title': 'Fedn Proc.'} / Fedn Proc. / Glutamate in the cat hippocampus: Distribution and release by CRAWFORD I.L. (1973)
10.1016/0006-8993(72)90503-3
10.1007/BF00586233
{'key': 'e_1_2_1_7_1', 'first-page': '430', 'article-title': 'An improved constant current source for microiontophoretic drug application studies', 'volume': '33', 'author': 'GELLER H.M.', 'year': '1972', 'journal-title': 'EEG J.'} / EEG J. / An improved constant current source for microiontophoretic drug application studies by GELLER H.M. (1972)
10.1016/0006-8993(72)90470-2
10.1016/0006-8993(73)90081-4
{'key': 'e_1_2_1_10_1', 'first-page': '22A', 'article-title': 'Uptake of 3H‐glutamate in excitatory nerve endings in the hippocampal formation of the rat', 'volume': '96', 'author': 'IVERSEN L.L.', 'year': '1976', 'journal-title': 'Acta physiol. scand.'} / Acta physiol. scand. / Uptake of 3H‐glutamate in excitatory nerve endings in the hippocampal formation of the rat by IVERSEN L.L. (1976)
10.1016/0006-8993(72)90343-5
NADLER J. VACA K. COTMAN C.W.&LYNCH G.S.(1975).Calcium dependent efflux of aspartate glutamate and GABA from rat hippocampal formation: effects of selective lesions.5th Neuroscience Meeting Abstracts New York 400.
10.1152/jn.1973.36.5.840 / J. Neurophysiol. / Flow of conditioned responses in the limbic telencephalic system of the rat by SEGAL M. (1973)
10.1016/0006-8993(76)90594-1
10.1113/jphysiol.1973.sp010306
10.1111/j.1471-4159.1973.tb00065.x

Dates

Type	When
Created	13 years, 1 month ago (July 19, 2012, 3:37 p.m.)
Deposited	1 year, 10 months ago (Oct. 6, 2023, 7:34 p.m.)
Indexed	1 year, 9 months ago (Nov. 12, 2023, 7:51 a.m.)
Issued	48 years, 9 months ago (Nov. 1, 1976)
Published	48 years, 9 months ago (Nov. 1, 1976)
Published Online	13 years, 1 month ago (July 19, 2012)
Published Print	48 years, 9 months ago (Nov. 1, 1976)

Funders 0

None

BibTeX

@article{SEGAL_1976, title={GLUTAMATE ANTAGONISTS IN RAT HIPPOCAMPUS}, volume={58}, ISSN={1476-5381}, url={http://dx.doi.org/10.1111/j.1476-5381.1976.tb07710.x}, DOI={10.1111/j.1476-5381.1976.tb07710.x}, number={3}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={SEGAL, M.}, year={1976}, month=nov, pages={341–345} }

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