DOI: 10.1111/j.1476-5381.1976.tb07643.x. BENZODIAZEPINES AND CENTRAL GLYCINE RECEPTORS

BENZODIAZEPINES AND CENTRAL GLYCINE RECEPTORS

10.1111/j.1476-5381.1976.tb07643.x

Crossref journal-article

Wiley

British Journal of Pharmacology (311)

Abstract

In cats, anaesthetized with pentobarbitone, intravenous diazepam (minimum dose 3.0 mg/kg) enhanced dorsal root potentials but did not significantly diminish the reduction by electrophoretic strychnine of the inhibitory action of electrophoretic glycine on dorsal horn interneurones. In mice, intraperitoneal diazepam (2.5 mg/kg) had no appreciable effect on the potency of strychnine as a convulsant, although providing some protection against bicuculline. These observations, together with the failure of chlordiazepoxide to either inhibit the firing of spinal interneurones or reduce antagonism between strychnine and glycine when administered locally, provide no support for the interaction between benzodiazepines and mammalian central glycine receptors which has been proposed on the basis of in vitro studies of strychnine binding.

Bibliography

CURTIS, D. R., GAME, C. J. A., & LODGE, D. (1976). BENZODIAZEPINES AND CENTRAL GLYCINE RECEPTORS. British Journal of Pharmacology, 56(3), 307â311. Portico.

Authors 3

D.R. CURTIS (first)
C.J.A. GAME (additional)
D. LODGE (additional)

References 11 Referenced 54

10.1016/0024-3205(75)90501-9
10.1016/0006-8993(71)90156-9
{'key': 'e_1_2_1_4_1', 'first-page': '97', 'article-title': 'Amino acid transmitters in the mammalian central nervous system', 'volume': '69', 'author': 'Curtis D.R.', 'year': '1974', 'journal-title': 'Ergebn. Physiol.'} / Ergebn. Physiol. / Amino acid transmitters in the mammalian central nervous system by Curtis D.R. (1974)
10.1007/BF00504702
{'key': 'e_1_2_1_6_1', 'first-page': '162', 'article-title': 'Antagonism of bicuculline and Ro 5–3663 by diazepam', 'volume': '15', 'author': 'Schlosser W.', 'year': '1973', 'journal-title': 'Pharmacologist'} / Pharmacologist / Antagonism of bicuculline and Ro 5–3663 by diazepam by Schlosser W. (1973)
10.1007/BFb0047741
10.1007/BF00535931
10.1111/j.1476-5381.1975.tb07383.x
10.1073/pnas.70.10.2832
10.1073/pnas.71.6.2246
10.1016/S1054-3589(08)60658-4

Dates

Type	When
Created	13 years, 1 month ago (July 19, 2012, 9:51 a.m.)
Deposited	1 year, 9 months ago (Nov. 4, 2023, 6:44 a.m.)
Indexed	1 year, 1 month ago (July 24, 2024, 4 p.m.)
Issued	49 years, 6 months ago (March 1, 1976)
Published	49 years, 6 months ago (March 1, 1976)
Published Online	13 years, 1 month ago (July 19, 2012)
Published Print	49 years, 6 months ago (March 1, 1976)

Funders 0

None

BibTeX

@article{CURTIS_1976, title={BENZODIAZEPINES AND CENTRAL GLYCINE RECEPTORS}, volume={56}, ISSN={1476-5381}, url={http://dx.doi.org/10.1111/j.1476-5381.1976.tb07643.x}, DOI={10.1111/j.1476-5381.1976.tb07643.x}, number={3}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={CURTIS, D.R. and GAME, C.J.A. and LODGE, D.}, year={1976}, month=mar, pages={307–311} }

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