DOI: 10.1111/j.1476-5381.1972.tb08116.x. Acetylcholine inhibition in the intact and chronically isolated cerebral cortex

Acetylcholine inhibition in the intact and chronically isolated cerebral cortex

10.1111/j.1476-5381.1972.tb08116.x

Crossref journal-article

Wiley

British Journal of Pharmacology (311)

Abstract

Summary Some spontaneously firing cells in the cerebral cortex of cats can be depressed by iontophoretically applied acetylcholine or acetyl‐β‐methylcholine, and this depression is antagonized by atropine. Thirteen per cent of 101 spontaneously active neurones tested were depressed by cholinergic agents and 64% were excited. Single stimuli applied to the adjacent cortical surface excited 132 neurones orthodromically. Acetylcholine or acetyl‐β‐methylcholine depressed this synaptic firing in 18% of the cells. The depression was blocked by atropine. The population of neurones in which cholinergic agents depressed spontaneous or synaptic firing was located within the superficial half of the cortex. Glutamate‐induced firing was depressed by cholinergic agents in 41% of 211 cells tested; atropine and strychnine strongly antagonized this depressant action, while dihydro‐β‐erythroidine was a weaker antagonist. Long duration inhibition of glutamate‐induced firing evoked by repetitive stimulation of the cortical surface could be blocked by atropine or strychnine in both the intact and chronically isolated cortex. This provides strong evidence for a system of intracortical cholinergic neurones which make direct inhibitory contacts with neurones in the superficial layers of the cortex.

Bibliography

JORDAN, L. M., & PHILLIS, J. W. (1972). Acetylcholine inhibition in the intact and chronically isolated cerebral cortex. British Journal of Pharmacology, 45(4), 584â595. Portico.

Authors 2

L. M. JORDAN (first)
J. W. PHILLIS (additional)

References 34 Referenced 52

10.1111/j.1476-5381.1970.tb10606.x
10.1111/j.1476-5381.1969.tb09528.x
10.1016/0013-4694(55)90080-8
10.1016/0013-4694(54)90030-9
10.1113/jphysiol.1967.sp008125
10.1016/0028-3908(70)90045-6
10.1016/0006-8993(70)90083-1
10.1113/jphysiol.1966.sp008024
10.1139/y71-001
10.1016/0024-3205(70)90203-1
10.1016/S0031-6989(69)80136-0
10.1016/0028-3908(69)90072-0
10.1016/0013-4694(71)90253-7
10.1113/jphysiol.1963.sp007057
10.1113/jphysiol.1963.sp007106
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{'key': 'e_1_2_1_23_1', 'first-page': '711', 'article-title': 'A histochemical study of cholinergic fibers in the cerebral cortex', 'volume': '99', 'author': 'Krnjević K.', 'year': '1965', 'journal-title': 'J. Anat.'} / J. Anat. / A histochemical study of cholinergic fibers in the cerebral cortex by Krnjević K. (1965)
10.1007/BF02324767
10.1111/j.1471-4159.1968.tb08969.x
10.1152/jn.1971.34.3.374 / J. Neurophysiol. / Occlusive behavior of negative‐wave direct cortical response (DCR) and single cells in the cortex by Phillis J. W. (1971)
10.1016/0006-8993(67)90025-X
10.1038/216922a0
10.1016/0024-3205(68)90362-7
10.1016/0006-8993(68)90201-1
10.1016/0014-4886(64)90020-2
Sastry P. B.(1956).The Functional Significance of Acetylcholine in the Brain.Doctoral Dissertation McGill University Montreal.
10.1093/brain/90.3.497
10.1016/0014-4886(70)90065-8
10.1016/0014-4886(69)90080-6

Dates

Type	When
Created	13 years, 1 month ago (July 20, 2012, 7:03 a.m.)
Deposited	1 year, 10 months ago (Nov. 4, 2023, 8:07 a.m.)
Indexed	1 year, 9 months ago (Nov. 12, 2023, 2:53 a.m.)
Issued	53 years, 1 month ago (Aug. 1, 1972)
Published	53 years, 1 month ago (Aug. 1, 1972)
Published Online	13 years, 1 month ago (July 19, 2012)
Published Print	53 years, 1 month ago (Aug. 1, 1972)

Funders 0

None

BibTeX

@article{JORDAN_1972, title={Acetylcholine inhibition in the intact and chronically isolated cerebral cortex}, volume={45}, ISSN={1476-5381}, url={http://dx.doi.org/10.1111/j.1476-5381.1972.tb08116.x}, DOI={10.1111/j.1476-5381.1972.tb08116.x}, number={4}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={JORDAN, L. M. and PHILLIS, J. W.}, year={1972}, month=aug, pages={584–595} }

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