DOI: 10.1111/j.1476-5381.1970.tb10591.x. The isolation of human plasma prekallikrein

The isolation of human plasma prekallikrein

10.1111/j.1476-5381.1970.tb10591.x

Crossref journal-article

Wiley

British Journal of Pharmacology (311)

Abstract

Summary . The isolation of human plasma prekallikrein was achieved by fractionating human plasma on diethylaminoethyl cellulose (DEAE) in the presence of heparin. . Heparin was shown to inhibit the activation of prekallikrein during the isolation procedure. . The isolated prekallikrein fraction had some kallikrein activity which could be inhibited by diisopropylfluorophosphate (DFP) without affecting the ability of prekallikrein to be activated. . The prekallikrein obtained was functionally pure in that it had no kallikrein inhibiting or activating activity. It was not physico‐chemically pure, the major contaminant being the immunoglobulin IgG.

Bibliography

McCONNELL, D. J., & MASON, B. (1970). The isolation of human plasma prekallikrein. British Journal of Pharmacology, 38(3), 490â502. Portico.

Authors 2

D. J. McCONNELL (first)
BRENDA MASON (additional)

References 29 Referenced 18

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10.1113/jphysiol.1963.sp007119
10.1111/j.1476-5381.1964.tb01546.x
{'key': 'e_1_2_1_9_1', 'first-page': '335', 'article-title': 'Enzyme‐like globulins from serum reproducing the vascular phenomenon of inflammation. V. Activable permeability factor in human serum', 'volume': '39', 'author': 'Elder J. M.', 'year': '1958', 'journal-title': 'Br. J. exp. Path'} / Br. J. exp. Path / Enzyme‐like globulins from serum reproducing the vascular phenomenon of inflammation. V. Activable permeability factor in human serum by Elder J. M. (1958)
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{'key': 'e_1_2_1_19_1', 'first-page': '35', 'article-title': 'A pendulum auxotonic lever', 'volume': '137', 'author': 'Paton W. D. M.', 'year': '1957', 'journal-title': 'J. Physiol. Lond'} / J. Physiol. Lond / A pendulum auxotonic lever by Paton W. D. M. (1957)
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{'key': 'e_1_2_1_21_1', 'first-page': '328', 'article-title': 'The induction of permeability‐increasing activity in human plasma by activated Hageman factor', 'volume': '45', 'author': 'Ratnoff O. D.', 'year': '1964', 'journal-title': 'Br. J. exp. Path'} / Br. J. exp. Path / The induction of permeability‐increasing activity in human plasma by activated Hageman factor by Ratnoff O. D. (1964)
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{'key': 'e_1_2_1_29_1', 'first-page': '228', 'article-title': 'Enzyme‐like globulins from serum reproducing the vascular phenomena of inflammation. IV. Activable permeability factor and its inhibitor in the serum of the rat and the rabbit', 'volume': '39', 'author': 'Wilhelm D. L.', 'year': '1958', 'journal-title': 'Br. J. exp. Path'} / Br. J. exp. Path / Enzyme‐like globulins from serum reproducing the vascular phenomena of inflammation. IV. Activable permeability factor and its inhibitor in the serum of the rat and the rabbit by Wilhelm D. L. (1958)
{'key': 'e_1_2_1_30_1', 'first-page': '363', 'article-title': 'Rabbit plasma kininogenase', 'volume': '28', 'author': 'Wuepper K. D.', 'year': '1969', 'journal-title': 'Fedn Proc'} / Fedn Proc / Rabbit plasma kininogenase by Wuepper K. D. (1969)

Dates

Type	When
Created	13 years, 1 month ago (July 19, 2012, 8:26 p.m.)
Deposited	1 year, 9 months ago (Nov. 4, 2023, 4:27 a.m.)
Indexed	1 year, 9 months ago (Nov. 4, 2023, 8:14 p.m.)
Issued	55 years, 5 months ago (March 1, 1970)
Published	55 years, 5 months ago (March 1, 1970)
Published Online	13 years, 1 month ago (July 19, 2012)
Published Print	55 years, 5 months ago (March 1, 1970)

Funders 0

None

BibTeX

@article{McCONNELL_1970, title={The isolation of human plasma prekallikrein}, volume={38}, ISSN={1476-5381}, url={http://dx.doi.org/10.1111/j.1476-5381.1970.tb10591.x}, DOI={10.1111/j.1476-5381.1970.tb10591.x}, number={3}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={McCONNELL, D. J. and MASON, BRENDA}, year={1970}, month=mar, pages={490–502} }

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