DOI: 10.1111/j.1476-5381.1969.tb10577.x. Effects of monoamine oxidase inhibitors on the hypothermia produced in cats by halothane

Effects of monoamine oxidase inhibitors on the hypothermia produced in cats by halothane

10.1111/j.1476-5381.1969.tb10577.x

Crossref journal-article

Wiley

British Journal of Pharmacology (311)

Abstract

. In cats, the effects of intraperitoneal injections of four monoamine oxidase (MAO) inhibitors, tranylcypromine, pheniprazine, pargyline, and nialamide, were examined on rectal temperature and on the hypothermia during anaesthesia produced by a 2 hr period of halothane inhalation.. A 2 hr period of halothane inhalation produced a steady fall in temperature amounting to between 2° and 3·5° C. After discontinuation of halothane inhalation, temperature quickly returned to the pre‐anaesthetic level but no pyrexia developed. A peculiar stiffness of the leg muscles occurred in several experiments either at the beginning of the inhalation or after its discontinuation.. An injection of tranylcypromine (5 mg/kg) caused a rise in rectal temperature and prevented the hypothermia of halothane anaesthesia. This effect lasted for at least 4 hr; 20 hr after the injection, halothane again caused hypothermia.. An injection of pheniprazine (10 mg/kg) usually caused a small rise in temperature which was not sustained. Pheniprazine not only prevented the hypothermia of halothane anaesthesia during the subsequent 20 hr, but during the first few hours after the injection halothane inhalation actually produced a steep rise in temperature.. An injection of pargyline (50 mg/kg) had no effect on temperature but the hypothermia due to halothane inhalation was prevented 1 hr after the injection and attenuated after 20 hr. Injection of 200 mg/kg caused a steady rise in temperature which was accelerated when halothane was administered 1 hr later.. An injection of nialamide (10, 25 or 50 mg/kg) had no immediate effect on temperature, but pyrexia developed overnight after the two larger doses. The effect on the hypothermia due to halothane inhalation was greater 20 hr after the injection than it was after 1 to 2 hr. Twenty hours after injection of the two larger doses, halothane no longer produced hypothermia but caused a lethal rise in temperature either during or after its inhalation.. In rabbits, the effect on temperature of halothane inhalation varied. Either temperature rose slightly or it fell, but not as much as in cats. In one rabbit in which the inhalation had produced a transient rise, pyrexia developed 40 min after discontinuation of halothane.

Bibliography

SUMMERS, R. J. (1969). Effects of monoamine oxidase inhibitors on the hypothermia produced in cats by halothane. British Journal of Pharmacology, 37(2), 400â413. Portico.

Authors 1

R. J. SUMMERS (first)

References 33 Referenced 13

10.1111/j.1749-6632.1959.tb49239.x
10.1136/bmj.2.4903.1526
10.1113/jphysiol.1965.sp007801
10.1007/BF03003609
10.1007/BF03003611
10.1113/jphysiol.1967.sp008129
10.1113/jphysiol.1967.sp008264
10.1113/jphysiol.1967.sp008202
10.1113/jphysiol.1964.sp007454
10.1113/jphysiol.1964.sp007527
10.1111/j.1749-6632.1962.tb50123.x
10.1001/jama.1964.03070180054008
10.1016/S0022-3565(25)25687-7 / J. Pharmac. exp. Ther / Effects of several monoamine oxidase inhibitors on cardiovascular actions of naturally occurring amines in dog by Goldberg L. I. (1959)
10.1111/j.1476-5381.1969.tb09525.x
10.1136/bmj.3.5618.594
10.1136/bmj.4.5633.750
10.1007/BF03003608
10.1136/bmj.3.5621.803-d
{'key': 'e_1_2_1_20_1', 'first-page': '840', 'article-title': 'Symposium on monoamine oxidase inhibitors', 'volume': '80', 'author': 'Kinross‐Wright J.', 'year': '1959', 'journal-title': 'Ann. N.Y. Acad. Sci'} / Ann. N.Y. Acad. Sci / Symposium on monoamine oxidase inhibitors by Kinross‐Wright J. (1959)
10.1007/BF03003610
10.1016/S0022-3565(25)26090-6 / J. Pharmac. exp. Ther / Cardiac activities of several monoamine‐oxidase inhibitors by Lee W. C. (1961)
10.1007/BF03003718
10.1007/BF03003606
10.1097/00000542-195507000-00021
{'key': 'e_1_2_1_26_1', 'first-page': '1748', 'article-title': "Variations interspécifiques des modifications de la température centrale liées a l'injection cérébro‐ventriculaire de catecholamines et de 5‐hydroxytryptamine", 'volume': '159', 'author': 'Ruckebusch Y.', 'year': '1965', 'journal-title': 'C.r. Séanc. Soc. Biol'} / C.r. Séanc. Soc. Biol / Variations interspécifiques des modifications de la température centrale liées a l'injection cérébro‐ventriculaire de catecholamines et de 5‐hydroxytryptamine by Ruckebusch Y. (1965)
10.1001/jama.1964.03070250011002
10.1111/j.1749-6632.1963.tb13335.x
10.1111/j.1749-6632.1963.tb13329.x
{'key': 'e_1_2_1_30_1', 'first-page': '277', 'article-title': 'Observations on cardiovascular effects of tranylcypromine', 'volume': '19', 'author': 'Spencer J. N.', 'year': '1960', 'journal-title': 'Fedn Proc'} / Fedn Proc / Observations on cardiovascular effects of tranylcypromine by Spencer J. N. (1960)
10.1001/jama.1967.03130160052008 / J. Am. med. Ass / Fulminant hyperthermia during anaesthesia and surgery by Stephen C. R. (1967)
10.1007/BF03003607
10.1016/S0031-6997(25)07427-7 / Pharmac. Rev / Catecholamines in brain by Vogt M. (1959)
10.1001/jama.1967.03130160057009

Dates

Type	When
Created	13 years, 1 month ago (July 19, 2012, 1:52 p.m.)
Deposited	4 months, 4 weeks ago (April 4, 2025, 7:19 p.m.)
Indexed	4 months, 4 weeks ago (April 5, 2025, 12:25 a.m.)
Issued	55 years, 11 months ago (Oct. 1, 1969)
Published	55 years, 11 months ago (Oct. 1, 1969)
Published Online	13 years, 1 month ago (July 19, 2012)
Published Print	55 years, 11 months ago (Oct. 1, 1969)

Funders 0

None

BibTeX

@article{SUMMERS_1969, title={Effects of monoamine oxidase inhibitors on the hypothermia produced in cats by halothane}, volume={37}, ISSN={1476-5381}, url={http://dx.doi.org/10.1111/j.1476-5381.1969.tb10577.x}, DOI={10.1111/j.1476-5381.1969.tb10577.x}, number={2}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={SUMMERS, R. J.}, year={1969}, month=oct, pages={400–413} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        4,
        5
      ]
    ],
    "date-time": "2025-04-05T04:25:18Z",
    "timestamp": 1743827118203,
    "version": "3.40.3"
  },
  "reference-count": 33,
  "publisher": "Wiley",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2012,
            7,
            19
          ]
        ],
        "date-time": "2012-07-19T00:00:00Z",
        "timestamp": 1342656000000
      },
      "content-version": "vor",
      "delay-in-days": 15632,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [
      "bpspubs.onlinelibrary.wiley.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1969,
        10
      ]
    ]
  },
  "abstract": "<jats:p><jats:list list-type=\"explicit-label\"><jats:list-item><jats:p>. In cats, the effects of intraperitoneal injections of four monoamine oxidase (MAO) inhibitors, tranylcypromine, pheniprazine, pargyline, and nialamide, were examined on rectal temperature and on the hypothermia during anaesthesia produced by a 2 hr period of halothane inhalation.</jats:p></jats:list-item><jats:list-item><jats:p>. A 2 hr period of halothane inhalation produced a steady fall in temperature amounting to between 2\u00b0 and 3\u00b75\u00b0 C. After discontinuation of halothane inhalation, temperature quickly returned to the pre\u2010anaesthetic level but no pyrexia developed. A peculiar stiffness of the leg muscles occurred in several experiments either at the beginning of the inhalation or after its discontinuation.</jats:p></jats:list-item><jats:list-item><jats:p>. An injection of tranylcypromine (5 mg/kg) caused a rise in rectal temperature and prevented the hypothermia of halothane anaesthesia. This effect lasted for at least 4 hr; 20 hr after the injection, halothane again caused hypothermia.</jats:p></jats:list-item><jats:list-item><jats:p>. An injection of pheniprazine (10 mg/kg) usually caused a small rise in temperature which was not sustained. Pheniprazine not only prevented the hypothermia of halothane anaesthesia during the subsequent 20 hr, but during the first few hours after the injection halothane inhalation actually produced a steep rise in temperature.</jats:p></jats:list-item><jats:list-item><jats:p>. An injection of pargyline (50 mg/kg) had no effect on temperature but the hypothermia due to halothane inhalation was prevented 1 hr after the injection and attenuated after 20 hr. Injection of 200 mg/kg caused a steady rise in temperature which was accelerated when halothane was administered 1 hr later.</jats:p></jats:list-item><jats:list-item><jats:p>. An injection of nialamide (10, 25 or 50 mg/kg) had no immediate effect on temperature, but pyrexia developed overnight after the two larger doses. The effect on the hypothermia due to halothane inhalation was greater 20 hr after the injection than it was after 1 to 2 hr. Twenty hours after injection of the two larger doses, halothane no longer produced hypothermia but caused a lethal rise in temperature either during or after its inhalation.</jats:p></jats:list-item><jats:list-item><jats:p>. In rabbits, the effect on temperature of halothane inhalation varied. Either temperature rose slightly or it fell, but not as much as in cats. In one rabbit in which the inhalation had produced a transient rise, pyrexia developed 40 min after discontinuation of halothane.</jats:p></jats:list-item></jats:list></jats:p>",
  "DOI": "10.1111/j.1476-5381.1969.tb10577.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2012,
        7,
        19
      ]
    ],
    "date-time": "2012-07-19T17:52:03Z",
    "timestamp": 1342720323000
  },
  "page": "400-413",
  "update-policy": "https://doi.org/10.1002/crossmark_policy",
  "source": "Crossref",
  "is-referenced-by-count": 13,
  "title": "Effects of monoamine oxidase inhibitors on the hypothermia produced in cats by halothane",
  "prefix": "10.1111",
  "volume": "37",
  "author": [
    {
      "given": "R. J.",
      "family": "SUMMERS",
      "sequence": "first",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2012,
        7,
        19
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.1959.tb49239.x"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/bmj.2.4903.1526"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1113/jphysiol.1965.sp007801"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF03003609"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF03003611"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1113/jphysiol.1967.sp008129"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1113/jphysiol.1967.sp008264"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1113/jphysiol.1967.sp008202"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1113/jphysiol.1964.sp007454"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1113/jphysiol.1964.sp007527"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.1962.tb50123.x"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1001/jama.1964.03070180054008"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "first-page": "212",
      "DOI": "10.1016/S0022-3565(25)25687-7",
      "article-title": "Effects of several monoamine oxidase inhibitors on cardiovascular actions of naturally occurring amines in dog",
      "volume": "127",
      "author": "Goldberg L. I.",
      "year": "1959",
      "journal-title": "J. Pharmac. exp. Ther"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1476-5381.1969.tb09525.x"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/bmj.3.5618.594"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/bmj.4.5633.750"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF03003608"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/bmj.3.5621.803-d"
    },
    {
      "key": "e_1_2_1_20_1",
      "first-page": "840",
      "article-title": "Symposium on monoamine oxidase inhibitors",
      "volume": "80",
      "author": "Kinross\u2010Wright J.",
      "year": "1959",
      "journal-title": "Ann. N.Y. Acad. Sci"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF03003610"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "crossref",
      "first-page": "180",
      "DOI": "10.1016/S0022-3565(25)26090-6",
      "article-title": "Cardiac activities of several monoamine\u2010oxidase inhibitors",
      "volume": "133",
      "author": "Lee W. C.",
      "year": "1961",
      "journal-title": "J. Pharmac. exp. Ther"
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF03003718"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF03003606"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00000542-195507000-00021"
    },
    {
      "key": "e_1_2_1_26_1",
      "first-page": "1748",
      "article-title": "Variations intersp\u00e9cifiques des modifications de la temp\u00e9rature centrale li\u00e9es a l'injection c\u00e9r\u00e9bro\u2010ventriculaire de catecholamines et de 5\u2010hydroxytryptamine",
      "volume": "159",
      "author": "Ruckebusch Y.",
      "year": "1965",
      "journal-title": "C.r. S\u00e9anc. Soc. Biol"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1001/jama.1964.03070250011002"
    },
    {
      "key": "e_1_2_1_28_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.1963.tb13335.x"
    },
    {
      "key": "e_1_2_1_29_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.1963.tb13329.x"
    },
    {
      "key": "e_1_2_1_30_1",
      "first-page": "277",
      "article-title": "Observations on cardiovascular effects of tranylcypromine",
      "volume": "19",
      "author": "Spencer J. N.",
      "year": "1960",
      "journal-title": "Fedn Proc"
    },
    {
      "key": "e_1_2_1_31_1",
      "doi-asserted-by": "crossref",
      "first-page": "178",
      "DOI": "10.1001/jama.1967.03130160052008",
      "article-title": "Fulminant hyperthermia during anaesthesia and surgery",
      "volume": "202",
      "author": "Stephen C. R.",
      "year": "1967",
      "journal-title": "J. Am. med. Ass"
    },
    {
      "key": "e_1_2_1_32_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF03003607"
    },
    {
      "key": "e_1_2_1_33_1",
      "doi-asserted-by": "crossref",
      "first-page": "483",
      "DOI": "10.1016/S0031-6997(25)07427-7",
      "article-title": "Catecholamines in brain",
      "volume": "11",
      "author": "Vogt M.",
      "year": "1959",
      "journal-title": "Pharmac. Rev"
    },
    {
      "key": "e_1_2_1_34_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1001/jama.1967.03130160057009"
    }
  ],
  "container-title": "British Journal of Pharmacology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.1969.tb10577.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1969.tb10577.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2025,
        4,
        4
      ]
    ],
    "date-time": "2025-04-04T23:19:42Z",
    "timestamp": 1743808782000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.1969.tb10577.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1969,
        10
      ]
    ]
  },
  "references-count": 33,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1969,
          10
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1476-5381.1969.tb10577.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1476-5381.1969.tb10577.x",
  "relation": {},
  "ISSN": [
    "0007-1188",
    "1476-5381"
  ],
  "subject": [],
  "container-title-short": "British J Pharmacology",
  "published": {
    "date-parts": [
      [
        1969,
        10
      ]
    ]
  },
  "assertion": [
    {
      "value": "2012-07-19",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}