DOI: 10.1111/j.1475-097x.1984.tb00802.x. Insulin is the mediator of feecling‐related thermogenesis: insulin resistance and/or deficiency results in a thermogenic defect which contributes to the pathogenesis of obesity

Insulin is the mediator of feecling‐related thermogenesis: insulin resistance and/or deficiency results in a thermogenic defect which contributes to the pathogenesis of obesity

10.1111/j.1475-097x.1984.tb00802.x

Crossref journal-article

Wiley

Clinical Physiology (311)

Abstract

Summary. Obesity is characterized by insulin resistance which predisposes to the development of impaired glucose tolerance. It is postulated that in addition to its role in carbohydrate metabolism, insulin is the mediator of feecling‐related increases in thermogenesis (the thermic effect of food and dietary‐induced thermogenesis). The development of insulin resistance and/or deficiency is postulated to result in a decrease in feecling‐related, insulin‐mediated thermogenesis. As a consequence of this thermogenic defect there is an increase in efficiency of weight gain which accelerates the development and facilitates the maintenance of the obese state. Abnormalities in the insulin axis are thus not only involved in the pathogenesis of the carbohydrate intolerance of obesity but are also proposed as having a central role in a dysregulation of energy balance which contributes to the pathogenesis of obesity.

Bibliography

Felig, P. (1984). Insulin is the mediator of feeclingârelated thermogenesis: insulin resistance and/or deficiency results in a thermogenic defect which contributes to the pathogenesis of obesity. Clinical Physiology, 4(4), 267â273. Portico.

Authors 1

Philip Felig (first)

References 30 Referenced 58

10.1093/ajcn/36.3.444 / Am J clin Nutr / Refeecling after fasting in the rat. Effects on body composition and food efficiency by Björntorp P. (1982)
{'key': 'e_1_2_1_3_1', 'volume-title': 'Major Problems in Internal Medicine', 'author': 'Brayg A.', 'year': '1976'} / Major Problems in Internal Medicine by Brayg A. (1976)
10.2337/diabetes.32.11.1023
{'key': 'e_1_2_1_5_1', 'first-page': '798', 'volume-title': 'Endocrinology and Metabolism', 'author': 'Felig P.', 'year': '1981'} / Endocrinology and Metabolism by Felig P. (1981)
{'key': 'e_1_2_1_6_1', 'first-page': 'E45', 'article-title': 'Energy expenditure in obesity in fasting and postprandial state', 'volume': '244', 'author': 'Felig P.', 'year': '1983', 'journal-title': 'Am J Physiol'} / Am J Physiol / Energy expenditure in obesity in fasting and postprandial state by Felig P. (1983)
10.1172/JCI107593
{'key': 'e_1_2_1_8_1', 'first-page': '200', 'volume-title': 'Recent Advances in Obesity Research', 'author': 'Garrow J. S.', 'year': '1978'} / Recent Advances in Obesity Research by Garrow J. S. (1978)
10.1079/BJN19720084
10.2337/diacare.31.11.1023
GoldmanR. F. HaismanM. F. BynumG. HortonE. S.&SimsE. D. H.(1973)Experimental obesity in man. Metabolic rate in relation to dietary intake. In:Obesity in Perspective.(ed.BrayG. A.) pp.323–334. Dhew Publication No. (NIH) 75–708.
HortonE. S. DanforthE. JR. SimsE. A. H.&SalansL. B.(1973)Endocrine and metabolic alterations in spontaneous and experimental obesity. InObesity in Perspective. (ed.BrayG. A.) pp.323–334. Dhew Publication No. (NIH) 75–70.
10.1016/S0140-6736(83)90354-9
10.1038/279322a0
10.1136/bmj.1.6164.655
{'key': 'e_1_2_1_16_1', 'first-page': '180A', 'article-title': 'Insulin stimulated Na‐K‐ATPase activity is diminished in adipocytes from obese man', 'volume': '23', 'author': 'Klimes I.', 'year': '1982', 'journal-title': 'Diabetologia'} / Diabetologia / Insulin stimulated Na‐K‐ATPase activity is diminished in adipocytes from obese man by Klimes I. (1982)
10.1056/NEJM197806082982306
10.1079/BJN19820005
{'key': 'e_1_2_1_19_1', 'first-page': '353', 'article-title': 'Diabetes mellitus. A ‘thrifty’ genotype rendered detrimental by progress', 'volume': '14', 'author': 'Neel J. V.', 'year': '1962', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Diabetes mellitus. A ‘thrifty’ genotype rendered detrimental by progress by Neel J. V. (1962)
10.1016/0026-0495(83)90029-X
{'key': 'e_1_2_1_21_1', 'first-page': 'E15', 'article-title': 'Insulin action and resistance in obesity and noninsulin‐dependent Type II diabetes mellitus', 'volume': '243', 'author': 'Olefsky J. M.', 'year': '1982', 'journal-title': 'Am J Physiol'} / Am J Physiol / Insulin action and resistance in obesity and noninsulin‐dependent Type II diabetes mellitus by Olefsky J. M. (1982)
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10.1016/0026-0495(83)90028-8
10.1016/S0300-595X(76)80027-8
10.1016/0026-0495(81)90092-5

Dates

Type	When
Created	17 years, 4 months ago (April 7, 2008, 5:11 a.m.)
Deposited	1 year, 10 months ago (Oct. 19, 2023, 3:34 p.m.)
Indexed	1 year, 1 month ago (Aug. 4, 2024, 4 a.m.)
Issued	41 years, 1 month ago (Aug. 1, 1984)
Published	41 years, 1 month ago (Aug. 1, 1984)
Published Online	17 years, 2 months ago (June 28, 2008)
Published Print	41 years, 1 month ago (Aug. 1, 1984)

Funders 0

None

BibTeX

@article{Felig_1984, title={Insulin is the mediator of feecling‐related thermogenesis: insulin resistance and/or deficiency results in a thermogenic defect which contributes to the pathogenesis of obesity}, volume={4}, ISSN={1365-2281}, url={http://dx.doi.org/10.1111/j.1475-097x.1984.tb00802.x}, DOI={10.1111/j.1475-097x.1984.tb00802.x}, number={4}, journal={Clinical Physiology}, publisher={Wiley}, author={Felig, Philip}, year={1984}, month=aug, pages={267–273} }

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