The p53 family in nervous system development and disease
10.1111/j.1471-4159.2006.03980.x
Crossref journal-article
Wiley
Journal of Neurochemistry (311)
Abstract

AbstractThe p53 family, consisting of the tumor suppressors p53, p63 and p73, play a vital role as regulators of survival and apoptosis in the developing, adult and injured nervous system. These proteins function as key survival and apoptosis checkpoints in neurons, acting as either rheostats or sensors responsible for integrating multiple pro‐apoptotic and survival cues. A dramatic example of this checkpoint function is observed in developing sympathetic neurons, where a pro‐survival and truncated form of p73 antagonizes the apoptotic functions of p53 and p63. Thus the levels and activities of the different p53 family members may ultimately determine whether neurons either live or die during nervous system development and disease.

Bibliography

Jacobs, W. B., Kaplan, D. R., & Miller, F. D. (2006). The p53 family in nervous system development and disease. Journal of Neurochemistry, 97(6), 1571–1584. Portico.

Authors 3
  1. W. Bradley Jacobs (first)
  2. David R. Kaplan (additional)
  3. Freda D. Miller (additional)
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Dates
Type When
Created 19 years, 2 months ago (June 19, 2006, 7:43 a.m.)
Deposited 1 year, 10 months ago (Oct. 15, 2023, 12:08 p.m.)
Indexed 4 months, 1 week ago (April 17, 2025, 3:45 p.m.)
Issued 19 years, 2 months ago (June 1, 2006)
Published 19 years, 2 months ago (June 1, 2006)
Published Online 19 years, 2 months ago (June 19, 2006)
Published Print 19 years, 2 months ago (June 1, 2006)
Funders 0

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@article{Jacobs_2006, title={The p53 family in nervous system development and disease}, volume={97}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.2006.03980.x}, DOI={10.1111/j.1471-4159.2006.03980.x}, number={6}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Jacobs, W. Bradley and Kaplan, David R. and Miller, Freda D.}, year={2006}, month=jun, pages={1571–1584} }