DOI: 10.1111/j.1471-4159.2005.03635.x. Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injury‐dependent and reactivated developmental processes

Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injury‐dependent and reactivated developmental processes

10.1111/j.1471-4159.2005.03635.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

AbstractOne of the most striking features of the injured mature peripheral nervous system is the ability to regenerate. The lesioned peripheral nervous system displays stereotypic histopathological reactions indicating the activation of a co‐ordinated lesion‐induced gene expression programme. Previous research has already identified molecular components of this axonal switch from a mature transmitting to a regenerative growth mode. The observed alterations in gene expression within the lesioned distal nerve stump were largely attributed to recapitulated developmental processes. However, to our knowledge, this hypothesis has not been proven systematically. Most of the stereotypic molecular and cellular reactions during nerve development and repair can be assigned to specific time windows. Consequently, we have compared gene expression profiles of both paradigms at six different time‐points each by means of cDNA array hybridization. Our data identified injury‐specific molecular reactions and revealed to what extent developmental mechanisms are reactivated in response to nerve lesion. Ninety‐one genes (47% of the regeneration‐associated genes) were found to be significantly regulated in both paradigms, suggesting that regeneration only partially recapitulates development and that approximately half of the regulated genes are part of a regeneration‐dependent programme. Interestingly, mainly genes encoding signal transducers or factors involved in processes such as cell death, immune response, transport and transcriptional regulation showed injury‐specific gene expression.

Bibliography

Bosse, F., HasenpuschâTheil, K., KÃ¼ry, P., & MÃ¼ller, H. W. (2006). Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injuryâdependent and reactivated developmental processes. Journal of Neurochemistry, 96(5), 1441â1457. Portico.

Authors 4

Frank Bosse (first)
Kerstin Hasenpusch‐Theil (additional)
Patrick Küry (additional)
Hans Werner Müller (additional)

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Dates

Type	When
Created	19 years, 7 months ago (Jan. 30, 2006, 12:11 p.m.)
Deposited	1 year, 10 months ago (Oct. 15, 2023, 3:28 p.m.)
Indexed	1 month, 2 weeks ago (July 14, 2025, 11:33 p.m.)
Issued	19 years, 6 months ago (Feb. 8, 2006)
Published	19 years, 6 months ago (Feb. 8, 2006)
Published Online	19 years, 6 months ago (Feb. 8, 2006)
Published Print	19 years, 6 months ago (March 1, 2006)

Funders 0

None

BibTeX

@article{Bosse_2006, title={Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injury‐dependent and reactivated developmental processes}, volume={96}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.2005.03635.x}, DOI={10.1111/j.1471-4159.2005.03635.x}, number={5}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Bosse, Frank and Hasenpusch‐Theil, Kerstin and Küry, Patrick and Müller, Hans Werner}, year={2006}, month=feb, pages={1441–1457} }

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