DOI: 10.1111/j.1471-4159.2004.02455.x. Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice

10.1111/j.1471-4159.2004.02455.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

AbstractA growing body of evidence suggests a relationship between oxidative stress and β‐amyloid (Aβ) peptide accumulation, a hallmark in the pathogenesis of Alzheimer's disease (AD). However, a direct causal relationship between oxidative stress and Aβ pathology has not been established in vivo. Therefore, we crossed mice with a knockout of one allele of manganese superoxide dismutase (MnSOD), a critical antioxidant enzyme, with Tg19959 mice, which overexpress a doubly mutated human β‐amyloid precursor protein (APP). Partial deficiency of MnSOD, which is well established to cause elevated oxidative stress, significantly increased brain Aβ levels and Aβ plaque burden in Tg19959 mice. These results indicate that oxidative stress can promote the pathogenesis of AD and further support the feasibility of antioxidant approaches for AD therapy.

Bibliography

Li, F., Calingasan, N. Y., Yu, F., Mauck, W. M., Toidze, M., Almeida, C. G., Takahashi, R. H., Carlson, G. A., Flint Beal, M., Lin, M. T., & Gouras, G. K. (2004). Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. Journal of Neurochemistry, 89(5), 1308â1312. Portico.

Authors 11

Feng Li (first)
Noel Y. Calingasan (additional)
Fangmin Yu (additional)
William M. Mauck (additional)
Marine Toidze (additional)
Claudia G. Almeida (additional)
Reisuke H. Takahashi (additional)
George A. Carlson (additional)
M. Flint Beal (additional)
Michael T. Lin (additional)
Gunnar K. Gouras (additional)

References 24 Referenced 227

10.1006/exnr.2000.7525
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Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 11:46 a.m.)
Deposited	1 year, 10 months ago (Oct. 11, 2023, 4:45 p.m.)
Indexed	2 days, 23 hours ago (Sept. 3, 2025, 5:52 a.m.)
Issued	21 years, 4 months ago (April 26, 2004)
Published	21 years, 4 months ago (April 26, 2004)
Published Online	21 years, 4 months ago (April 26, 2004)
Published Print	21 years, 3 months ago (June 1, 2004)

Funders 0

None

BibTeX

@article{Li_2004, title={Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice}, volume={89}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.2004.02455.x}, DOI={10.1111/j.1471-4159.2004.02455.x}, number={5}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Li, Feng and Calingasan, Noel Y. and Yu, Fangmin and Mauck, William M. and Toidze, Marine and Almeida, Claudia G. and Takahashi, Reisuke H. and Carlson, George A. and Flint Beal, M. and Lin, Michael T. and Gouras, Gunnar K.}, year={2004}, month=apr, pages={1308–1312} }

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