DOI: 10.1111/j.1471-4159.1993.tb13611.x. Axonal Glycoproteins with Immunoglobulin‐ and Fibronectin Type III‐Related Domains in Vertebrates: Structural Features, Binding Activities, and Signal Transduction

Axonal Glycoproteins with Immunoglobulin‐ and Fibronectin Type III‐Related Domains in Vertebrates: Structural Features, Binding Activities, and Signal Transduction

10.1111/j.1471-4159.1993.tb13611.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: The L1‐ and F11‐like axonal glycoproteins, implicated in neurite outgrowth and fasciculation, are members of the Ig superfamily comprising multiple fibronectin type III‐like domains. Their Ig‐like and fibronectin type III‐related domains are likely to be composed of seven β‐strands arranged in two opposing β‐sheets of highly similar topology. Whereas the F11‐like molecules lack a transmembrane sequence and are anchored in the plasma membrane by a glycosylphosphatidylinositol, the L1 ‐like molecules comprise cytoplasmic domains with highly conserved sequence motifs. Most of the latter proteins occur in different isoforms generated by alternative pre‐mRNA splicing, which has not been documented for molecules of the F11 subgroup. L1 ‐like proteins undergo heterophils as well as homophilic interactions, whereas only the former mode of binding was observed for F11 ‐like proteins. Evidence is accumulating that these Ig superfamily molecules with fibronectin type III‐like domains are interacting in a complex manner with each other and molecules of the extracellular matrix. Investigations assigning structure to function reveal that their individual extracellular domains serve distinct binding activities. Recent studies also suggest that L1 and NCAM are implicated in the transduction of transmembrane signals.

Bibliography

BrÃ¼mmendorf, T., & Rathjen, F. G. (1993). Axonal Glycoproteins with Immunoglobulinâ and Fibronectin Type IIIâRelated Domains in Vertebrates: Structural Features, Binding Activities, and Signal Transduction. Journal of Neurochemistry, 61(4), 1207â1219. Portico.

Authors 2

Thomas Brümmendorf (first)
Fritz G. Rathjen (additional)

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Dates

Type	When
Created	18 years, 8 months ago (Dec. 15, 2006, 9:15 p.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, 10:42 p.m.)
Indexed	3 months, 1 week ago (May 22, 2025, 5:48 a.m.)
Issued	31 years, 10 months ago (Oct. 1, 1993)
Published	31 years, 10 months ago (Oct. 1, 1993)
Published Online	18 years, 8 months ago (Dec. 15, 2006)
Published Print	31 years, 10 months ago (Oct. 1, 1993)

Funders 0

None

BibTeX

@article{Br_mmendorf_1993, title={Axonal Glycoproteins with Immunoglobulin‐ and Fibronectin Type III‐Related Domains in Vertebrates: Structural Features, Binding Activities, and Signal Transduction}, volume={61}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1993.tb13611.x}, DOI={10.1111/j.1471-4159.1993.tb13611.x}, number={4}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Brümmendorf, Thomas and Rathjen, Fritz G.}, year={1993}, month=oct, pages={1207–1219} }

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