DOI: 10.1111/j.1471-4159.1992.tb11382.x. Increased Phosphorylation of a 17‐kDa Protein Kinase C Substrate (P17) in Long‐Term Potentiation

Increased Phosphorylation of a 17‐kDa Protein Kinase C Substrate (P17) in Long‐Term Potentiation

10.1111/j.1471-4159.1992.tb11382.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: Hippocampal long‐term potentiation (LTP) is a persistent increase in the efficacy of synaptic transmission, which is widely thought to be a cellular mechanism that could contribute to learning and memory. Studies on the biochemical mechanisms underlying LTP suggest the involvement of protein kinases in both LTP induction and maintenance. In this report we describe an LTP‐associated increase in the phosphorylation in vitro of a 17‐kDa protein kinase C (PKC) substrate protein, which we have termed P17, in homogenates from the CA1 region of rat hippocampal slices. This LTP‐associated increase in phosphorylation was expressed independent of significant levels of free Ca2+, as phosphorylation reactions were performed in the presence of 500 μM EGTA. The increased phosphorylation of P17 was substantially inhibited by PKC(19–36), a selective inhibitor of PKC. These data support the model that persistent PKC activation contributes to the maintenance of LTP and implicate P17 as a potential target for PKC in the CA1 region of the hippocampus.

Bibliography

Klann, E., Chen, S., & Sweatt, J. D. (1992). Increased Phosphorylation of a 17âkDa Protein Kinase C Substrate (P17) in LongâTerm Potentiation. Journal of Neurochemistry, 58(4), 1576â1579. Portico.

Authors 3

Eric Klann (first)
Shu‐Jen Chen (additional)
J. David Sweatt (additional)

References 14 Referenced 97

10.1126/science.3003904
10.1016/S0021-9258(18)94262-6 / J. Biol. Chem. / Protein kinase C substrates from bovine brain by Baudier J. (1989)
{'key': 'e_1_2_2_4_1', 'first-page': '229', 'article-title': 'Purification and characterization of a brain‐specific protein kinase C substrate, neurogranin (p17)', 'volume': '266', 'author': 'Baudier J.', 'year': '1991', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. / Purification and characterization of a brain‐specific protein kinase C substrate, neurogranin (p17) by Baudier J. (1991)
10.1016/0003-2697(76)90527-3
10.1113/jphysiol.1983.sp014478
10.1016/0006-291X(86)90433-X
10.1016/S0021-9258(18)54221-6 / J. Biol. Chem. / Persistent protein kinase activation in the maintenance phase of long‐term potentiation by Klann E. (1991)
10.1038/340554a0
10.1038/335820a0
10.1126/science.2549638
10.1523/JNEUROSCI.10-12-03782.1990
10.1016/S0163-1047(85)91426-8
10.1038/339051a0
10.1002/jnr.490260402

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 10:47 p.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 1:21 p.m.)
Indexed	1 day, 20 hours ago (Sept. 4, 2025, 10:27 a.m.)
Issued	33 years, 5 months ago (April 1, 1992)
Published	33 years, 5 months ago (April 1, 1992)
Published Online	18 years, 11 months ago (Oct. 5, 2006)
Published Print	33 years, 5 months ago (April 1, 1992)

Funders 0

None

BibTeX

@article{Klann_1992, title={Increased Phosphorylation of a 17‐kDa Protein Kinase C Substrate (P17) in Long‐Term Potentiation}, volume={58}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1992.tb11382.x}, DOI={10.1111/j.1471-4159.1992.tb11382.x}, number={4}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Klann, Eric and Chen, Shu‐Jen and Sweatt, J. David}, year={1992}, month=apr, pages={1576–1579} }

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