DOI: 10.1111/j.1471-4159.1991.tb08246.x. Kininogen and Kinin in Experimental Spinal Cord Injury

Kininogen and Kinin in Experimental Spinal Cord Injury

10.1111/j.1471-4159.1991.tb08246.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

AbstractActivation of the kallikrein‐kinin system has been implicated in the pathogenesis of vasogenic brain edema and posttraumatic vascular injury. We determined the levels of kininogen and kinin in an experimental spinal cord injury model in the rat. Kininogen content in traumatized cord segments increased in a time‐dependent manner. Western blot analysis showed that the kininogen in traumatized cord comigrates with 68K low‐molecular‐weight kininogen or T‐ kininogen. Trypsin treatment of the kininogen in traumatized cord released both bradykinin and T‐kinin, which were separated by HPLC and quantified with a kinin radioimmu‐ noassay. Endogenous kinin levels in the frozen spinal cord also increased up to 40‐fold 2 h after injury as compared with controls. The results demonstrate an increased accumulation of kininogen and its conversion to vasoactive kinins in experimental spinal cord injury.

Bibliography

Xu, J., Hsu, C. Y., Junker, H., Chao, S., Hogan, E. L., & Chao, J. (1991). Kininogen and Kinin in Experimental Spinal Cord Injury. Journal of Neurochemistry, 57(3), 975â980. Portico.

Authors 6

Jian Xu (first)
Chung Y. Hsu (additional)
Herman Junker (additional)
Steven Chao (additional)
Edward L. Hogan (additional)
Julie Chao (additional)

References 56 Referenced 34

10.2106/00004623-197153040-00006 / J. Bone Joint Surg. [Am] / The vascular and pathological changes seen in reversible spinal cord lesion by Assenmacher D. R. (1971)
{'key': 'e_1_2_2_3_1', 'first-page': '254', 'article-title': 'Pathology of experimental spinal cord trauma. II. Ultra structure of axons and myelin', 'volume': '39', 'author': 'Balentine J. D.', 'year': '1978', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Pathology of experimental spinal cord trauma. II. Ultra structure of axons and myelin by Balentine J. D. (1978)
{'key': 'e_1_2_2_4_1', 'first-page': '236', 'article-title': 'Pathology of experimental spinal cord trauma. I. The necrotic lesion as a function of vascular injury', 'volume': '39', 'author': 'Balentine J. D.', 'year': '1978', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Pathology of experimental spinal cord trauma. I. The necrotic lesion as a function of vascular injury by Balentine J. D. (1978)
{'key': 'e_1_2_2_5_1', 'first-page': '111', 'article-title': 'Molecular and anatomical correlates of spinal cord injury', 'volume': '2', 'author': 'Banik N. L.', 'year': '1985', 'journal-title': 'Cent. Nerv. Syst. Trauma'} / Cent. Nerv. Syst. Trauma / Molecular and anatomical correlates of spinal cord injury by Banik N. L. (1985)
10.1016/0014-5793(85)81297-7
10.1016/0006-291X(85)91434-2
10.3171/jns.1980.52.6.0801
10.1002/ana.410130608
10.1002/ana.410210604
10.1016/S0021-9258(17)43789-6 / J. Biol. Chem. / Identification of tissue kallikrein in brain and in the cell‐free translation product encoded by brain mRNA by Chao J. (1983)
10.1210/endo-120-2-475
10.1016/0304-4165(88)90033-5
{'key': 'e_1_2_2_14_1', 'first-page': '646', 'article-title': 'Distinct bradykinin receptors mediate stimulation of prosta‐ glandin synthesis by endothelial cells and fibroblasts', 'volume': '244', 'author': 'Conklin B. R.', 'year': '1988', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Distinct bradykinin receptors mediate stimulation of prosta‐ glandin synthesis by endothelial cells and fibroblasts by Conklin B. R. (1988)
10.1002/jnr.490200116
10.1073/pnas.82.20.7071
{'key': 'e_1_2_2_17_1', 'first-page': '677', 'article-title': 'The fine structure of endothelial surfaces in the microcirculation of experimentally injured feline spinal cords', 'volume': '11', 'author': 'Demopoulos H. B.', 'year': '1978', 'journal-title': 'Scanning Electron Micrasc.'} / Scanning Electron Micrasc. / The fine structure of endothelial surfaces in the microcirculation of experimentally injured feline spinal cords by Demopoulos H. B. (1978)
10.3171/jns.1971.35.3.0263
10.1161/01.STR.18.4.792
{'key': 'e_1_2_2_20_1', 'first-page': 'H397', 'article-title': 'Kinins induce abnormal vascular reactivity', 'volume': '255', 'author': 'Ellis E. F.', 'year': '1988', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. / Kinins induce abnormal vascular reactivity by Ellis E. F. (1988)
10.3171/jns.1989.71.3.0437
10.1001/archneur.1979.00500400051006
10.1016/0022-510X(74)90002-1
10.1007/BF00691579 / Acta Neuropathol. (Berl.) / Ultrastructural appearances of the spinal micro vasculature between twelve hours and five days after impact injury by Griffiths I. R. (1978)
10.1007/BF00689554
10.1016/0006-8993(81)90976-8
10.1016/0024-3205(86)90160-8
10.1016/0022-510X(85)90169-8
10.1212/WNL.35.7.1003
10.1016/0022-510X(86)90114-0
10.1016/0022-510X(88)90019-6
{'key': 'e_1_2_2_32_1', 'first-page': '85', 'volume-title': 'Lipid Mediators in Ischemic Brain Damage and Experimental Epilepsy', 'author': 'Hsu C. Y.', 'year': '1990'} / Lipid Mediators in Ischemic Brain Damage and Experimental Epilepsy by Hsu C. Y. (1990)
10.3171/jns.1984.61.3.0539
10.1161/01.RES.55.3.295
10.3171/jns.1984.61.1.0097
10.1161/01.RES.31.1.36
10.1097/00005072-198311000-00009
10.1016/0968-0004(86)90293-8
10.1016/0024-3205(79)90380-1
10.1007/BF01401922
10.1146/annurev.iy.06.040188.000405
10.1017/S0317167100036301
10.3171/jns.1976.45.6.0660
{'key': 'e_1_2_2_44_1', 'first-page': '721', 'article-title': 'A sensitive radioimmunoassay method for urinary kinin in man', 'volume': '91', 'author': 'Shimamoto K.', 'year': '1978', 'journal-title': 'J. Lab. dm. Med.'} / J. Lab. dm. Med. / A sensitive radioimmunoassay method for urinary kinin in man by Shimamoto K. (1978)
10.1038/jcbfm.1987.8
10.1227/00006123-198805000-00009
10.1016/0006-8993(79)90382-2
10.1007/BF00916341
10.3171/jns.1984.61.1.0087
10.3171/jns.1986.64.2.0269
10.3171/jns.1981.54.6.0802
10.1016/0014-2999(89)90174-X
10.1161/01.RES.48.1.95
10.1002/path.1711560204
10.1111/j.1471-4159.1990.tb04577.x
{'key': 'e_1_2_2_56_1', 'first-page': '463', 'volume-title': 'Central Nervous System Trauma Status Report', 'author': 'Young W.', 'year': '1985'} / Central Nervous System Trauma Status Report by Young W. (1985)
10.1089/neu.1988.5.219

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 10:02 p.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 3:54 a.m.)
Indexed	1 year, 1 month ago (July 22, 2024, 5:49 a.m.)
Issued	33 years, 11 months ago (Sept. 1, 1991)
Published	33 years, 11 months ago (Sept. 1, 1991)
Published Online	18 years, 10 months ago (Oct. 5, 2006)
Published Print	33 years, 11 months ago (Sept. 1, 1991)

Funders 0

None

BibTeX

@article{Xu_1991, title={Kininogen and Kinin in Experimental Spinal Cord Injury}, volume={57}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1991.tb08246.x}, DOI={10.1111/j.1471-4159.1991.tb08246.x}, number={3}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Xu, Jian and Hsu, Chung Y. and Junker, Herman and Chao, Steven and Hogan, Edward L. and Chao, Julie}, year={1991}, month=sep, pages={975–980} }

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