DOI: 10.1111/j.1471-4159.1991.tb06342.x. Involvement of Nerve Growth Factor and Its Receptor in the Regulation of the Cholinergic Function in Aged Rats

Involvement of Nerve Growth Factor and Its Receptor in the Regulation of the Cholinergic Function in Aged Rats

10.1111/j.1471-4159.1991.tb06342.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: The role of nerve growth factor (NGF) and its receptor (NGFR) in the regulation of cholinergic activity has been studied during the aging process. NGFRs were quantified in cortical membranes using a radioactive binding assay. NGF levels and choline acetyltransferase (ChAT) activity were determined in cortex, hippocampus, neostriatum, and septum. These assays were performed in both adult (6‐month‐old) and aged (36‐month‐old) rats. High‐and low‐affinity 125I‐NGF binding sites were present in cortex of adult and aged rats. Furthermore, we observed a decrease in number and affinity of both NGFRs in aged rats. ChAT activity in these rats was lower (⋍30%) than in adult rats in all the brainregions examined. NGF levels were not modified in cortex and hippocampus and were decreased in neostriatum (55%) and septum (35%). In conclusion, our results suggest that, during the aging process, the cholinergic impairment is related to a decrease in NGF levels in neostriatum but not in cortex and hippocampus. The reduction in level of NGF protein in septum could be due to a decrease in number of high‐affinity 125I‐NGF binding sites.

Bibliography

Alberch, J., PÃ©rezâNavarro, E., Arenas, E., & Marsa, J. (1991). Involvement of Nerve Growth Factor and Its Receptor in the Regulation of the Cholinergic Function in Aged Rats. Journal of Neurochemistry, 57(5), 1483â1487. Portico.

Authors 4

Jordi Alberch (first)
Esther Pérez‐Navarro (additional)
Ernest Arenas (additional)
Jordi Marsa (additional)

References 44 Referenced 52

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Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 10:02 p.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 5:35 p.m.)
Indexed	2 weeks, 1 day ago (Aug. 22, 2025, 12:47 a.m.)
Issued	33 years, 10 months ago (Nov. 1, 1991)
Published	33 years, 10 months ago (Nov. 1, 1991)
Published Online	18 years, 11 months ago (Oct. 5, 2006)
Published Print	33 years, 10 months ago (Nov. 1, 1991)

Funders 0

None

BibTeX

@article{Alberch_1991, title={Involvement of Nerve Growth Factor and Its Receptor in the Regulation of the Cholinergic Function in Aged Rats}, volume={57}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1991.tb06342.x}, DOI={10.1111/j.1471-4159.1991.tb06342.x}, number={5}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Alberch, Jordi and Pérez‐Navarro, Esther and Arenas, Ernest and Marsa, Jordi}, year={1991}, month=nov, pages={1483–1487} }

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