DOI: 10.1111/j.1471-4159.1990.tb13293.x. Effects of the Amnesic Agent 2‐Deoxygalactose on Incorporation of Fucose into Chick Brain Glycoproteins

Effects of the Amnesic Agent 2‐Deoxygalactose on Incorporation of Fucose into Chick Brain Glycoproteins

10.1111/j.1471-4159.1990.tb13293.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: The interaction of the amnesic agent 2‐deoxygalactose with fucose incorporation into glycoproteins in day‐old chick forebrain has been studied with the aim of identifying glycoproteins whose synthesis is modified during memory formation. 2‐Deoxygalactose inhibited total exogenous [14C]fucose incorporation into the forebrain glycoproteins by 26%. Sodium dodecyl sulphate‐polyacrylamide gradient gel analysis revealed that intracerebrally injected 2‐[3H]deoxygalatose labelled the same eight major glycoprotein bands as were identified using [14C]fucose labelling. Subsequent investigations focussed on these selected components. Subcellular fractionation showed that between 4 and 24 h after administration of the deoxy‐sugar, the incorporated radioactivity was found predominantly at the synaptic sites, some glycoproteins being more abundant in synaptic plasma membranes and others in postsynaptic densities. This distribution pattern varied according to the time after injection. The effect of passive avoidance training, using a methylan‐thranilate‐coated bead, on [14C]fucose incorporation into forebrain was to decrease fucose uptake into components of molecular mass 150–180 kilodaltons but to increase significantly labelling of glycoproteins of molecular mass 33 and 28 kilodaltons. The possible implications of these training‐induced changes are discussed.

Bibliography

Bullock, S., Potter, J., & Rose, S. P. R. (1990). Effects of the Amnesic Agent 2âDeoxygalactose on Incorporation of Fucose into Chick Brain Glycoproteins. Journal of Neurochemistry, 54(1), 135â142. Portico.

Authors 3

Sarah Bullock (first)
Jenny Potter (additional)
Steven P. R. Rose (additional)

References 37 Referenced 34

{'key': 'e_1_2_2_2_1', 'first-page': '747', 'volume-title': 'The Neurosciences, Second Study Program', 'author': 'Barondes S. H.', 'year': '1970'} / The Neurosciences, Second Study Program by Barondes S. H. (1970)
10.1016/0003-2697(76)90527-3
{'key': 'e_1_2_2_4_1', 'volume-title': 'Neurochemistry of the Aminosugars', 'author': 'Brunngraber E. G.', 'year': '1979'} / Neurochemistry of the Aminosugars by Brunngraber E. G. (1979)
10.1111/j.1432-1033.1980.tb04959.x
10.1111/j.1471-4159.1987.tb00966.x
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{'key': 'e_1_2_2_9_1', 'article-title': 'Differing effects of 2‐deoxy‐sugars on memory formation', 'author': 'Grecksch G.', 'year': '1989', 'journal-title': 'Biomed. Biochem. Acta'} / Biomed. Biochem. Acta / Differing effects of 2‐deoxy‐sugars on memory formation by Grecksch G. (1989)
10.1021/bi00578a008
{'key': 'e_1_2_2_11_1', 'volume-title': 'Membrane Glycoproteins', 'author': 'Hughes R. C.', 'year': '1976'} / Membrane Glycoproteins by Hughes R. C. (1976)
{'key': 'e_1_2_2_12_1', 'first-page': '223', 'volume-title': 'Learning and Memory Mechanisms of Information Storage in the Nervous System', 'author': 'Jork R.', 'year': '1986'} / Learning and Memory Mechanisms of Information Storage in the Nervous System by Jork R. (1986)
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10.1111/j.1462-5822.2007.00901.x
{'key': 'e_1_2_2_15_1', 'first-page': '392', 'article-title': 'The development of the chick optic tectum. I. Normal morphology and cytoarchitectonic development', 'volume': '28', 'author': 'Vail J. H.', 'year': '1971', 'journal-title': 'Brain Res.'} / Brain Res. / The development of the chick optic tectum. I. Normal morphology and cytoarchitectonic development by Vail J. H. (1971)
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10.1016/0020-711X(77)90083-0
10.1016/0306-4522(87)90048-0
McCabeN. R.(1985)Training and fucose metabolism in chick brain.Ph.D. Thesis Open University.
10.1007/BF00965883
10.1016/0006-8993(79)90448-7
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{'key': 'e_1_2_2_28_1', 'first-page': '223', 'volume-title': 'Neural Mechanisms of Conditioning', 'author': 'Rose S. P. R.', 'year': '1985'} / Neural Mechanisms of Conditioning by Rose S. P. R. (1985)
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{'key': 'e_1_2_2_31_1', 'first-page': '308', 'article-title': 'Glycoprotein synthesis is necessary for memory formation in the chick', 'volume': '22', 'author': 'Rose S. P. R.', 'year': '1987', 'journal-title': 'Neuroscience'} / Neuroscience / Glycoprotein synthesis is necessary for memory formation in the chick by Rose S. P. R. (1987)
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{'key': 'e_1_2_2_33_1', 'article-title': 'Amnestic action of 2‐deoxy‐d‐galactose is not related to alterations in the release of dopamine and noradrenaline', 'author': 'Schroder H.', 'year': '1989', 'journal-title': 'Biomed. Biochem. Acta'} / Biomed. Biochem. Acta / Amnestic action of 2‐deoxy‐d‐galactose is not related to alterations in the release of dopamine and noradrenaline by Schroder H. (1989)
10.1111/j.1432-1033.1977.tb11293.x
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10.1111/j.1471-4159.1977.tb10712.x
{'key': 'e_1_2_2_37_1', 'first-page': '53', 'article-title': 'Quantitative morphological studies of the chick brain following PAL', 'volume': '3', 'author': 'Stewart M. G.', 'year': '1984', 'journal-title': 'MEM'} / MEM / Quantitative morphological studies of the chick brain following PAL by Stewart M. G. (1984)
10.1111/j.1471-4159.1980.tb09677.x

Dates

Type	When
Created	18 years, 8 months ago (Dec. 13, 2006, 6:05 a.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 3:25 p.m.)
Indexed	1 year, 1 month ago (July 15, 2024, 7:15 p.m.)
Issued	35 years, 8 months ago (Jan. 1, 1990)
Published	35 years, 8 months ago (Jan. 1, 1990)
Published Online	18 years, 8 months ago (Dec. 12, 2006)
Published Print	35 years, 8 months ago (Jan. 1, 1990)

Funders 0

None

BibTeX

@article{Bullock_1990, title={Effects of the Amnesic Agent 2‐Deoxygalactose on Incorporation of Fucose into Chick Brain Glycoproteins}, volume={54}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1990.tb13293.x}, DOI={10.1111/j.1471-4159.1990.tb13293.x}, number={1}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Bullock, Sarah and Potter, Jenny and Rose, Steven P. R.}, year={1990}, month=jan, pages={135–142} }

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