DOI: 10.1111/j.1471-4159.1990.tb08858.x. Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

10.1111/j.1471-4159.1990.tb08858.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: The formation of thiobarbituric acid‐reactive products was measured as an index of peroxidation by oxygen free radicals in homogenates of frontal cortex and cerebellum from brains taken at autopsy and verified histologically as being Alzheimer's (n = 6) or normal (n = 6). Compared with controls, basal peroxidation is significantly higher in Alzheimer's cortex, and this difference is also evident in the presence of exogenous iron. Peroxidation in cerebellum and levels of total glutathione, RNA, and DNA in cortex and cerebellum do not differ significantly between Alzheimer's brain and controls. Iron‐induced peroxidation in cortex is reduced by the lazaroid U‐74500A, with calculated IC50 values that are significantly higher in Alzheimer's samples (10 μM) than in controls (2.5 μM). These observations suggest that cerebral cortex from Alzheimer's patients differs from controls with respect to in vitro peroxidation.

Bibliography

Subbarao, K. V., Richardson, J. S., & Ang, L. C. (1990). Autopsy Samples of Alzheimerâs Cortex Show Increased Peroxidation In Vitro. Journal of Neurochemistry, 55(1), 342â345. Portico.

Authors 3

Kala V. Subbarao (first)
J. Steven Richardson (additional)
Lee C. Ang (additional)

References 27 Referenced 356

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{'key': 'e_1_2_2_5_1', 'first-page': '423', 'article-title': 'A new 21‐aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT‐20) cells', 'volume': '244', 'author': 'Braughler J. M.', 'year': '1988', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / A new 21‐aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT‐20) cells by Braughler J. M. (1988)
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{'key': 'e_1_2_2_8_1', 'first-page': '221', 'article-title': 'Free‐radical pathology and medicine', 'volume': '23', 'author': 'Dormandy T. L.', 'year': '1989', 'journal-title': 'J. R. Coll. Physicians Lond.'} / J. R. Coll. Physicians Lond. / Free‐radical pathology and medicine by Dormandy T. L. (1989)
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{'key': 'e_1_2_2_25_1', 'first-page': 'A630', 'article-title': "Monoamine oxidase inhibitory activity of the 21‐aminosteroid iron chelator, Lazaroid (U74500A): implications for Parkinson's disease. (Abstr)", 'volume': '4', 'author': 'Youdim M. B. H.', 'year': '1990', 'journal-title': 'FASEB J.'} / FASEB J. / Monoamine oxidase inhibitory activity of the 21‐aminosteroid iron chelator, Lazaroid (U74500A): implications for Parkinson's disease. (Abstr) by Youdim M. B. H. (1990)
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:17 p.m.)
Deposited	2 years ago (Aug. 25, 2023, 3:56 p.m.)
Indexed	1 week, 6 days ago (Aug. 21, 2025, 1:34 p.m.)
Issued	35 years, 2 months ago (July 1, 1990)
Published	35 years, 2 months ago (July 1, 1990)
Published Online	18 years, 10 months ago (Oct. 5, 2006)
Published Print	35 years, 2 months ago (July 1, 1990)

Funders 0

None

BibTeX

@article{Subbarao_1990, title={Autopsy Samples of Alzheimer’s Cortex Show Increased Peroxidation In Vitro}, volume={55}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1990.tb08858.x}, DOI={10.1111/j.1471-4159.1990.tb08858.x}, number={1}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Subbarao, Kala V. and Richardson, J. Steven and Ang, Lee C.}, year={1990}, month=jul, pages={342–345} }

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