DOI: 10.1111/j.1471-4159.1989.tb11780.x. Developmental Changes in the Calcium Dependency of γ‐Aminobutyric Acid Release from Isolated Growth Cones: Correlation with Growth Cone Morphology

Developmental Changes in the Calcium Dependency of γ‐Aminobutyric Acid Release from Isolated Growth Cones: Correlation with Growth Cone Morphology

10.1111/j.1471-4159.1989.tb11780.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

AbstractWe have investigated the development of Ca2+‐dependent ‐γ‐[3H]aminobutyric acid ([3H]GABA) release in superfused growth cone fractions isolated from rats between the postnatal ages of 1 and 11 days. We have compared this release with the overall morphology of the subcellular fractions, and identified those structures taking up [3H]GABA by electron microscopical autoradiography. In fractions isolated from rats between 1 and 5 days, K+‐evoked [3H]GABA release was completely independent of extracellular Ca2+. After 5 days a Ca2+ dependency appeared, wfiich increased with age, such that by 10 days approximately 50% of the K+‐evoked release was Ca2+ dependent. Electron microscopical analysis showed that, at all ages, large numbers of GABAergic growth cones were present in the subcellular fractions. Up to postnatal day 5, the growth cones were synaptic vesicle sparse but, after this age, increasing numbers of synaptic vesicle‐containing growth cones were seen. These results suggest that during maturation of GABAergic growth cones into synapses there is, initially, a mechanism for release that is independent of extracellular Ca2+ and that the appearance of a Ca2+‐dependent [3H]GABA release from growth cones correlates with the appearance of synaptic vesicles.

Bibliography

Taylor, J., & GordonâWeeks, P. R. (1989). Developmental Changes in the Calcium Dependency of Î³âAminobutyric Acid Release from Isolated Growth Cones: Correlation with Growth Cone Morphology. Journal of Neurochemistry, 53(3), 834â843. Portico.

Authors 2

Joanne Taylor (first)
Phillip R. Gordon‐Weeks (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:22 p.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 1:07 p.m.)
Indexed	1 year, 9 months ago (Nov. 19, 2023, 8:56 a.m.)
Issued	35 years, 11 months ago (Sept. 1, 1989)
Published	35 years, 11 months ago (Sept. 1, 1989)
Published Online	18 years, 10 months ago (Oct. 5, 2006)
Published Print	35 years, 11 months ago (Sept. 1, 1989)

Funders 0

None

BibTeX

@article{Taylor_1989, title={Developmental Changes in the Calcium Dependency of γ‐Aminobutyric Acid Release from Isolated Growth Cones: Correlation with Growth Cone Morphology}, volume={53}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1989.tb11780.x}, DOI={10.1111/j.1471-4159.1989.tb11780.x}, number={3}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Taylor, Joanne and Gordon‐Weeks, Phillip R.}, year={1989}, month=sep, pages={834–843} }

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