DOI: 10.1111/j.1471-4159.1988.tb01158.x. An Immunochemical Analysis of the Distribution of a Brain‐Specific Polypeptide, PEP‐19

An Immunochemical Analysis of the Distribution of a Brain‐Specific Polypeptide, PEP‐19

10.1111/j.1471-4159.1988.tb01158.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: Immunochemical and immunohistochemical techniques were used to map the tissue distribution and cellular localization of a rat brain‐specific polypeptide, termed PEP‐19. PEP‐19 was found to be abundant in the cerebellum and olfactory bulbs but was present at much lower levels in other gross brain regions. It was undetectable in all nonneural tissues examined but was present in the cerebellum of several vertebrates, including rat, mouse, guinea pig, monkey, and human. Immunohistochemical analysis revealed that PEP‐19 was localized to the soma, axon, and dendritic processes of rat cerebellar Purkinje cells with no demonstrable immunoreactivity in nonneuronal cell types. Furthermore, mutant mice showing degeneration of Purkinje cells exhibit markedly decreased levels of PEP‐19. Because PEP‐19 appears during the final stages of maturation of Purkinje cells, it may be utilized as a probe to monitor the development of these neurons in vivo.

Bibliography

Ziai, M. R., Sangameswaran, L., Hempstead, J. L., Danho, W., & Morgan, J. I. (1988). An Immunochemical Analysis of the Distribution of a BrainâSpecific Polypeptide, PEPâ19. Journal of Neurochemistry, 51(6), 1771â1776. Portico.

Authors 5

M. R. Ziai (first)
L. Sangameswaran (additional)
J. L. Hempstead (additional)
W. Danho (additional)
J. I. Morgan (additional)

References 21 Referenced 60

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{'key': 'e_1_2_2_16_1', 'first-page': '163', 'volume-title': 'Physiological and Biochemical Aspects of Nervous Integration', 'author': 'Sidman R. L.', 'year': '1968'} / Physiological and Biochemical Aspects of Nervous Integration by Sidman R. L. (1968)
{'key': 'e_1_2_2_17_1', 'first-page': '69', 'volume-title': "Les Mutants Pathologiques chez L'Animal", 'author': 'Sidman R. L.', 'year': '1970'} / Les Mutants Pathologiques chez L'Animal by Sidman R. L. (1970)
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:36 p.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 2:37 a.m.)
Indexed	1 year, 5 months ago (March 6, 2024, 12:05 p.m.)
Issued	36 years, 9 months ago (Dec. 1, 1988)
Published	36 years, 9 months ago (Dec. 1, 1988)
Published Online	18 years, 10 months ago (Oct. 5, 2006)
Published Print	36 years, 9 months ago (Dec. 1, 1988)

Funders 0

None

BibTeX

@article{Ziai_1988, title={An Immunochemical Analysis of the Distribution of a Brain‐Specific Polypeptide, PEP‐19}, volume={51}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1988.tb01158.x}, DOI={10.1111/j.1471-4159.1988.tb01158.x}, number={6}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Ziai, M. R. and Sangameswaran, L. and Hempstead, J. L. and Danho, W. and Morgan, J. I.}, year={1988}, month=dec, pages={1771–1776} }

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