DOI: 10.1111/j.1471-4159.1988.tb01087.x. Differences Between Vascular and Plaque Core Amyloid in Alzheimer's Disease

Differences Between Vascular and Plaque Core Amyloid in Alzheimer's Disease

10.1111/j.1471-4159.1988.tb01087.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: The predominant protein of cerebrovascular and plaque core amyloid in Alzheimer's disease, Down's syndrome, hereditary hemorrhage with amyloidosis—Dutch type, sporadic cerebral amyloid angiopathy, and age‐related amyloidosis is a unique polypeptide, called β protein. The length of the plaque amyloid protein was reported to be 42–43 residues, but the complete length of the cerebral vascular amyloid is not known. To clarify this issue, amyloid fibrils from the leptomeninges of an Alzheimer's disease patient were isolated and the primary structure determined. The complete sequence of cerebrovascular β‐amyloid protein, although homologous to the plaque core amyloid protein previously reported, has 39 residues instead of 42. Amino terminal heterogeneity is present but minimal, and it is three residues shorter at the carboxy terminus. These differences are similar to those found in two cases of hereditary hemorrhage with amyloidosis—Dutch type. The differences between vascular and plaque β‐amyloid may reflect diverse processing of the β protein precursor in the vessel wall and brain parenchyma due to tissue‐specific endopeptidases.

Bibliography

Prelli, F., Castano, E., Glenner, G. G., & Frangione, B. (1988). Differences Between Vascular and Plaque Core Amyloid in Alzheimerâs Disease. Journal of Neurochemistry, 51(2), 648â651. Portico.

Authors 4

Frances Prelli (first)
Eduardo Castano (additional)
George G. Glenner (additional)
Blas Frangione (additional)

References 22 Referenced 267

10.1016/S0021-9258(17)35652-1
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{'key': 'e_1_2_2_19_1', 'first-page': '737', 'article-title': 'The degradation of serum amyloid A protein by activated polymorphonuclear leucocytes: participation of granulocytic elastase', 'volume': '46', 'author': 'Silverman S. L.', 'year': '1982', 'journal-title': 'Immunology'} / Immunology / The degradation of serum amyloid A protein by activated polymorphonuclear leucocytes: participation of granulocytic elastase by Silverman S. L. (1982)
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YuenS. HunkapillerM. W. WilsonK. J. andYuanP. M.(1986)SDS‐PAGE electroblotting.Applied Biosystem User Bulletin 25.

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:57 p.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 1:50 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 2, 2025, 12:39 a.m.)
Issued	37 years ago (Aug. 1, 1988)
Published	37 years ago (Aug. 1, 1988)
Published Online	18 years, 10 months ago (Oct. 5, 2006)
Published Print	37 years ago (Aug. 1, 1988)

Funders 0

None

BibTeX

@article{Prelli_1988, title={Differences Between Vascular and Plaque Core Amyloid in Alzheimer’s Disease}, volume={51}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1988.tb01087.x}, DOI={10.1111/j.1471-4159.1988.tb01087.x}, number={2}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Prelli, Frances and Castano, Eduardo and Glenner, George G. and Frangione, Blas}, year={1988}, month=aug, pages={648–651} }

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