DOI: 10.1111/j.1471-4159.1987.tb05593.x. Phosphorylation of Tyrosine Hydroxylase by Cyclic GMP‐Dependent Protein Kinase

Phosphorylation of Tyrosine Hydroxylase by Cyclic GMP‐Dependent Protein Kinase

10.1111/j.1471-4159.1987.tb05593.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: Tyrosine hydroxylase purified from rat pheochro‐mocytoma was phosphorylated and activated by purified cyclic GMP‐dependent protein kinase as well as by cyclic AMP‐dependent protein kinase catalytic subunit. The extent of activation was correlated with the degree of phosphate incorporated into the enzyme. Comparable stoichio‐metric ratios (0.6 mol phosphate/mol tyrosine hydroxylase subunit) were obtained at maximal concentrations of either cyclic AMP‐dependent or cyclic GMP‐dependent protein kinases. The enzymes appeared to mediate the phosphorylation of the same residue based on the observation that incorporation was not increased when both enzymes were present. The major tryptic phosphopeptide obtained from tyrosine hydroxylase phosphorylated by each protein kinase exhibited an identical retention time following HPLC. The purified phosphopeptides also exhibited identical isoelectric points. These data provide support for the notion that the protein kinases are phosphorylating the same residue of tyrosine hydroxylase.

Bibliography

Roskoski, R., Vulliet, P. R., & Glass, D. B. (1987). Phosphorylation of Tyrosine Hydroxylase by Cyclic GMPâDependent Protein Kinase. Journal of Neurochemistry, 48(3), 840â845. Portico.

Authors 3

Robert Roskoski (first)
P. Richard Vulliet (additional)
David B. Glass (additional)

References 42 Referenced 63

10.1073/pnas.81.24.7713
10.1016/S0021-9258(19)69636-5 / J. Biol. Chem. / A specific substrate from rabbit cerebellum for guanosine 3′:5′‐monophosphate‐depen‐dent protein kinase. II. Kinetic studies on its phosphorylation by guanosine 3′:5′‐monophosphate‐dependent and adenosine 3′:5′‐monophosphate‐dependent protein kinases by Aswad D. W. (1981)
10.1016/S0021-9258(17)38207-8 / J. Biol. Chem. / Phosphorylation of cardiac troponin by guanosine 3′:5′‐monophosphate‐de‐pendent protein kinase by Blumenthal D. K. (1978)
10.1016/S0021-9258(18)67410-1 / J. Biol. Chem. / Identification of four phosphorylation sites in the N‐terminal region of tyrosine hydroxylase by Campbell D. G. (1986)
10.1016/0014-5793(80)80277-8
10.1021/bi00266a011
10.1016/S0021-9258(17)40526-6 / J. Biol. Chem. / Self‐phosphorylation of cyclic guanosine 3′:5′‐monophosphate‐dependent protein kinase from bovine lung by Jonge H. R. (1977)
10.1111/j.1432-1033.1982.tb19785.x
10.1016/S0021-9258(19)85658-2 / J. Biol. Chem. / Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP‐dependent protein kinase by Feramisco J. R. (1980)
10.1016/S0021-9258(19)83577-9 / J. Biol. Chem. / Comparison of the substrate specificity of adenosine 3′:5′‐monophosphate‐ and guanosine 3′:5′‐monophosphate dependent protein kinases by Glass D. B. (1979)
10.1146/annurev.pa.20.040180.002051
10.1073/pnas.82.2.617
{'key': 'e_1_2_2_14_1', 'first-page': '246', 'article-title': "Muscarinic cholinergic receptors in rat corpus striatum and regulation of guanosine cyclic 3′,'5‐monophosphate", 'volume': '14', 'author': 'Hanley M. R.', 'year': '1978', 'journal-title': 'Mal. Pharmacol.'} / Mal. Pharmacol. / Muscarinic cholinergic receptors in rat corpus striatum and regulation of guanosine cyclic 3′,'5‐monophosphate by Hanley M. R. (1978)
10.1021/bi00264a011
10.1016/S0021-9258(17)42626-3 / J. Biol. Chem. / DAR‐PP‐32, a dopamine and adenosine 3′:5′‐monophosphate regulated neuronal phosphoprotein by Hemmings H. C. (1984)
10.1042/bj1850089
10.1073/pnas.75.10.4744
10.1016/S0021-9258(17)40137-2
10.1111/j.1471-4159.1981.tb01641.x
{'key': 'e_1_2_2_21_1', 'first-page': '1', 'article-title': 'Elucidation of the rate‐limiting steps in norepinephrine biosynthesis in the perfused guinea‐pig heart', 'volume': '148', 'author': 'Levitt M.', 'year': '1965', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Elucidation of the rate‐limiting steps in norepinephrine biosynthesis in the perfused guinea‐pig heart by Levitt M. (1965)
10.1073/pnas.74.8.3239
10.1016/S0021-9258(17)38208-X / J. Biol. Chem / Purified cyclic GMP‐dependent protein kinase catalyzes the phosphorylation of cardiac troponin inhibitory subunit (TN‐I) by Lincoln T. M. (1978)
{'key': 'e_1_2_2_24_1', 'first-page': '3', 'article-title': 'On the role of the cAMP and cGMP‐dependent protein kinases in cell function', 'volume': '4', 'author': 'Lincoln T. M.', 'year': '1978', 'journal-title': 'J. Cyclic Nucleotide Res'} / J. Cyclic Nucleotide Res / On the role of the cAMP and cGMP‐dependent protein kinases in cell function by Lincoln T. M. (1978)
{'key': 'e_1_2_2_25_1', 'first-page': '132', 'article-title': 'Characterization and biological role of the cGMP‐dependent protein kinase', 'volume': '15', 'author': 'Lincoln T. M.', 'year': '1983', 'journal-title': 'Adv. Cyclic Nucleotide Res.'} / Adv. Cyclic Nucleotide Res. / Characterization and biological role of the cGMP‐dependent protein kinase by Lincoln T. M. (1983)
10.1016/S0021-9258(19)52451-6
{'key': 'e_1_2_2_27_1', 'volume-title': 'Protein Phosphorylation in the Nervous System', 'author': 'Nestler E. J.', 'year': '1984'} / Protein Phosphorylation in the Nervous System by Nestler E. J. (1984)
10.1016/S0021-9258(17)39749-1 / J. Biol. Chem. / Phosphorylation of mammalian myosin light chain kinases by the catalytic subunit of cyclic AMP‐dependent protein kinase and by cyclic GMP‐dependent protein kinase by Nishikawa M. (1984)
10.1016/0165-3806(81)90105-X
10.1016/0076-6879(83)99034-1
{'issue': '263', 'key': 'e_1_2_2_31_1', 'article-title': 'Regulation of tyrosine hydroxylase by cyclic GMP‐dependent phosphorylation', 'volume': '17', 'author': 'Roskoski R.', 'year': '1986', 'journal-title': 'Trans. Am. Soc. Neurochem.'} / Trans. Am. Soc. Neurochem. / Regulation of tyrosine hydroxylase by cyclic GMP‐dependent phosphorylation by Roskoski R. (1986)
10.1016/S0021-9258(20)81923-1 / J. Biol. Chem / Amino acid sequence around a “hinge” region and its “autophosphorylation” site in bovine lung cGMP‐dependent protein kinase by Takio K. (1983)
10.1111/j.1471-4159.1983.tb08144.x
10.1111/j.1471-4159.1981.tb02382.x
10.1073/pnas.77.1.92
10.1016/S0021-9258(18)89798-8 / J. Biol. Chem. / Phosphorylation of tyrosine hydroxylase by calmodulin‐dependent multipro‐tein kinase by Vulliet P. R. (1984)
10.1016/0014-5793(85)80328-8
{'key': 'e_1_2_2_38_1', 'first-page': '339', 'article-title': 'Distribution of cyclic GMP‐dependent protein kinase in various rat tissues and cell lines determined by a sensitive and specific radioimmunoassay. Eur', 'volume': '118', 'author': 'Walter U.', 'year': '1981', 'journal-title': 'J. Biochem'} / J. Biochem / Distribution of cyclic GMP‐dependent protein kinase in various rat tissues and cell lines determined by a sensitive and specific radioimmunoassay. Eur by Walter U. (1981)
10.1016/S0021-9258(18)34775-6 / J. Biol. Chem. / Phosphorylation of high mobility group 14 protein by cyclic nucleotide‐depcndent protein kinases by Walton G. M. (1982)
10.1002/1097-0142(197202)29:2<327::AID-CNCR2820290210>3.0.CO;2-3
10.1016/S0021-9258(17)37944-9 / J. Biol. Chem. / Regulation of bovine adrenal tyrosine 3′‐monooxygenase by phosphorylation‐dephosphory‐lation reaction, catalyzed by adenosine 3′:5′‐monophosphate‐dependent protein kinase and phosphoprotein phosphatase by Yamauchi T. (1979)
10.1016/S0021-9258(19)69215-X / J. Biol. Chem / A new activator protein that activates tryptophan 5‐monooxygenase and tyrosine 3′‐monooxygenase in the presence of Ca2+‐calmodulin dependent protein kinase by Yamauchi T. (1981)
10.1016/S0021-9258(19)70078-7 / J. Biol. Chem. / Sites in histone H1 selectively phosphorylated by guanosine 3′:5′‐monophos‐phate‐dependent protein kinase by Zeilig C. E. (1981)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 4 p.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 8:09 a.m.)
Indexed	1 year, 3 months ago (May 13, 2024, 11:11 p.m.)
Issued	38 years, 6 months ago (March 1, 1987)
Published	38 years, 6 months ago (March 1, 1987)
Published Online	18 years, 11 months ago (Oct. 5, 2006)
Published Print	38 years, 6 months ago (March 1, 1987)

Funders 0

None

BibTeX

@article{Roskoski_1987, title={Phosphorylation of Tyrosine Hydroxylase by Cyclic GMP‐Dependent Protein Kinase}, volume={48}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1987.tb05593.x}, DOI={10.1111/j.1471-4159.1987.tb05593.x}, number={3}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Roskoski, Robert and Vulliet, P. Richard and Glass, David B.}, year={1987}, month=mar, pages={840–845} }

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