DOI: 10.1111/j.1471-4159.1986.tb13099.x. Biochemical Correlates of Myelination in Brain and Spinal Cord of Mice Heterozygous for the Jimpy Gene

Biochemical Correlates of Myelination in Brain and Spinal Cord of Mice Heterozygous for the Jimpy Gene

10.1111/j.1471-4159.1986.tb13099.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: Brain and spinal cord of female mice heterozygous for the jimpy gene were analyzed during development for activity of ceramide galactosyl transferase (CGT) and for levels of myelin basic protein (MBP). CGT activity was low at 13–14 days in brains of heterozygous jimpy females but showed normal levels by 31 –36 days, in agreement with our earlier study of this enzyme. In cord, CGT activity was normal or slightly above normal at all ages studied, from 13–14 days into adulthood. In both brain and cord, decreased levels of MBP were observed at 13 days; by 100 days, amounts of MBP approached normal levels. Proven female carriers of the jimpy gene also showed normal levels of CGT activity, MBP, and isolated myelin at 200–250 days of age in both brain and cord. These biochemical findings agree with previous morphologic measurements in cord demonstrating deficits in myelin at early ages but compensation by 100 days. Our results show that compensation occurs earlier in cord than in brain and that levels of MBP show a closer correlation than CGT activity with amounts of myelin, as measured by either morphometric analysis or direct isolation.

Bibliography

Benjamins, J. A., Studzinski, D. M., & Skoff, R. P. (1986). Biochemical Correlates of Myelination in Brain and Spinal Cord of Mice Heterozygous for the Jimpy Gene. Journal of Neurochemistry, 47(6), 1857â1863. Portico.

Authors 3

Joyce A. Benjamins (first)
Diane M. Studzinski (additional)
Robert P. Skoff (additional)

References 35 Referenced 14

{'key': 'e_1_2_2_2_1', 'first-page': '426', 'article-title': 'Expression of mosaicism in spinal cords of jimpy heterozygous females', 'volume': '10', 'author': 'Bartlett W. P.', 'year': '1984', 'journal-title': 'Soc. Neurosci. Abstr.'} / Soc. Neurosci. Abstr. / Expression of mosaicism in spinal cords of jimpy heterozygous females by Bartlett W. P. (1984)
10.1523/JNEUROSCI.06-10-02802.1986 / J. Neurosci. / Expression of the jimpy gene in the spinal cords of heterozygous female mice. I. An early myelin deficit followed by compensation by Bartlett W. P. (1986)
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{'key': 'e_1_2_2_15_1', 'first-page': '128', 'article-title': 'The expression of myelin proteins in heterozygous and hemizygous jimpy mice', 'volume': '14', 'author': 'Kerner A. L.', 'year': '1983', 'journal-title': 'Trans. Am. Soc. Neurochem.'} / Trans. Am. Soc. Neurochem. / The expression of myelin proteins in heterozygous and hemizygous jimpy mice by Kerner A. L. (1983)
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{'key': 'e_1_2_2_19_1', 'first-page': '125', 'article-title': 'Relation of onset of decerebrate rigidity to the time of myelination in the brainstems and spinal cords of young animals', 'volume': '17', 'author': 'Langworthy O. R.', 'year': '1926', 'journal-title': 'Carnegie Institute of Washington Contrib Embryol.'} / Carnegie Institute of Washington Contrib Embryol. / Relation of onset of decerebrate rigidity to the time of myelination in the brainstems and spinal cords of young animals by Langworthy O. R. (1926)
10.1016/S0021-9258(19)52451-6
{'key': 'e_1_2_2_21_1', 'first-page': '1', 'article-title': 'Some observations on myelination in the human central nervous system', 'volume': '66', 'author': 'Lucas‐Keene M. F.', 'year': '1931', 'journal-title': 'J. Anat.'} / J. Anat. / Some observations on myelination in the human central nervous system by Lucas‐Keene M. F. (1931)
10.1111/j.1469-185X.1972.tb00969.x
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10.1111/j.1471-4159.1973.tb00254.x
10.1111/j.1471-4159.1973.tb07520.x
{'key': 'e_1_2_2_26_1', 'first-page': '614', 'article-title': 'Hypomyelination and recovery of the myelin deficit in females heterozygous for the jimpy gene', 'volume': '8', 'author': 'Rosenfeld J.', 'year': '1982', 'journal-title': 'Soc. Neurosci. Abstr.'} / Soc. Neurosci. Abstr. / Hypomyelination and recovery of the myelin deficit in females heterozygous for the jimpy gene by Rosenfeld J. (1982)
10.1111/j.1471-4159.1985.tb04025.x
10.1126/science.144.3616.309
10.1016/0006-8993(81)90047-0
10.1111/j.1471-4159.1986.tb12979.x
10.1007/BF01217922
{'key': 'e_1_2_2_32_1', 'first-page': '355', 'article-title': 'Immunocytochemistry of myelin basic proteins in adult oligodendrocytes', 'volume': '7', 'author': 'Sternberger N. H.', 'year': '1985', 'journal-title': 'J. Neuroimmunol.'} / J. Neuroimmunol. / Immunocytochemistry of myelin basic proteins in adult oligodendrocytes by Sternberger N. H. (1985)
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10.1073/pnas.76.9.4350
10.1111/j.1471-4159.1983.tb13575.x
10.1097/00005072-196904000-00002

Dates

Type	When
Created	18 years, 8 months ago (Dec. 13, 2006, 6:39 a.m.)
Deposited	1 year, 10 months ago (Oct. 20, 2023, 9:59 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 1:25 a.m.)
Issued	38 years, 8 months ago (Dec. 1, 1986)
Published	38 years, 8 months ago (Dec. 1, 1986)
Published Online	18 years, 8 months ago (Dec. 12, 2006)
Published Print	38 years, 8 months ago (Dec. 1, 1986)

Funders 0

None

BibTeX

@article{Benjamins_1986, title={Biochemical Correlates of Myelination in Brain and Spinal Cord of Mice Heterozygous for the Jimpy Gene}, volume={47}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1986.tb13099.x}, DOI={10.1111/j.1471-4159.1986.tb13099.x}, number={6}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Benjamins, Joyce A. and Studzinski, Diane M. and Skoff, Robert P.}, year={1986}, month=dec, pages={1857–1863} }

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