DOI: 10.1111/j.1471-4159.1986.tb12960.x. Changes in Nicotinic and Muscarinic Cholinergic Receptors in Alzheimer‐Type Dementia

Changes in Nicotinic and Muscarinic Cholinergic Receptors in Alzheimer‐Type Dementia

10.1111/j.1471-4159.1986.tb12960.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: Nicotinic and muscarinic cholinergic receptors were studied in autopsied brains from four histologically normal controls and five histopathologically verified cases of Alzheimer‐type dementia (ATD), using ligand binding techniques. Nicotinic and muscarinic cholinergic receptors were assessed by (–)‐[3H]nicotine and [3H]quinuclidinyl benzilate ([3H]QNB), respectively. Compared with the controls, (–)‐[3H]nicotine binding sites in the ATD brain regions examined were significantly reduced in the putamen and the nucleus basalis of Meynert (NbM). [3H]QNB binding was significantly reduced in the hippocampus and NbM. These findings suggest that there are significant changes of nicotinic and muscarinic cholinergic receptors in selected regions of ATD brains.

Bibliography

Shimohama, S., Taniguchi, T., Fujiwara, M., & Kameyama, M. (1986). Changes in Nicotinic and Muscarinic Cholinergic Receptors in AlzheimerâType Dementia. Journal of Neurochemistry, 46(1), 288â293. Portico.

Authors 4

Shun Shimohama (first)
Takashi Taniguchi (additional)
Motohatsu Fujiwara (additional)
Masakuni Kameyama (additional)

References 37 Referenced 216

10.1016/0022-510X(84)90180-1
10.1111/j.1471-4159.1984.tb00913.x
10.1002/cne.902160106
10.1093/brain/99.3.459
10.1016/S0140-6736(82)90129-5
10.1016/0006-8993(81)90148-7
10.1016/S0140-6736(76)91936-X
10.1016/0006-8993(77)90758-2
10.1001/archneur.1974.00490320001001
10.1016/0022-510X(83)90196-X
10.1016/S0021-9258(17)40829-5 / J. Biol. Chem. / Cardiac muscarinic cholinergic receptors: biochemical identification and characterization by Fields J. Z. (1978)
10.1111/j.1471-4159.1975.tb11895.x
10.1111/j.1471-4159.1984.tb02817.x
10.1002/cne.901670402
10.1002/cne.902000202
10.1016/0006-8993(83)90879-X
10.1016/S0021-9258(19)52451-6
{'issue': '1', 'key': 'e_1_2_2_19_1', 'first-page': '120', 'article-title': "Loss of M2 receptors in Alzheimer's disease", 'volume': '34', 'author': 'Mash D. C.', 'year': '1984', 'journal-title': 'Neurology'} / Neurology / Loss of M2 receptors in Alzheimer's disease by Mash D. C. (1984)
10.1002/cne.902140206
10.1016/0304-3940(83)90264-1
10.1007/BF01243370
10.1001/archneurpsyc.1958.02340050003001
10.1016/S0140-6736(77)91780-9
10.1016/0006-8993(78)90562-0
10.1126/science.7433991
10.1016/0304-3940(82)90155-0
10.1111/j.1471-4159.1984.tb02818.x
10.3171/jns.1954.11.1.0064
10.1111/j.1471-4159.1985.tb04029.x
10.1093/brain/90.3.497
{'key': 'e_1_2_2_32_1', 'first-page': '674', 'article-title': 'Alterations in muscarinic cholinergic receptors after preganglionic denervation of the superior cervical ganglion in cats', 'volume': '224', 'author': 'Taniguchi T.', 'year': '1983', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Alterations in muscarinic cholinergic receptors after preganglionic denervation of the superior cervical ganglion in cats by Taniguchi T. (1983)
{'key': 'e_1_2_2_33_1', 'first-page': '768', 'article-title': "Biochemical characterization of the muscarinic cholinergic receptors in Huntington's disease", 'volume': '143', 'author': 'Waslek G. J.', 'year': '1978', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / Biochemical characterization of the muscarinic cholinergic receptors in Huntington's disease by Waslek G. J. (1978)
10.1016/S0140-6736(77)92114-6
10.1002/ana.410100203
{'issue': '1', 'key': 'e_1_2_2_36_1', 'first-page': '121', 'article-title': "Muscarinic cholinergic receptors in the amygdala in Alzheimer's disease", 'volume': '34', 'author': 'Whitehouse P. J.', 'year': '1984', 'journal-title': 'Neurology'} / Neurology / Muscarinic cholinergic receptors in the amygdala in Alzheimer's disease by Whitehouse P. J. (1984)
10.1073/pnas.71.5.1725
{'key': 'e_1_2_2_38_1', 'first-page': '861', 'article-title': 'Muscarinic cholinergic binding in the longitudinal muscle of the guinea pig ileum with 3H‐quinuclidinyl benzilate', 'volume': '10', 'author': 'Yamamura H. I.', 'year': '1974', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / Muscarinic cholinergic binding in the longitudinal muscle of the guinea pig ileum with 3H‐quinuclidinyl benzilate by Yamamura H. I. (1974)

Dates

Type	When
Created	18 years, 8 months ago (Dec. 13, 2006, 6:58 a.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 3:11 p.m.)
Indexed	2 months, 4 weeks ago (June 3, 2025, 9:28 a.m.)
Issued	39 years, 8 months ago (Jan. 1, 1986)
Published	39 years, 8 months ago (Jan. 1, 1986)
Published Online	18 years, 8 months ago (Dec. 12, 2006)
Published Print	39 years, 8 months ago (Jan. 1, 1986)

Funders 0

None

BibTeX

@article{Shimohama_1986, title={Changes in Nicotinic and Muscarinic Cholinergic Receptors in Alzheimer‐Type Dementia}, volume={46}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1986.tb12960.x}, DOI={10.1111/j.1471-4159.1986.tb12960.x}, number={1}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Shimohama, Shun and Taniguchi, Takashi and Fujiwara, Motohatsu and Kameyama, Masakuni}, year={1986}, month=jan, pages={288–293} }

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