DOI: 10.1111/j.1471-4159.1986.tb00720.x. Biochemical and Immunocytochemical Evidence for a Deficiency of Normal Interfascicular Oligodendroglia in the CNS of the Dysmyelinating Mutant (md) Rat

Biochemical and Immunocytochemical Evidence for a Deficiency of Normal Interfascicular Oligodendroglia in the CNS of the Dysmyelinating Mutant (md) Rat

10.1111/j.1471-4159.1986.tb00720.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract Carbonic anhydrase was assayed and carbonic an‐hydrase and 5′‐nucIeotidase were localized in the CNS of myelin‐deficient mutant rats and normal littermates. The carbonic anhydrase specific activities were reduced by 61% and 29% in the mutants' forebrains and cerebella, respectively, and the total carbonic anhydrase activity in the spinal cords was reduced by 35%. Immunostained cells were found in gray matter from both normal and mutant rats, but, in the mutants, there was a marked deficiency of interfascicular oligodendrocytes in the regions that are normally occupied by white matter. It is suggested that a developmental study could indicate the step(s) at which normal differentiation of interfascicular oligodendroglia is blocked in this mutant.

Bibliography

Kahn, S., Tansey, F. A., & Cammer, W. (1986). Biochemical and Immunocytochemical Evidence for a Deficiency of Normal Interfascicular Oligodendroglia in the CNS of the Dysmyelinating Mutant (md) Rat. Journal of Neurochemistry, 47(4), 1061â1065. Portico.

Authors 3

Susan Kahn (first)
Francine A. Tansey (additional)
Wendy Cammer (additional)

References 25 Referenced 12

{'key': 'e_1_2_2_2_1', 'first-page': '99', 'volume-title': 'Inserm Symposia Series, Vol. 14: Neurological Mutants Affecting Myelination', 'author': 'Barron K. D.', 'year': '1980'} / Inserm Symposia Series, Vol. 14: Neurological Mutants Affecting Myelination by Barron K. D. (1980)
10.1016/0304-3940(82)90314-7
10.1111/j.1749-6632.1984.tb12376.x
10.1016/0165-3806(81)90075-4
10.1016/0006-8993(77)90781-8
10.1016/0165-3806(85)90090-2
10.1002/jnr.490140303
10.1177/33.1.3917467
10.1016/S0022-2275(20)38104-9 / J. Lipid Res. / Lipid class analysis of the central nervous system of myelin‐deficient Wistarrats by Csiza C. K. (1982)
{'key': 'e_1_2_2_11_1', 'first-page': '215', 'article-title': 'Myelin deficiency (md). A neurologic mutant in the Wistar rat', 'volume': '95', 'author': 'Csiza C. K.', 'year': '1979', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Myelin deficiency (md). A neurologic mutant in the Wistar rat by Csiza C. K. (1979)
10.1016/0006-8993(78)90326-8
10.1007/BF01262431
10.1016/0006-8993(85)90803-0
10.1007/BF00685135
10.1177/27.12.118210
10.1111/j.1471-4159.1982.tb12588.x
{'key': 'e_1_2_2_18_1', 'first-page': '286', 'article-title': 'Glycerol 3‐phosphate dehydrogenase in the brains of myelin deficient rats', 'volume': '16', 'author': 'Hof L.', 'year': '1985', 'journal-title': 'Trans. Am. Soc. Neurochem.'} / Trans. Am. Soc. Neurochem. / Glycerol 3‐phosphate dehydrogenase in the brains of myelin deficient rats by Hof L. (1985)
10.1111/j.1471-4159.1984.tb12770.x
10.1111/j.1471-4159.1982.tb07954.x
10.1016/0006-8993(78)90672-8
10.1016/S0021-9258(19)52451-6
10.1016/0006-8993(79)90599-7
10.1111/j.1471-4159.1983.tb12661.x
{'key': 'e_1_2_2_25_1', 'first-page': '104', 'volume-title': 'Immunocvtochemistry', 'author': 'Sternberger L. A.', 'year': '1979'} / Immunocvtochemistry by Sternberger L. A. (1979)
{'key': 'e_1_2_2_26_1', 'first-page': '1', 'article-title': 'The biology of the oligodendrocyte', 'volume': '5', 'author': 'Wood P.', 'year': '1984', 'journal-title': 'Adv. Neurochem.'} / Adv. Neurochem. / The biology of the oligodendrocyte by Wood P. (1984)

Dates

Type	When
Created	15 years, 1 month ago (July 28, 2010, 7:25 a.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 6:22 p.m.)
Indexed	1 year ago (Aug. 4, 2024, 2:01 a.m.)
Issued	38 years, 11 months ago (Oct. 1, 1986)
Published	38 years, 11 months ago (Oct. 1, 1986)
Published Online	18 years, 10 months ago (Oct. 5, 2006)
Published Print	38 years, 11 months ago (Oct. 1, 1986)

Funders 0

None

BibTeX

@article{Kahn_1986, title={Biochemical and Immunocytochemical Evidence for a Deficiency of Normal Interfascicular Oligodendroglia in the CNS of the Dysmyelinating Mutant (md) Rat}, volume={47}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1986.tb00720.x}, DOI={10.1111/j.1471-4159.1986.tb00720.x}, number={4}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Kahn, Susan and Tansey, Francine A. and Cammer, Wendy}, year={1986}, month=oct, pages={1061–1065} }

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