DOI: 10.1111/j.1471-4159.1985.tb12870.x. Molecular Genetic Analysis of Myelin‐Deficient Mice: <i>Shiverer</i> Mutant Mice Show Deletion in Gene(s) Coding for Myelin Basic Protein

Molecular Genetic Analysis of Myelin‐Deficient Mice: Shiverer Mutant Mice Show Deletion in Gene(s) Coding for Myelin Basic Protein

10.1111/j.1471-4159.1985.tb12870.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: The gene expression of myelin basic proteins (MBPs) in shiverer mutant mice was investigated by the Northern and Southern hybridization techniques. In the control mice RNA molecules from the brains which were about 2,300 nucleotides in length were hybridized to cDNA of 1.8 kb encoding for a mouse MBP, but RNA from the brains of 3‐week‐old shiverer mutant mice contained no detectable amount of MBP transcripts hybridizing to this probe. Moreover the shiverer mutant mice lost several restriction fragments that hybridized to the same probe in the control mice when each of the five restriction enzymes, i.e., HindIII, PstI, PvuII, AccI, and StuI, was used. These data suggest that the shiverer mutation may correspond to the deletion of a large portion of MBP exon(s) in the gene, and this deletion causes inefficient transcription leading to the depletion of MBPs in the myelin and the dysmyelination observed in these mice.

Bibliography

Kimura, M., Inoko, H., Katsuki, M., Ando, A., Sato, T., Hirose, T., Takashima, H., Inayama, S., Okano, H., Takamatsu, K., Mikoshiba, K., Tsukada, Y., & Watanabe, I. (1985). Molecular Genetic Analysis of MyelinâDeficient Mice: Shiverer Mutant Mice Show Deletion in Gene(s) Coding for Myelin Basic Protein. Journal of Neurochemistry, 44(3), 692â696. Portico.

Authors 13

Minoru Kimura (first)
Hidetoshi Inoko (additional)
Motoya Katsuki (additional)
Asako Ando (additional)
Tadayuki Sato (additional)
Tadaaki Hirose (additional)
Hideaki Takashima (additional)
Seiichi Inayama (additional)
Hideyuki Okano (additional)
Ken Takamatsu (additional)
Katsuhiko Mikoshiba (additional)
Yasuzo Tsukada (additional)
Itaru Watanabe (additional)

References 22 Referenced 66

10.1073/pnas.69.6.1408
10.1073/pnas.74.8.3360
10.1111/j.1471-4159.1983.tb08142.x
10.1021/bi00590a018
{'key': 'e_1_2_2_6_1', 'first-page': '24', 'volume': '48', 'author': 'Biddle R.', 'year': '1973', 'journal-title': 'Mouse News Lett.'} / Mouse News Lett. by Biddle R. (1973)
10.1093/nar/3.9.2303
10.1016/0012-1606(83)90185-9
{'key': 'e_1_2_2_9_1', 'first-page': '12', 'volume': '5', 'author': 'Chernoff G.', 'year': '1974', 'journal-title': 'Mouse News Lett.'} / Mouse News Lett. by Chernoff G. (1974)
10.1042/bj1410243
10.1016/0304-3940(79)91490-3
10.1016/0006-8993(81)90269-9
10.1111/j.1471-4159.1983.tb00830.x
10.1111/j.1471-4159.1980.tb06288.x
10.1007/978-3-642-49323-2_17
10.1038/299357a0
10.1016/0304-3940(79)91489-7
10.1016/0022-2836(77)90052-3
10.1016/0092-8674(83)90536-6
10.1016/S0022-2836(75)80083-0
10.1073/pnas.77.9.5201
10.1073/pnas.76.8.3683
10.1111/j.1471-4159.1982.tb07988.x

Dates

Type	When
Created	18 years, 8 months ago (Dec. 13, 2006, 7:10 a.m.)
Deposited	1 year, 10 months ago (Oct. 20, 2023, 11:40 a.m.)
Indexed	1 year, 7 months ago (Jan. 12, 2024, 11:25 a.m.)
Issued	40 years, 5 months ago (March 1, 1985)
Published	40 years, 5 months ago (March 1, 1985)
Published Online	18 years, 8 months ago (Dec. 12, 2006)
Published Print	40 years, 5 months ago (March 1, 1985)

Funders 0

None

BibTeX

@article{Kimura_1985, title={Molecular Genetic Analysis of Myelin‐Deficient Mice: Shiverer Mutant Mice Show Deletion in Gene(s) Coding for Myelin Basic Protein}, volume={44}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1985.tb12870.x}, DOI={10.1111/j.1471-4159.1985.tb12870.x}, number={3}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Kimura, Minoru and Inoko, Hidetoshi and Katsuki, Motoya and Ando, Asako and Sato, Tadayuki and Hirose, Tadaaki and Takashima, Hideaki and Inayama, Seiichi and Okano, Hideyuki and Takamatsu, Ken and Mikoshiba, Katsuhiko and Tsukada, Yasuzo and Watanabe, Itaru}, year={1985}, month=mar, pages={692–696} }

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