DOI: 10.1111/j.1471-4159.1985.tb07236.x. Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil

Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil

10.1111/j.1471-4159.1985.tb07236.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: In vitro translation products of gerbil brain preparations, obtained from animals killed during recirculation following transient ischemia, showed increased synthesis of a 70‐kilodalton stress protein, identified by two‐dimensional gel electrophoresis. Stimulation of stress protein synthesis was evident as early as 2 h after recirculation, at which time overall translation activity remained low. Expression of the 70‐kilodalton protein reached a maximum at 8 h recirculation, when incorporation into other translation products had returned to essentially control levels. Increased incorporation into the stress protein was still detectable after 24 h recirculation. Although the functional consequences of increased expression of this stress protein remain unknown, these results suggest that the gerbil ischemia model may provide a useful experimental system in which to study the involvement of this phenomenon in processes related to postischemic cell damage and recovery.

Bibliography

Nowak, T. S. (1985). Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil. Journal of Neurochemistry, 45(5), 1635â1641. Portico.

Authors 1

Thaddeus S. Nowak (first)

References 45 Referenced 235

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10.1016/0003-2697(84)90218-5
10.1111/j.1471-4159.1985.tb05440.x
10.1002/j.1460-2075.1984.tb02264.x
10.1073/pnas.78.3.1708
10.1002/ana.410110509
{'key': 'e_1_2_2_40_1', 'volume-title': 'Heat Shock from Bacteria to Man', 'author': 'Schlesinger M. J.', 'year': '1982'} / Heat Shock from Bacteria to Man by Schlesinger M. J. (1982)
10.1016/S0021-9258(17)44133-0 / J. Biol. Chem. / The effects of glucose on protein synthesis and thermosensitivity in Chinese hamster ovary cells by Sciandra J. J. (1983)
10.1073/pnas.81.15.4843
10.1016/0092-8674(80)90559-0
10.1016/0092-8674(84)90492-6
10.1016/S0021-9258(17)43075-4
10.1016/0306-4522(80)90096-2

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:41 p.m.)
Deposited	1 year, 10 months ago (Oct. 20, 2023, 2:39 p.m.)
Indexed	1 month, 3 weeks ago (July 6, 2025, 1:44 p.m.)
Issued	39 years, 10 months ago (Nov. 1, 1985)
Published	39 years, 10 months ago (Nov. 1, 1985)
Published Online	18 years, 10 months ago (Oct. 5, 2006)
Published Print	39 years, 10 months ago (Nov. 1, 1985)

Funders 0

None

BibTeX

@article{Nowak_1985, title={Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil}, volume={45}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1985.tb07236.x}, DOI={10.1111/j.1471-4159.1985.tb07236.x}, number={5}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Nowak, Thaddeus S.}, year={1985}, month=nov, pages={1635–1641} }

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