DOI: 10.1111/j.1471-4159.1984.tb05381.x. Phospholipid‐Sensitive Ca<sup>2+</sup>‐Dependent Protein Kinase Preferentially Phosphorylates Serine‐115 of Bovine Myelin Basic Protein

Phospholipid‐Sensitive Ca2+‐Dependent Protein Kinase Preferentially Phosphorylates Serine‐115 of Bovine Myelin Basic Protein

10.1111/j.1471-4159.1984.tb05381.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: Phospholipid‐sensitive Ca2+‐dependent protein kinase (PL‐Ca‐PK) and cyclic AMP‐dependent protein kinase (A‐PK) both preferentially phosphorylated serine residues of bovine myelin basic protein (MBP). Tryptic peptide maps of MBP phosphorylated by PL‐Ca‐PK or A‐PK, however, revealed different phosphopeptides, suggesting a difference in the intramolecular substrate specificity for the two enzymes. Serine‐115 of MBP, in the sequence (‐Arg‐Phe‐Ser(115)‐Trp‐), was found to be a preferred and probably major phosphorylation site for PL‐Ca‐PK. Because serine‐115 of bovine MBP corresponds to serine‐113 of rabbit MBP, an in vivo phosphorylation site reported by Martenson et al. (1983), and PL‐Ca‐PK is present at a very high level in brain and myelin, it is suggested that the enzyme may be responsible for the in vivo phosphorylation of this and other sites in MBP.

Bibliography

Scott Turner, R., Chou, C. âH. J., Mazzei, G. J., Dembure, P., & Kuo, J. F. (1984). PhospholipidâSensitive Ca2+âDependent Protein Kinase Preferentially Phosphorylates Serineâ115 of Bovine Myelin Basic Protein. Journal of Neurochemistry, 43(5), 1257â1264. Portico.

Authors 5

R. Scott Turner (first)
C.‐H. Jen Chou (additional)
Gonzalo J. Mazzei (additional)
Philip Dembure (additional)
J. F. Kuo (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 11:45 a.m.)
Deposited	1 year, 11 months ago (Sept. 27, 2023, 1:06 p.m.)
Indexed	1 year, 2 months ago (June 24, 2024, 11:17 a.m.)
Issued	40 years, 10 months ago (Nov. 1, 1984)
Published	40 years, 10 months ago (Nov. 1, 1984)
Published Online	18 years, 10 months ago (Oct. 5, 2006)
Published Print	40 years, 10 months ago (Nov. 1, 1984)

Funders 0

None

BibTeX

@article{Scott_Turner_1984, title={Phospholipid‐Sensitive Ca2+‐Dependent Protein Kinase Preferentially Phosphorylates Serine‐115 of Bovine Myelin Basic Protein}, volume={43}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1984.tb05381.x}, DOI={10.1111/j.1471-4159.1984.tb05381.x}, number={5}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Scott Turner, R. and Chou, C.‐H. Jen and Mazzei, Gonzalo J. and Dembure, Philip and Kuo, J. F.}, year={1984}, month=nov, pages={1257–1264} }

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