DOI: 10.1111/j.1471-4159.1983.tb13599.x. Regional Energy Balance in Rat Brain After Transient Forebrain Ischemia

Regional Energy Balance in Rat Brain After Transient Forebrain Ischemia

10.1111/j.1471-4159.1983.tb13599.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: Phosphocreatine, ATP, and glucose were severely depleted, and the lactate levels were increased in the paramedian neocortex, dorsal‐lateral striatum, and CA1 zone of hippocampus of rats exposed to 30 min of forebrain ischemia. Upon recirculation of the brain, phosphocreatine, ATP, and lactate concentrations recovered to control values in the paramedian neocortex and CA1 zone of hippocampus and to near‐control values in the striatum. The phosphocreatine and ATP concentrations then fell and the lactate levels rose in the striatum after 6–24 h, and in the CA1 zone of hippocampus after 24–72 h. The initial recovery and subsequent delayed changes in the phosphocreatine, ATP, and lactate concentrations in the striatum and hippocampus coincided with the onset and progression of morphological injury in these brain regions. The results suggest that cells in these regions regain normal or near‐normal mitochondrial function and are viable, in terms of energy production, for many hours before unknown mechanisms cause irreversible neuronal injury.

Bibliography

Pulsinelli, W. A., & Duffy, T. E. (1983). Regional Energy Balance in Rat Brain After Transient Forebrain Ischemia. Journal of Neurochemistry, 40(5), 1500â1503. Portico.

Authors 2

W. A. Pulsinelli (first)
T. E. Duffy (additional)

References 18 Referenced 256

{'key': 'e_1_2_5_2_1', 'first-page': '177', 'article-title': 'Delayed metabolic changes induced by 5 min of ischemia in gerbil brain', 'volume': '13', 'author': 'Arai H.', 'year': '1982', 'journal-title': 'Trans. Am. Soc. Neurochem. Abst'} / Trans. Am. Soc. Neurochem. Abst / Delayed metabolic changes induced by 5 min of ischemia in gerbil brain by Arai H. (1982)
10.1002/ana.410010603
10.1152/ajplegacy.1972.223.5.1158 / Am. J. Physiol / Metabolism and function of dog's brain recovering from longtime ischemia by Hinzen D. H. (1972)
10.1161/01.STR.7.3.301
10.1016/0006-8993(82)90833-2
10.1111/j.1471-4159.1977.tb07709.x
10.1016/0006-8993(74)91050-6
{'key': 'e_1_2_5_9_1', 'volume-title': 'A Flexible System of Enzymatic Analysis', 'author': 'Lowry O. H.', 'year': '1972'} / A Flexible System of Enzymatic Analysis by Lowry O. H. (1972)
10.1111/j.1471-4159.1976.tb06992.x
10.1097/00005072-198205000-00058
10.1161/01.STR.10.3.267
10.1002/ana.410110509
10.1002/ana.410110510
10.1111/j.1471-4159.1973.tb07567.x
10.1161/01.STR.10.4.437
10.1001/archneur.1973.00490300070009
10.1152/ajplegacy.1974.226.4.933 / Am. J. Physiol / Influence of birth on carbohydrate and energy metabolism in rat brain by Vannucci R. C. (1974)
10.1002/ana.410030606

Dates

Type	When
Created	18 years, 8 months ago (Dec. 15, 2006, 9:20 p.m.)
Deposited	1 year, 10 months ago (Oct. 19, 2023, 11:11 a.m.)
Indexed	1 month, 2 weeks ago (July 6, 2025, 1:44 p.m.)
Issued	42 years, 3 months ago (May 1, 1983)
Published	42 years, 3 months ago (May 1, 1983)
Published Online	17 years, 1 month ago (June 28, 2008)
Published Print	42 years, 3 months ago (May 1, 1983)

Funders 0

None

BibTeX

@article{Pulsinelli_1983, title={Regional Energy Balance in Rat Brain After Transient Forebrain Ischemia}, volume={40}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1983.tb13599.x}, DOI={10.1111/j.1471-4159.1983.tb13599.x}, number={5}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Pulsinelli, W. A. and Duffy, T. E.}, year={1983}, month=may, pages={1500–1503} }

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