DOI: 10.1111/j.1471-4159.1983.tb13598.x. Increased Binding of [<sup>3</sup>H]GABA to Striatal Membranes Following Ischemia

Increased Binding of [3H]GABA to Striatal Membranes Following Ischemia

10.1111/j.1471-4159.1983.tb13598.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: Sodium‐independent binding of [3H]γ‐aminobutyric acid ([3H]GABA) to membranes prepared from ischemic‐damaged rat striatum was studied by kinetic and time‐course analysis. Three days after 40 min of ischemia, [3H]GABA binding increased fourfold over control values. Scatchard analysis of the binding showed that ischemia significantly increased the affinity (KD) and the total number of binding sites (Bmax) for the high‐affinity GABA receptor. These results support the conclusion that transient forebrain ischemia damages striatal GABAergic neurons.

Bibliography

Francis, A., & Pulsinelli, W. (1983). Increased Binding of [3H]GABA to Striatal Membranes Following Ischemia. Journal of Neurochemistry, 40(5), 1497â1499. Portico.

Authors 2

Andrew Francis (first)
William Pulsinelli (additional)

References 20 Referenced 15

10.1016/0006-8993(77)90074-9
10.1002/cne.901800208
{'key': 'e_1_2_6_4_1', 'first-page': '442', 'article-title': 'Influences of ions, enzymes, and detergents on gamma‐amino butyric acid receptor binding in synaptic membranes of rat brain', 'volume': '13', 'author': 'Enna S.', 'year': '1977', 'journal-title': 'Mol. Pharmacol'} / Mol. Pharmacol / Influences of ions, enzymes, and detergents on gamma‐amino butyric acid receptor binding in synaptic membranes of rat brain by Enna S. (1977)
10.1016/0006-8993(76)90502-3
{'key': 'e_1_2_6_6_1', 'first-page': '431', 'article-title': 'Regional neurotransmitter enzyme activity following transient cerebral ischemia', 'volume': '30', 'author': 'Francis A.', 'year': '1980', 'journal-title': 'Neurology'} / Neurology / Regional neurotransmitter enzyme activity following transient cerebral ischemia by Francis A. (1980)
{'key': 'e_1_2_6_7_1', 'first-page': '599', 'article-title': 'Selective ischemic damage to striatal GABAergic neurons', 'volume': '6', 'author': 'Francis A.', 'year': '1980', 'journal-title': 'Soc. Neurosci. Abstr'} / Soc. Neurosci. Abstr / Selective ischemic damage to striatal GABAergic neurons by Francis A. (1980)
10.1016/0006-8993(82)90250-5
10.1016/0006-8993(79)90590-0
10.1016/0304-3940(80)90046-4
10.1111/j.1471-4159.1980.tb06270.x
10.1126/science.224459
10.1016/S0021-9258(19)52451-6
10.1016/0006-8993(75)90558-2
10.1161/01.STR.10.3.267
10.1002/ana.410110509
10.1002/cne.901870203
10.1016/0006-8993(80)90132-8
10.1016/0006-8993(77)90538-8
10.1007/BF01946537
10.1038/276618a0

Dates

Type	When
Created	18 years, 8 months ago (Dec. 15, 2006, 9:20 p.m.)
Deposited	1 year, 10 months ago (Oct. 19, 2023, 11:11 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 11, 2024, 3:08 a.m.)
Issued	42 years, 4 months ago (May 1, 1983)
Published	42 years, 4 months ago (May 1, 1983)
Published Online	17 years, 2 months ago (June 28, 2008)
Published Print	42 years, 4 months ago (May 1, 1983)

Funders 0

None

BibTeX

@article{Francis_1983, title={Increased Binding of [3H]GABA to Striatal Membranes Following Ischemia}, volume={40}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1983.tb13598.x}, DOI={10.1111/j.1471-4159.1983.tb13598.x}, number={5}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Francis, Andrew and Pulsinelli, William}, year={1983}, month=may, pages={1497–1499} }

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