DOI: 10.1111/j.1471-4159.1982.tb07964.x. Inhibition of Human Brain Aldose Reductase and Hexonate Dehydrogenase by Alrestatin and Sorbinil

Inhibition of Human Brain Aldose Reductase and Hexonate Dehydrogenase by Alrestatin and Sorbinil

10.1111/j.1471-4159.1982.tb07964.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: Human brain aldose reductase and hexonate dehydrogenase are inhibited by alrestatin (AY 22,284) and sorbinil (CP 45,634). Inhibition by alrestatin is noncompetitive for both enzymes, and slightly stronger for hexonate dehydrogenase (KI values 52‐250 μM) than for aldose reductase (KI values 170‐320 μM). Sorbinil inhibits hexonate dehydrogenase far more potently than aldose reductase, KI values being 5 μM for hexonate dehydrogenase and 150 μM for aldose reductase. The inhibition of hexonate dehydrogenase by sorbinil is noncompetitive with respect to both aldehyde and NADPH substrates, and is thus kinetically similar to the inhibition by alrestatin. However, sorbinil inhibition of aldose reductase is uncompetitive with respect to glyceraldehyde and noncompetitive with NADPH as the varied substrate. Inhibition of human brain aldose reductase by these two inhibitors is much less potent than that reported for the enzyme from other sources.

Bibliography

OâBrien, M. M., Schofield, P. J., & Edwards, M. R. (1982). Inhibition of Human Brain Aldose Reductase and Hexonate Dehydrogenase by Alrestatin and Sorbinil. Journal of Neurochemistry, 39(3), 810â814. Portico.

Authors 3

Margaret M. O'Brien (first)
Philip J. Schofield (additional)
Michael R. Edwards (additional)

References 15 Referenced 41

10.1042/bj1370143
10.1042/bj0550170
10.1126/science.182.4117.1146
10.1056/NEJM197304192881609
10.1016/0026-0495(79)90059-3
10.1016/0006-2952(74)90274-3
{'key': 'e_1_2_2_8_1', 'first-page': '357', 'article-title': 'Activators and inhibitors of lens aldose reductase', 'volume': '10', 'author': 'Jedziniak J. A.', 'year': '1971', 'journal-title': 'Invest. Ophthalmol.'} / Invest. Ophthalmol. / Activators and inhibitors of lens aldose reductase by Jedziniak J. A. (1971)
{'key': 'e_1_2_2_9_1', 'first-page': '314', 'article-title': 'The sorbitol pathway in the human lens: Aldose reductase and polyol dehydrogenase', 'volume': '20', 'author': 'Jedziniak J. A.', 'year': '1981', 'journal-title': 'Invest. Ophthalmol. Vis. Sci.'} / Invest. Ophthalmol. Vis. Sci. / The sorbitol pathway in the human lens: Aldose reductase and polyol dehydrogenase by Jedziniak J. A. (1981)
10.1016/0026-0495(79)90057-X
{'key': 'e_1_2_2_11_1', 'first-page': '30a', 'article-title': 'Red cell sorbitol: A marker for polyol pathway activity. Inhibition by sorbinil in insulin‐dependent diabetics', 'volume': '30', 'author': 'Malone J. I.', 'year': '1981', 'journal-title': 'Diabetes'} / Diabetes / Red cell sorbitol: A marker for polyol pathway activity. Inhibition by sorbinil in insulin‐dependent diabetics by Malone J. I. (1981)
{'key': 'e_1_2_2_12_1', 'first-page': '204', 'article-title': 'The effects of xylose on the isolated lens', 'volume': '13', 'author': 'Obazawa H.', 'year': '1974', 'journal-title': 'Invest. Ophthalmol.'} / Invest. Ophthalmol. / The effects of xylose on the isolated lens by Obazawa H. (1974)
10.1042/bj1870021
10.1016/0026-0495(79)90056-8
10.1016/0006-2952(76)90457-3
10.1126/science.1145193

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:53 a.m.)
Deposited	1 year, 9 months ago (Nov. 4, 2023, 8:07 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 15, 2024, 11:06 p.m.)
Issued	43 years ago (Sept. 1, 1982)
Published	43 years ago (Sept. 1, 1982)
Published Online	18 years, 10 months ago (Oct. 5, 2006)
Published Print	43 years ago (Sept. 1, 1982)

Funders 0

None

BibTeX

@article{O_Brien_1982, title={Inhibition of Human Brain Aldose Reductase and Hexonate Dehydrogenase by Alrestatin and Sorbinil}, volume={39}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1982.tb07964.x}, DOI={10.1111/j.1471-4159.1982.tb07964.x}, number={3}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={O’Brien, Margaret M. and Schofield, Philip J. and Edwards, Michael R.}, year={1982}, month=sep, pages={810–814} }

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