Effect of Motor and Premotor Cortex Ablation on Concentrations of Amino Acids, Monoamines, and Acetylcholine and on the Ultrastructure in Rat Striatum. A Confirmation of Glutamate as the Specific Cortico‐Striatal Transmitter
10.1111/j.1471-4159.1982.tb05352.x
Crossref journal-article
Wiley
Journal of Neurochemistry (311)
Abstract

Abstract: At 1, 2, and 4 weeks after unilateral premotor and motor cortex ablation in rats, a significant and lasting decrease in glutamate levels in the ipsilateral versus contralateral striatum was observed. A significant corresponding fall in aspartate was seen only after 1 week. In contrast, there was a large increase in the striatal concentrations of lysine, threonine, alanine, and glutamine 1 week after the cortical ablation. This correlates with the extensive glial proliferation in the deafferented ipsilateral striatum. Four weeks after cortical ablation the GABA concentration was significantly increased. There was no decrease in other putative transmitters (dopamine, serotonin, acetyl‐choline, glycine and taurine), nor was a glutamate decrease observed in the hippocampus or in the hypothalamus, which do not receive direct premotor and motor cortical inputs. Both biochemical and morphological evidence for a minor contralateral cortico‐striatal projection was obtained. Correlating with the fall in glutamate, ultrastructural observations indicated the degeneration of two types of striatal synapses, i.e., those of the axo‐spinous type III and of the axo‐dendritic type VII. Frontal cortex ablation clearly affects, in opposite directions, the metabolism of various striatal amino acids but not that of acetylcholine and the monoamine transmitters. The results strongly support the view that glutamate is the transmitter of the cortico‐striatal fibers.

Bibliography

Hassler, R., Haug, P., Nitsch, C., Kim, J. S., & Paik, K. (1982). Effect of Motor and Premotor Cortex Ablation on Concentrations of Amino Acids, Monoamines, and Acetylcholine and on the Ultrastructure in Rat Striatum. A Confirmation of Glutamate as the Specific Cortico‐Striatal Transmitter. Journal of Neurochemistry, 38(4), 1087–1098. Portico.

Authors 5
  1. R. Hassler (first)
  2. P. Haug (additional)
  3. C. Nitsch (additional)
  4. J. S. Kim (additional)
  5. K. Paik (additional)
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Dates
Type When
Created 18 years, 11 months ago (Oct. 5, 2006, 8:27 a.m.)
Deposited 1 year, 10 months ago (Nov. 4, 2023, 5:27 a.m.)
Indexed 1 day, 17 hours ago (Sept. 4, 2025, 9:33 a.m.)
Issued 43 years, 5 months ago (April 1, 1982)
Published 43 years, 5 months ago (April 1, 1982)
Published Online 18 years, 11 months ago (Oct. 5, 2006)
Published Print 43 years, 5 months ago (April 1, 1982)
Funders 0

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@article{Hassler_1982, title={Effect of Motor and Premotor Cortex Ablation on Concentrations of Amino Acids, Monoamines, and Acetylcholine and on the Ultrastructure in Rat Striatum. A Confirmation of Glutamate as the Specific Cortico‐Striatal Transmitter}, volume={38}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1982.tb05352.x}, DOI={10.1111/j.1471-4159.1982.tb05352.x}, number={4}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Hassler, R. and Haug, P. and Nitsch, C. and Kim, J. S. and Paik, K.}, year={1982}, month=apr, pages={1087–1098} }