DOI: 10.1111/j.1471-4159.1980.tb07883.x. Hippocampal Free Amino Acids in Alzheimer's Disease

Hippocampal Free Amino Acids in Alzheimer's Disease

10.1111/j.1471-4159.1980.tb07883.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract:The free amino acid content of the hippocampus, obtained at postmortem, has been analysed in cases of Alzheimer's disease and compared with normal cases. There were no significant differences in the levels of 23 amino acids including the transmitter candidates γ‐aminobutyric, glutamic or aspartic acids. This finding is interpreted in relation to present knowledge of transmitter pathways in the region of the hippocampus. A tendency for some amino acids to be increased in the Alzheimer group reached statistical significance for arginine. This observation is consistent with increased proteolytic or peptidase activity in Alzheimer's disease.

Bibliography

Tarbit, I., Perry, E. K., Perry, R. H., Blessed, G., & Tomlinson, B. E. (1980). Hippocampal Free Amino Acids in Alzheimerâs Disease. Journal of Neurochemistry, 35(5), 1246â1249. Portico.

Authors 5

I. Tarbit (first)
E. K. Perry (additional)
R. H. Perry (additional)
G. Blessed (additional)
B. E. Tomlinson (additional)

References 28 Referenced 68

10.1111/j.1471-4159.1975.tb03835.x
10.1093/brain/96.4.849
10.1002/9780470719749.ch4
10.1111/j.1471-4159.1973.tb07524.x
10.1111/j.1471-4159.1978.tb06241.x
{'key': 'e_1_2_1_7_1', 'first-page': '31', 'article-title': 'The investigation of inherited disorders of amino acid metabolism using the Rank Hilger Chromaspek.', 'volume': '11', 'author': 'Holton J. B.', 'year': '1977', 'journal-title': 'Medical Technologist and Scientist'} / Medical Technologist and Scientist / The investigation of inherited disorders of amino acid metabolism using the Rank Hilger Chromaspek. by Holton J. B. (1977)
10.1017/S0317167100119742
{'key': 'e_1_2_1_9_1', 'first-page': '17', 'article-title': "A search for a chemical correlate of amyloid in senile plaques in Alzheimer's disease.", 'volume': '89', 'author': 'Katzman R.', 'year': '1964', 'journal-title': 'Trans. Am. Neurol. Assoc'} / Trans. Am. Neurol. Assoc / A search for a chemical correlate of amyloid in senile plaques in Alzheimer's disease. by Katzman R. (1964)
{'key': 'e_1_2_1_10_1', 'first-page': '99', 'article-title': 'Studies in presenile dementia.', 'volume': '86', 'author': 'Korey S. A.', 'year': '1961', 'journal-title': 'Trans. Am. Neurol. Assoc'} / Trans. Am. Neurol. Assoc / Studies in presenile dementia. by Korey S. A. (1961)
10.1016/0006-8993(74)90833-6
10.1007/978-1-4613-4130-7_9
{'key': 'e_1_2_1_13_1', 'first-page': '69', 'volume-title': 'Tissue Proteinases', 'author': 'McDonald J. K.', 'year': '1971'} / Tissue Proteinases by McDonald J. K. (1971)
{'key': 'e_1_2_1_14_1', 'volume-title': 'Biochemistry and the Central Nervous System.', 'author': 'McIlwain H. I.', 'year': '1971'} / Biochemistry and the Central Nervous System. by McIlwain H. I. (1971)
10.1111/j.1471-4159.1968.tb06202.x
10.1007/978-1-4684-1617-6
{'key': 'e_1_2_1_17_1', 'first-page': '135', 'volume-title': 'Biochemistry of Dementia', 'author': 'Perry E. K.', 'year': '1980'} / Biochemistry of Dementia by Perry E. K. (1980)
10.1136/bmj.2.6150.1457
10.1111/j.1471-4159.1971.tb11979.x
10.1111/j.1471-4159.1971.tb11980.x
10.1056/NEJM197302152880703
{'key': 'e_1_2_1_22_1', 'first-page': '98', 'volume-title': 'Morphological and Biochemical Correlates of Neural Activity', 'author': 'Pope A.', 'year': '1964'} / Morphological and Biochemical Correlates of Neural Activity by Pope A. (1964)
{'key': 'e_1_2_1_23_1', 'first-page': '49', 'volume-title': 'Functions of the Septohippocampal System, Ciba Foundation Sympos. 58', 'author': 'Storm‐Mathisen J.', 'year': '1977'} / Functions of the Septohippocampal System, Ciba Foundation Sympos. 58 by Storm‐Mathisen J. (1977)
10.1016/0304-3940(78)90049-6
{'key': 'e_1_2_1_25_1', 'first-page': '32', 'article-title': 'A new amino analysis system.', 'volume': '5', 'author': 'Thomas A. J.', 'year': '1974', 'journal-title': 'Medical Technologist'} / Medical Technologist / A new amino analysis system. by Thomas A. J. (1974)
10.1016/0022-510X(68)90154-8
10.1016/0022-510X(70)90063-8
10.1139/y78-055
{'key': 'e_1_2_1_29_1', 'first-page': '95', 'article-title': 'Human cerebral free amino acids in hepatic coma', 'volume': '14', 'author': 'Weiser M.', 'year': '1978', 'journal-title': 'J. Neural Transm.'} / J. Neural Transm. / Human cerebral free amino acids in hepatic coma by Weiser M. (1978)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 6:43 a.m.)
Deposited	1 year, 10 months ago (Nov. 4, 2023, 7:44 a.m.)
Indexed	1 week, 2 days ago (Aug. 27, 2025, 12:18 p.m.)
Issued	44 years, 10 months ago (Nov. 1, 1980)
Published	44 years, 10 months ago (Nov. 1, 1980)
Published Online	18 years, 11 months ago (Oct. 5, 2006)
Published Print	44 years, 10 months ago (Nov. 1, 1980)

Funders 0

None

BibTeX

@article{Tarbit_1980, title={Hippocampal Free Amino Acids in Alzheimer’s Disease}, volume={35}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1980.tb07883.x}, DOI={10.1111/j.1471-4159.1980.tb07883.x}, number={5}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Tarbit, I. and Perry, E. K. and Perry, R. H. and Blessed, G. and Tomlinson, B. E.}, year={1980}, month=nov, pages={1246–1249} }

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