DOI: 10.1111/j.1471-4159.1979.tb05173.x. KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS

KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS

10.1111/j.1471-4159.1979.tb05173.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract— The kinetics of the uptake from blood to brain of pyruvate, lactate and glucose have been determined in rats of different ages. The carotid artery single injection technique was used in animals anaesthetized with pentobarbital. The rates of influx for each substrate were determined over a range of concentrations for the different age‐groups. Data were analysed in terms of the Michaelis‐Menten equation with a component to allow for non‐saturable diffusion. Values are given for Km, Vmax and Kd. In suckling rats (15‐21 days) the Vmax values for both pyruvate and lactate were 2.0 μmol g−1 min−1. In 28‐day‐old rats the Vmax values had fallen to one‐half and in adults they were less than one‐tenth. Km, values were higher in the younger animals. The rate of glucose transport in suckling rats was half that of 28‐day‐old and adults although there was no difference with age in the Km values.The results are discussed in relation to the net flux of these substrates in and out of brain during different stages of post‐natal development.

Bibliography

Cremer, J. E., Cunningham, V. J., Pardridge, W. M., Braun, L. D., & Oldendorf, W. H. (1979). KINETICS OF BLOODâBRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS. Journal of Neurochemistry, 33(2), 439â445. Portico.

Authors 5

Jill E. Cremer (first)
Vincent J. Cunningham (additional)
William M. Pardridge (additional)
Leon D. Braun (additional)
William H. Oldendorf (additional)

References 31 Referenced 226

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10.1152/ajplegacy.1973.225.3.586 / Am. J. Physiol. / Kinetics of unidirectional glucose transport into the isolated dog brain by Betz A. L. (1973)
10.1152/ajplegacy.1975.229.4.1110 / Am. J. Physiol. / Analysis of brain uptake and loss of radiotracers after intracarotid injection by Bradbury M. W. (1975)
10.1111/j.1748-1716.1975.tb05840.x
10.1152/ajplegacy.1970.219.5.1505 / Am. J. Physiol. / Sugar transport across the blood‐brain barrier by Buschiazzo P. M. (1970)
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10.1016/0005-2736(76)90120-6
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10.1111/j.1748-1716.1976.tb00242.x
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10.1111/j.1471-4159.1978.tb10489.x
10.1152/ajplegacy.1975.229.5.1165 / Am. J. Physiol. / Induction processes in blood‐brain transfer of ketone bodies during starvation by Gjedde A. (1975)
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10.1203/00006450-197704000-00008
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10.1152/ajplegacy.1971.221.6.1629 / Am. J. Physiol. / Brain uptake of radiolabelled amino acids, amines and hexoses after arterial injection by Oldendorf W. H. (1971)
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10.1152/ajplegacy.1973.224.6.1450
10.1152/ajplegacy.1976.230.1.94
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10.1111/j.1471-4159.1977.tb07702.x
10.3109/10408447509079857
10.1111/j.1651-2227.1966.tb08806.x
10.1152/ajplegacy.1976.230.5.1269 / Am. J. Physiol. / Carbohydrate metabolism in fetal and neonatal rat brain during anoxia and recovery by Vannucci R. C. (1976)
10.1152/ajplegacy.1975.228.2.352 / Am. J. Physiol. / Rat brain regional uptake and decarboxylation of L‐DOPA following carotid injection by Wade L. A. (1975)
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10.1152/ajplegacy.1975.229.2.432 / Am. J. Physiol. / Rates of lactic acid permeation and utilization in the isolated dog brain by Zimmer R. (1975)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 5:53 a.m.)
Deposited	1 year, 10 months ago (Nov. 4, 2023, 8:30 a.m.)
Indexed	22 hours, 1 minute ago (Sept. 4, 2025, 10:04 a.m.)
Issued	46 years, 1 month ago (Aug. 1, 1979)
Published	46 years, 1 month ago (Aug. 1, 1979)
Published Online	18 years, 11 months ago (Oct. 5, 2006)
Published Print	46 years, 1 month ago (Aug. 1, 1979)

Funders 0

None

BibTeX

@article{Cremer_1979, title={KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS}, volume={33}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1979.tb05173.x}, DOI={10.1111/j.1471-4159.1979.tb05173.x}, number={2}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Cremer, Jill E. and Cunningham, Vincent J. and Pardridge, William M. and Braun, Leon D. and Oldendorf, William H.}, year={1979}, month=aug, pages={439–445} }

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