DOI: 10.1111/j.1471-4159.1977.tb03928.x. CYCLIC NUCLEOTIDE ACCUMULATION <i>IN VITRO</i> IN THE CEREBELLUM OF ‘NERVOUS’ NEUROLOGICALLY MUTANT MICE

CYCLIC NUCLEOTIDE ACCUMULATION IN VITRO IN THE CEREBELLUM OF ‘NERVOUS’ NEUROLOGICALLY MUTANT MICE

10.1111/j.1471-4159.1977.tb03928.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract— Slices of cerebellum from Purkinje cell‐deficient, neurologically mutant ‘nervous’ mice or normal littermates synthesized cyclic AMP and cyclic GMP during in vitro incubations. Resting levels of cyclic AMP were the same in the two groups, but accumulations in the presence of kainic acid, a glutamic acid analogue, or norepinephrine were significantly greater in the ‘nervous’ mice. Resting levels of cyclic GMP were lower in the ‘nervous’ mice, but the elevations produced by kainic acid were the same in both groups. Adenylate and guanylate cyclase activities in the cerebellum were not affected by the mutation. These findings indicate that cyclic nucleotide synthesis in the cerebellum does not occur solely in the Purkinje cell population.

Bibliography

Schmidt, M. J., & Nadi, N. S. (1977). CYCLIC NUCLEOTIDE ACCUMULATION IN VITRO IN THE CEREBELLUM OF âNERVOUSâ NEUROLOGICALLY MUTANT MICE. Journal of Neurochemistry, 29(1), 87â90. Portico.

Authors 2

M. J. Schmidt (first)
N. S. Nadi (additional)

References 32 Referenced 68

{'key': 'e_1_2_2_2_1', 'first-page': '1', 'volume': '1', 'author': 'Battienberg E. L. F.', 'year': '1975', 'journal-title': 'Psychopharmac. Commun.'} / Psychopharmac. Commun. by Battienberg E. L. F. (1975)
10.1016/0006-8993(76)90233-X
10.1126/science.177.4047.436
10.1007/BF00239741
10.1016/S0021-9258(19)42363-6
CostaE. BiggioG.&GuidottiA.(1976)Tenth Congress Collegium Internationale Neuro‐Psychopharmacologicum (C.J.N.P.) Quebec Canada. 66.
10.1007/978-3-662-13147-3
10.1007/BF00768675
10.1111/j.1471-4159.1974.tb06890.x
10.1016/0006-8993(75)90800-8
10.1073/pnas.67.1.305
10.1073/pnas.68.9.2165
{'key': 'e_1_2_2_14_1', 'first-page': '135', 'volume-title': 'Methods in Enzymology', 'author': 'Johnson R. A.', 'year': '1974'} / Methods in Enzymology by Johnson R. A. (1974)
{'key': 'e_1_2_2_15_1', 'first-page': '155', 'volume-title': 'Advances in Biochemical Psychopharmacology', 'author': 'Krishna G.', 'year': '1970'} / Advances in Biochemical Psychopharmacology by Krishna G. (1970)
10.1007/BF00236557
10.1016/S0021-9258(19)52451-6
10.1016/0003-2697(74)90009-8
10.1016/0006-8993(74)90449-1
{'key': 'e_1_2_2_20_1', 'first-page': '736', 'volume': '10', 'author': 'Mao C. C.', 'year': '1974', 'journal-title': 'Molec. Pharmac.'} / Molec. Pharmac. by Mao C. C. (1974)
10.1016/0006-8993(75)90846-X
10.1016/0006-8993(75)90316-9
10.1111/j.1471-4159.1976.tb06466.x
10.1038/261420a0
{'key': 'e_1_2_2_25_1', 'first-page': '583', 'volume': '35', 'author': 'Rubin E. H.', 'year': '1976', 'journal-title': 'Fedn. Proc. Fedn Am. Socs exp Biol.'} / Fedn. Proc. Fedn Am. Socs exp Biol. by Rubin E. H. (1976)
10.1126/science.173.4002.1142
10.1016/0006-8993(76)90338-3
10.1016/0006-8993(77)90450-4
{'key': 'e_1_2_2_29_1', 'first-page': '69', 'volume-title': "Les Mutants Pathologiques chez l'Animal", 'author': 'Sidman R. L.', 'year': '1970'} / Les Mutants Pathologiques chez l'Animal by Sidman R. L. (1970)
10.1126/science.179.4073.585
{'key': 'e_1_2_2_31_1', 'first-page': '280', 'volume': '197', 'author': 'Skolnick P.', 'year': '1976', 'journal-title': 'J. Pharmac. exp. Ther.'} / J. Pharmac. exp. Ther. by Skolnick P. (1976)
10.1016/S0021-9258(19)45623-8 / J. biol. Chem. by Steiner A. L. (1972)
10.1016/S0021-9258(18)62207-0

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:26 a.m.)
Deposited	1 year, 9 months ago (Nov. 4, 2023, 12:41 p.m.)
Indexed	2 months, 2 weeks ago (June 21, 2025, 2:02 a.m.)
Issued	48 years, 2 months ago (July 1, 1977)
Published	48 years, 2 months ago (July 1, 1977)
Published Online	18 years, 11 months ago (Oct. 4, 2006)
Published Print	48 years, 2 months ago (July 1, 1977)

Funders 0

None

BibTeX

@article{Schmidt_1977, title={CYCLIC NUCLEOTIDE ACCUMULATION IN VITRO IN THE CEREBELLUM OF ‘NERVOUS’ NEUROLOGICALLY MUTANT MICE}, volume={29}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1977.tb03928.x}, DOI={10.1111/j.1471-4159.1977.tb03928.x}, number={1}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Schmidt, M. J. and Nadi, N. S.}, year={1977}, month=jul, pages={87–90} }

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