DOI: 10.1111/j.1471-4159.1974.tb06890.x. ELEVATION OF CYCLIC GMP LEVELS IN CENTRAL NERVOUS SYSTEM BY EXCITATORY AND INHIBITORY AMINO ACIDS<sup>1</sup>

ELEVATION OF CYCLIC GMP LEVELS IN CENTRAL NERVOUS SYSTEM BY EXCITATORY AND INHIBITORY AMINO ACIDS1

10.1111/j.1471-4159.1974.tb06890.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract—Guanosine 3′,5’cyclic monophosphate (cyclic GMP) levels in incubated slices of mouse cerebellum are increased 10‐fold by glutamate and two‐to three‐fold by glycine or γ‐aminobutyric acid (GABA). Glutamate also produces a 10‐fold increase in adenosine 3′,5’cyclic monophosphate (cyclic AMP) in the same tissue. However, GABA decreases cyclic AMP levels 30‐40 per cent, and glycine produces only a transient 50 per cent accumulation of this cyclic nucleotide. Theophylline slightly augments the accumulation of cyclic GMP produced by all three amino acids but markedly attenuates the accumulation of cyclic AMP produced by glutamate. In the absence of Ca2+, none of the three amino acids has any effect on cyclic GMP levels, and glutamate produces only a 50 per cent rise in cyclic AMP levels. The decrease of cyclic AMP levels produced by GABA is not affected by theophylline or by the absence of Ca2+. These data suggest an involvement of both cyclic GMP and cyclic AMP in the neurochemical actions of glutamate, GABA and glycine.

Bibliography

Ferrendelli, J. A., Chang, M. M., & Kinscherf, D. A. (1974). ELEVATION OF CYCLIC GMP LEVELS IN CENTRAL NERVOUS SYSTEM BY EXCITATORY AND INHIBITORY AMINO ACIDS1. Journal of Neurochemistry, 22(4), 535â540. Portico.

Authors 3

J. A. Ferrendelli (first)
M. M. Chang (additional)
D. A. Kinscherf (additional)

References 14 Referenced 233

10.1016/0006-291X(70)90193-2
10.1016/0006-291X(72)90767-X
{'key': 'e_1_2_1_4_1', 'first-page': '445', 'volume': '9', 'author': 'Ferrendelli J. A.', 'year': '1973', 'journal-title': 'Mol. Pharmacol'} / Mol. Pharmacol by Ferrendelli J. A. (1973)
10.1073/pnas.66.2.398
10.1073/pnas.69.10.3024
{'key': 'e_1_2_1_7_1', 'first-page': '367', 'volume': '4', 'author': 'Kakiuchi S.', 'year': '1968', 'journal-title': 'Mol. Pharmacol'} / Mol. Pharmacol by Kakiuchi S. (1968)
10.1016/S0021-9258(19)45752-9
10.1073/pnas.69.11.3287
10.1016/S0021-9258(19)52451-6
{'key': 'e_1_2_1_11_1', 'first-page': '222', 'volume-title': 'The Pharmacology of Synapses', 'author': 'Phillis J. W.', 'year': '1970'} / The Pharmacology of Synapses by Phillis J. W. (1970)
{'key': 'e_1_2_1_12_1', 'first-page': '773', 'volume': '32', 'author': 'Schultz G.', 'year': '1973', 'journal-title': 'Fed. Proc'} / Fed. Proc by Schultz G. (1973)
10.1073/pnas.65.4.1033
10.1016/0014-2999(72)90165-3
10.1016/S0021-9258(19)45621-4

Dates

Type	When
Created	18 years, 10 months ago (Oct. 4, 2006, 11:57 p.m.)
Deposited	1 year, 9 months ago (Nov. 4, 2023, 11:38 a.m.)
Indexed	2 months, 1 week ago (June 21, 2025, 2:02 a.m.)
Issued	51 years, 5 months ago (April 1, 1974)
Published	51 years, 5 months ago (April 1, 1974)
Published Online	18 years, 10 months ago (Oct. 4, 2006)
Published Print	51 years, 5 months ago (April 1, 1974)

Funders 0

None

BibTeX

@article{Ferrendelli_1974, title={ELEVATION OF CYCLIC GMP LEVELS IN CENTRAL NERVOUS SYSTEM BY EXCITATORY AND INHIBITORY AMINO ACIDS1}, volume={22}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1974.tb06890.x}, DOI={10.1111/j.1471-4159.1974.tb06890.x}, number={4}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Ferrendelli, J. A. and Chang, M. M. and Kinscherf, D. A.}, year={1974}, month=apr, pages={535–540} }

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