DOI: 10.1111/j.1471-4159.1973.tb05995.x. DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMES

DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMES

10.1111/j.1471-4159.1973.tb05995.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract—Potassium causes increased metabolism and release of physiologically active amino acids from suspensions of mammalian synaptosomes. Sheep and rat hypothalamic synaptosomes, and rabbit, sheep and rat cortical synaptosomes show respiratory and glycolytic response to electrical stimulation and show a parallel calcium‐dependent differential release of physiologically active amino acids. Attempts were made to eliminate the actions of heating and electrode products as the agents causing the observed effects and the case is made that depolarization is the trigger mechanism.

Bibliography

Bradford, H. F., Bennett, G. W., & Thomas, A. J. (1973). DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMES. Journal of Neurochemistry, 21(3), 495â505. Portico.

Authors 3

H. F. Bradford (first)
G. W. Bennett (additional)
A. J. Thomas (additional)

References 17 Referenced 123

Bennett G. W.andEdwardson J. A.(1973)J. Endocr. in press.
{'key': 'e_1_2_2_3_1', 'volume-title': 'Methods of Enzymatic Analysis', 'author': 'Bergmeyer H. U.', 'year': '1965'} / Methods of Enzymatic Analysis by Bergmeyer H. U. (1965)
10.1073/pnas.66.3.664
10.1111/j.1471-4159.1969.tb06444.x
10.1016/0006-8993(70)90437-3
{'key': 'e_1_2_2_7_1', 'first-page': '309', 'volume-title': 'Drugs and Cholinergic Mechanisms in the Central Nervous System', 'author': 'Bradford H. F', 'year': '1970'} / Drugs and Cholinergic Mechanisms in the Central Nervous System by Bradford H. F (1970)
{'key': 'e_1_2_2_8_1', 'first-page': '1', 'volume-title': 'Cellular Organelles and Membranes in Mental Retardation', 'author': 'Bradford H. F.', 'year': '1971'} / Cellular Organelles and Membranes in Mental Retardation by Bradford H. F. (1971)
10.1111/j.1471-4159.1969.tb09904.x
10.1111/j.1471-4159.1972.tb01376.x
10.1111/j.1471-4159.1972.tb06229.x
10.1042/bj1251027 / Biochem. J by Dodd P. R. (1971)
10.1038/240554a0
{'key': 'e_1_2_2_14_1', 'first-page': '79', 'volume': '96', 'author': 'Gray E. G.', 'year': '1962', 'journal-title': 'J. Anat'} / J. Anat by Gray E. G. (1962)
{'key': 'e_1_2_2_15_1', 'volume-title': 'Methods of Enzymatic Analysis', 'author': 'Hohorst H. U.', 'year': '1965'} / Methods of Enzymatic Analysis by Hohorst H. U. (1965)
10.1042/bj1160469
10.1111/j.1471-4159.1973.tb04260.x
10.1073/pnas.68.6.1102

Dates

Type	When
Created	18 years, 10 months ago (Oct. 4, 2006, 11:43 p.m.)
Deposited	1 year, 9 months ago (Nov. 4, 2023, 7:40 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 15, 2024, 1:07 p.m.)
Issued	52 years ago (Sept. 1, 1973)
Published	52 years ago (Sept. 1, 1973)
Published Online	18 years, 10 months ago (Oct. 4, 2006)
Published Print	52 years ago (Sept. 1, 1973)

Funders 0

None

BibTeX

@article{Bradford_1973, title={DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMES}, volume={21}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1973.tb05995.x}, DOI={10.1111/j.1471-4159.1973.tb05995.x}, number={3}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Bradford, H. F. and Bennett, G. W. and Thomas, A. J.}, year={1973}, month=sep, pages={495–505} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        9,
        15
      ]
    ],
    "date-time": "2024-09-15T17:07:54Z",
    "timestamp": 1726420074510
  },
  "reference-count": 17,
  "publisher": "Wiley",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2006,
            10,
            4
          ]
        ],
        "date-time": "2006-10-04T00:00:00Z",
        "timestamp": 1159920000000
      },
      "content-version": "vor",
      "delay-in-days": 12086,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1973,
        9
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>\u2014Potassium causes increased metabolism and release of physiologically active amino acids from suspensions of mammalian synaptosomes. Sheep and rat hypothalamic synaptosomes, and rabbit, sheep and rat cortical synaptosomes show respiratory and glycolytic response to electrical stimulation and show a parallel calcium\u2010dependent differential release of physiologically active amino acids. Attempts were made to eliminate the actions of heating and electrode products as the agents causing the observed effects and the case is made that depolarization is the trigger mechanism.</jats:p>",
  "DOI": "10.1111/j.1471-4159.1973.tb05995.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T03:43:25Z",
    "timestamp": 1160019805000
  },
  "page": "495-505",
  "source": "Crossref",
  "is-referenced-by-count": 123,
  "title": "DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMES",
  "prefix": "10.1111",
  "volume": "21",
  "author": [
    {
      "given": "H. F.",
      "family": "Bradford",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "G. W.",
      "family": "Bennett",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A. J.",
      "family": "Thomas",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2006,
        10,
        4
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_2_2_1",
      "unstructured": "Bennett G. W.andEdwardson J. A.(1973)J. Endocr. in press."
    },
    {
      "key": "e_1_2_2_3_1",
      "volume-title": "Methods of Enzymatic Analysis",
      "author": "Bergmeyer H. U.",
      "year": "1965"
    },
    {
      "key": "e_1_2_2_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.66.3.664"
    },
    {
      "key": "e_1_2_2_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1969.tb06444.x"
    },
    {
      "key": "e_1_2_2_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-8993(70)90437-3"
    },
    {
      "key": "e_1_2_2_7_1",
      "first-page": "309",
      "volume-title": "Drugs and Cholinergic Mechanisms in the Central Nervous System",
      "author": "Bradford H. F",
      "year": "1970"
    },
    {
      "key": "e_1_2_2_8_1",
      "first-page": "1",
      "volume-title": "Cellular Organelles and Membranes in Mental Retardation",
      "author": "Bradford H. F.",
      "year": "1971"
    },
    {
      "key": "e_1_2_2_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1969.tb09904.x"
    },
    {
      "key": "e_1_2_2_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1972.tb01376.x"
    },
    {
      "key": "e_1_2_2_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1972.tb06229.x"
    },
    {
      "key": "e_1_2_2_12_1",
      "doi-asserted-by": "crossref",
      "first-page": "1027",
      "DOI": "10.1042/bj1251027",
      "volume": "125",
      "author": "Dodd P. R.",
      "year": "1971",
      "journal-title": "Biochem. J"
    },
    {
      "key": "e_1_2_2_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/240554a0"
    },
    {
      "key": "e_1_2_2_14_1",
      "first-page": "79",
      "volume": "96",
      "author": "Gray E. G.",
      "year": "1962",
      "journal-title": "J. Anat"
    },
    {
      "key": "e_1_2_2_15_1",
      "volume-title": "Methods of Enzymatic Analysis",
      "author": "Hohorst H. U.",
      "year": "1965"
    },
    {
      "key": "e_1_2_2_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj1160469"
    },
    {
      "key": "e_1_2_2_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1973.tb04260.x"
    },
    {
      "key": "e_1_2_2_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.68.6.1102"
    }
  ],
  "container-title": "Journal of Neurochemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-4159.1973.tb05995.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.1973.tb05995.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        11,
        4
      ]
    ],
    "date-time": "2023-11-04T11:40:52Z",
    "timestamp": 1699098052000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1973.tb05995.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1973,
        9
      ]
    ]
  },
  "references-count": 17,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          1973,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1471-4159.1973.tb05995.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1471-4159.1973.tb05995.x",
  "relation": {},
  "ISSN": [
    "0022-3042",
    "1471-4159"
  ],
  "subject": [],
  "container-title-short": "Journal of Neurochemistry",
  "published": {
    "date-parts": [
      [
        1973,
        9
      ]
    ]
  }
}