DOI: 10.1111/j.1471-4159.1972.tb01310.x. THE EFFECT OF HYPERCAPNIC ACIDOSIS UPON SOME GLYCOLYTIC AND KREBS CYCLE‐ASSOCIATED INTERMEDIATES IN THE RAT BRAIN

THE EFFECT OF HYPERCAPNIC ACIDOSIS UPON SOME GLYCOLYTIC AND KREBS CYCLE‐ASSOCIATED INTERMEDIATES IN THE RAT BRAIN

10.1111/j.1471-4159.1972.tb01310.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract— In order to study the influence of intracellular pH on the carbohydrate metabolism of brain tissue, the concentrations of glucose, glucose‐6‐phosphate, pyruvate, lactate, citrate, α‐oxoglutarate, malate, glutamate, aspartate and ammonia were measured in rats exposed to 6–40% CO2, for 45 min. Hypercapnia of increasing severity gave rise to progressive increases in the concentrations of glucose, glucose‐6‐phosphate and ammonium ion and to progressive decreases in the concentrations of all metabolic acids measured. The results fit with aH+ inhibition of a rate‐limiting step between glucose‐6‐phosphate and pyruvate, and by inference from the results published by others it may be assumed that this step is the phosphofructokinase reaction. Since the proportionally largest decrease occurred in a α‐oxoglutarate, the results might be compatible either with an inhibition of a second rate‐limiting step such as isocitrate dehydrogenase, or with a loss of α‐oxoglutarate through carboxylation to citrate.

Bibliography

FolbergrovÃ¡, J., MacMillan, V., & SiesjÃ¶, B. K. (1972). THE EFFECT OF HYPERCAPNIC ACIDOSIS UPON SOME GLYCOLYTIC AND KREBS CYCLEâASSOCIATED INTERMEDIATES IN THE RAT BRAIN. Journal of Neurochemistry, 19(11), 2507â2517. Portico.

Authors 3

Jaroslava Folbergrová (first)
V. MacMillan (additional)
B. K. Siesjö (additional)

References 31 Referenced 169

10.1152/ajplegacy.1949.158.3.478 / Am. J. Physiol. by Bain J. A. (1949)
{'key': 'e_1_2_1_3_1', 'first-page': '1', 'volume-title': 'Handbook of Neurochemistry', 'author': 'Balázs R', 'year': '1970'} / Handbook of Neurochemistry by Balázs R (1970)
{'key': 'e_1_2_1_4_1', 'first-page': '183', 'volume-title': 'CO2: Chemical, Biochemical, and Physiological Aspects', 'author': 'Cooper T. G.', 'year': '1969'} / CO2: Chemical, Biochemical, and Physiological Aspects by Cooper T. G. (1969)
{'key': 'e_1_2_1_5_1', 'first-page': '287', 'volume-title': 'Control of Energy Metabolism', 'author': 'Danforth W. H.', 'year': '1968'} / Control of Energy Metabolism by Danforth W. H. (1968)
10.1016/0304-4165(66)90114-0
10.1111/j.1471-4159.1972.tb01417.x
10.1111/j.1471-4159.1969.tb05937.x
10.1111/j.1471-4159.1972.tb01309.x
10.1016/S0021-9258(18)99802-9 / J. biol. Chem. by Goldberg N. D. (1966)
10.1111/j.1748-1716.1969.tb04379.x
{'key': 'e_1_2_1_12_1', 'first-page': '240', 'volume': '73', 'author': 'Hastings A. B.', 'year': '1960', 'journal-title': 'Trans. Ass. Am. Physns'} / Trans. Ass. Am. Physns by Hastings A. B. (1960)
10.3109/00365517109095711
10.1172/JCI101994
10.1111/j.1748-1716.1969.tb04495.x
10.3109/13813456709089579
{'key': 'e_1_2_1_17_1', 'first-page': '887', 'volume': '25', 'author': 'Longmore W. J.', 'year': '1966', 'journal-title': 'Fedn Proc. Fedn Am. Socs exp. Biol.'} / Fedn Proc. Fedn Am. Socs exp. Biol. by Longmore W. J. (1966)
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10.1016/S0021-9258(18)51740-3
10.1111/j.1471-4159.1964.tb11607.x
10.1111/j.1748-1716.1971.tb05087.x
10.1007/BF00234348
10.1152/ajplegacy.1967.212.4.864 / Am. J. Physiol. by Posner J. B. (1967)
10.1152/ajplegacy.1967.213.5.1143
10.1016/S0016-5085(19)34154-X / Gastroenterology by Shorey J. (1967)
{'key': 'e_1_2_1_26_1', 'first-page': '244', 'volume-title': 'Ion Homeostasis of the Brain', 'author': 'Siesjö B. K.', 'year': '1971'} / Ion Homeostasis of the Brain by Siesjö B. K. (1971)
10.1111/j.1471-4159.1972.tb01308.x
{'key': 'e_1_2_1_28_1', 'volume-title': 'CO2 and Metabolism', 'author': 'Siesjö B. K.', 'year': '1972'} / CO2 and Metabolism by Siesjö B. K. (1972)
10.1097/00000542-196011000-00011
10.1111/j.1471-4159.1964.tb06117.x
{'key': 'e_1_2_1_31_1', 'first-page': '352', 'volume-title': 'Ion Homeostasis of the Brain', 'author': 'Weyne J.', 'year': '1971'} / Ion Homeostasis of the Brain by Weyne J. (1971)
{'key': 'e_1_2_1_32_1', 'first-page': '435', 'volume-title': 'Methods in Enzymology, Vol. XIII: Citric Acid Cycle', 'author': 'Williamson J. R.', 'year': '1969'} / Methods in Enzymology, Vol. XIII: Citric Acid Cycle by Williamson J. R. (1969)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 4, 2006, 10:57 p.m.)
Deposited	1 year, 10 months ago (Oct. 8, 2023, 1:47 a.m.)
Indexed	2 days, 9 hours ago (Aug. 23, 2025, 1:02 a.m.)
Issued	52 years, 9 months ago (Nov. 1, 1972)
Published	52 years, 9 months ago (Nov. 1, 1972)
Published Online	18 years, 10 months ago (Oct. 4, 2006)
Published Print	52 years, 9 months ago (Nov. 1, 1972)

Funders 0

None

BibTeX

@article{Folbergrov__1972, title={THE EFFECT OF HYPERCAPNIC ACIDOSIS UPON SOME GLYCOLYTIC AND KREBS CYCLE‐ASSOCIATED INTERMEDIATES IN THE RAT BRAIN}, volume={19}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1972.tb01310.x}, DOI={10.1111/j.1471-4159.1972.tb01310.x}, number={11}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Folbergrová, Jaroslava and MacMillan, V. and Siesjö, B. K.}, year={1972}, month=nov, pages={2507–2517} }

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