DOI: 10.1111/j.1471-4159.1971.tb00002.x. CHANGES IN FREE FATTY ACIDS OF BRAIN BY DRUG‐INDUCED CONVULSIONS, ELECTROSHOCK AND ANAESTHESIA

CHANGES IN FREE FATTY ACIDS OF BRAIN BY DRUG‐INDUCED CONVULSIONS, ELECTROSHOCK AND ANAESTHESIA

10.1111/j.1471-4159.1971.tb00002.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract— The size of the free fatty acid pool in rat brain was significantly increased following convulsions induced by pentylenetetrazol as well as by electroconvulsive shock. Other convulsants such as d‐methionine‐dl‐sulphoximine and the dibutyryl analog of adenosine 3′,5′‐monophosphate did not alter the levels of free fatty acids.Diethyl ether anaesthesia suppressed the stimulatory effect of electroshock on the generation of free fatty acids in brain, but the effect was not seen with the anaesthetic pentobarbitone sodium. The lack of an inhibitory effect of either anaesthetic on the free fatty acid production which was induced in brain by ischaemia supported the view that the action of electroshock was not merely the result of anoxia.The prominent increase in size of the free fatty acid pool in brain thus appeared to be specific for electroshock‐ and pentylenetetrazol‐convulsed rats.We have proposed that the changes in the free fatty acids might be involved in the regulation of membrane functioning.

Bibliography

BazÃ¡n, N. G. (1971). CHANGES IN FREE FATTY ACIDS OF BRAIN BY DRUGâINDUCED CONVULSIONS, ELECTROSHOCK AND ANAESTHESIA. Journal of Neurochemistry, 18(8), 1379â1385. Portico.

Authors 1

N. G. Bazán (first)

References 23 Referenced 163

10.1111/j.1471-4159.1971.tb00003.x
10.1016/0005-2760(70)90086-X
{'key': 'e_1_2_2_4_1', 'first-page': '751', 'volume': '11', 'author': 'Bazán N. G.', 'year': '1968', 'journal-title': 'Fedn Proc, Fedn Am. Socs exp. Biol.'} / Fedn Proc, Fedn Am. Socs exp. Biol. by Bazán N. G. (1968)
10.1016/S0022-2275(20)43015-9 / J Lipid Res. by Bazán N. G. (1970)
10.1016/0024-3205(70)90205-5
{'key': 'e_1_2_2_7_1', 'first-page': '1', 'volume': '20', 'author': 'Bergstrom S.', 'year': '1968', 'journal-title': 'Pharmac. Rev.'} / Pharmac. Rev. by Bergstrom S. (1968)
10.1021/bi00876a022
10.1016/S0021-9258(18)95888-6 / J biol. Chem. by Robertis E. (1967)
10.1016/S0021-9258(18)64849-5
10.1016/S0021-9258(18)94453-4
10.1016/0005-2728(68)90072-8
10.1113/jphysiol.1969.sp008863
10.1016/0005-2736(69)90062-5
10.1073/pnas.58.3.1249
10.1016/0005-2760(68)90168-9
10.1111/j.1748-1716.1959.tb01739.x
10.1016/0005-2760(68)90114-8
10.1016/0005-2736(68)90074-6
10.1016/0024-3205(66)90129-9
10.1073/pnas.65.4.1033
{'key': 'e_1_2_2_22_1', 'first-page': '380', 'volume': '148', 'author': 'Somjem G. G.', 'year': '1965', 'journal-title': 'J Pharmac. exp. Ther.'} / J Pharmac. exp. Ther. by Somjem G. G. (1965)
{'key': 'e_1_2_2_23_1', 'first-page': '225', 'volume-title': 'Neurochemistry of Epilepsy', 'author': 'Tower D. B.', 'year': '1960'} / Neurochemistry of Epilepsy by Tower D. B. (1960)
10.1016/0005-2760(68)90169-0

Dates

Type	When
Created	18 years, 11 months ago (Oct. 4, 2006, 10:50 p.m.)
Deposited	1 year, 10 months ago (Nov. 4, 2023, 11:44 a.m.)
Indexed	14 hours, 39 minutes ago (Sept. 4, 2025, 10:07 a.m.)
Issued	54 years, 1 month ago (Aug. 1, 1971)
Published	54 years, 1 month ago (Aug. 1, 1971)
Published Online	18 years, 11 months ago (Oct. 4, 2006)
Published Print	54 years, 1 month ago (Aug. 1, 1971)

Funders 0

None

BibTeX

@article{Baz_n_1971, title={CHANGES IN FREE FATTY ACIDS OF BRAIN BY DRUG‐INDUCED CONVULSIONS, ELECTROSHOCK AND ANAESTHESIA}, volume={18}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1971.tb00002.x}, DOI={10.1111/j.1471-4159.1971.tb00002.x}, number={8}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Bazán, N. G.}, year={1971}, month=aug, pages={1379–1385} }

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