DOI: 10.1111/j.1471-4159.1970.tb03726.x. EFFECTS OF COLCHICINE ON AXONAL TRANSPORT IN PERIPHERAL NERVES

EFFECTS OF COLCHICINE ON AXONAL TRANSPORT IN PERIPHERAL NERVES

10.1111/j.1471-4159.1970.tb03726.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract—Colchicine injected intracisternally markedly inhibited the rapid migration (300‐400 mm/day) of labelled proteins in the hypoglossal and vagus nerve of the rabbit. The transport of acetylcholinesterase (EC 3.1.1.7) and choline acetyltransferase (EC 2.3.1.6) previously shown to move with the slow (5‐26 mm/day) phase of axoplasmic transport in these nerves, was only partially blocked. In view of this differential effect on axonal flow, we suggest that the neurotubules, on which colchicine acts preferentially, are primarily involved in the rapid (300‐400 mm/day) axoplasmic flow. After local injection of colchicine into the nerves both the rapidly migrating labelled proteins and the enzymes (AChE and ChAc) accumulated above the site of injection to the same degree as they accumulate above a nerve ligation. Since this blockage of enzyme transport occurred after concentrations of colchicine much higher than those used for intracisternal injections these findings after local injection may represent more severe effects on axonal transport systems.

Bibliography

SjÃ¶strand, J., Frizell, M., & Hasselgren, P. âO. (1970). EFFECTS OF COLCHICINE ON AXONAL TRANSPORT IN PERIPHERAL NERVES. Journal of Neurochemistry, 17(11), 1563â1570. Portico.

Authors 3

J. Sjöstrand (first)
M. Frizell (additional)
P.‐O. Hasselgren (additional)

References 23 Referenced 77

10.1002/jez.1401360209
{'key': 'e_1_2_1_3_1', 'first-page': '307', 'volume': '5', 'author': 'Barondes S. H.', 'year': '1967', 'journal-title': 'Neurosci. Res. Progr. Bull.'} / Neurosci. Res. Progr. Bull. by Barondes S. H. (1967)
10.1083/jcb.34.2.525
10.1111/j.1748-1716.1967.tb03507.x
10.1016/0014-2999(68)90165-9
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{'key': 'e_1_2_1_17_1', 'first-page': '121', 'volume': '27', 'author': 'Peterson E. R.', 'year': '1968', 'journal-title': 'J. Neuropath. exp. Neurol.'} / J. Neuropath. exp. Neurol. by Peterson E. R. (1968)
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 4, 2006, 10:14 p.m.)
Deposited	1 year, 9 months ago (Nov. 4, 2023, 4:47 p.m.)
Indexed	4 months, 2 weeks ago (April 8, 2025, 9:59 p.m.)
Issued	54 years, 9 months ago (Nov. 1, 1970)
Published	54 years, 9 months ago (Nov. 1, 1970)
Published Online	18 years, 10 months ago (Oct. 4, 2006)
Published Print	54 years, 9 months ago (Nov. 1, 1970)

Funders 0

None

BibTeX

@article{Sj_strand_1970, title={EFFECTS OF COLCHICINE ON AXONAL TRANSPORT IN PERIPHERAL NERVES}, volume={17}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1970.tb03726.x}, DOI={10.1111/j.1471-4159.1970.tb03726.x}, number={11}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Sjöstrand, J. and Frizell, M. and Hasselgren, P.‐O.}, year={1970}, month=nov, pages={1563–1570} }

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