DOI: 10.1111/j.1471-4159.1966.tb04281.x. BIOCHEMICAL CHANGES IN THE BRAIN IN RATS POISONED WITH AN ALKYLMERCURY COMPOUND, WITH SPECIAL REFERENCE TO THE INHIBITION OF PROTEIN SYNTHESIS IN BRAIN CORTEX SLICES

BIOCHEMICAL CHANGES IN THE BRAIN IN RATS POISONED WITH AN ALKYLMERCURY COMPOUND, WITH SPECIAL REFERENCE TO THE INHIBITION OF PROTEIN SYNTHESIS IN BRAIN CORTEX SLICES

10.1111/j.1471-4159.1966.tb04281.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

SUMMARYThe incorporation of [U‐14C]leucine into the protein of brain cortex slices from rats poisoned with methylmercury thioacetamide was markedly inhibited before the development of neurological symptoms and when the oxygen consumption, aerobic and anaerobic glycolysis and sulphydryl enzyme activities were unchanged.After the appearance of neurological symptoms, the oxygen consumption decreased significantly, while lactic acid formation did not change under anaerobic conditions, but slightly decreased under aerobic conditions.The activities of the three sulphydryl enzymes (Mg‐activated ATPase, fructose‐ diphosphate aldolase and succinate dehydrogenase) were almost the same in visual cortex, motor cortex, cerebellum and caudate nucleus, while the activities of Mg‐activated ATPase and succinate dehydrogenase in the white matter were lower than that in the grey matter. There was no difference in the activity of fructosediphosphate aldolase in grey and white matter. The activities of all three enzymes did not show any change in the earlier stage of poisoning when the animal remained free from neurological symptoms. At the more advanced stage, when neurological symptoms were present, only the activity of the succinate dehydrogenase decreased significantly, while the activities of the other two enzymes remained unchanged.The selective inhibition of protein synthesis may have a direct bearing on the poisoning by the alkylmercury compound.

Bibliography

Yoshino, Y., Mozai, T., & Nakao, K. (1966). BIOCHEMICAL CHANGES IN THE BRAIN IN RATS POISONED WITH AN ALKYLMERCURY COMPOUND, WITH SPECIAL REFERENCE TO THE INHIBITION OF PROTEIN SYNTHESIS IN BRAIN CORTEX SLICES. Journal of Neurochemistry, 13(11), 1223â1230. Portico.

Authors 3

Yoshikazu Yoshino (first)
Toshiji Mozai (additional)
Kiku Nakao (additional)

References 25 Referenced 145

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{'key': 'e_1_2_1_5_1', 'first-page': '34', 'volume': '9', 'author': 'Brown W. J.', 'year': '1965', 'journal-title': 'Adv. Neurol. Sci. (Shinkeikenkyu no Shinpo)'} / Adv. Neurol. Sci. (Shinkeikenkyu no Shinpo) by Brown W. J. (1965)
10.1111/j.1471-4159.1962.tb09451.x
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10.1111/j.1471-4159.1966.tb06816.x

Dates

Type	When
Created	18 years, 10 months ago (Oct. 4, 2006, 9:37 p.m.)
Deposited	1 year, 9 months ago (Nov. 4, 2023, 6:56 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 9, 2024, 12:33 a.m.)
Issued	58 years, 9 months ago (Nov. 1, 1966)
Published	58 years, 9 months ago (Nov. 1, 1966)
Published Online	18 years, 10 months ago (Oct. 4, 2006)
Published Print	58 years, 9 months ago (Nov. 1, 1966)

Funders 0

None

BibTeX

@article{Yoshino_1966, title={BIOCHEMICAL CHANGES IN THE BRAIN IN RATS POISONED WITH AN ALKYLMERCURY COMPOUND, WITH SPECIAL REFERENCE TO THE INHIBITION OF PROTEIN SYNTHESIS IN BRAIN CORTEX SLICES}, volume={13}, ISSN={1471-4159}, url={http://dx.doi.org/10.1111/j.1471-4159.1966.tb04281.x}, DOI={10.1111/j.1471-4159.1966.tb04281.x}, number={11}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Yoshino, Yoshikazu and Mozai, Toshiji and Nakao, Kiku}, year={1966}, month=nov, pages={1223–1230} }

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