DOI: 10.1111/j.1469-7793.1999.0317t.x. Aquaporin water channels in gastrointestinal physiology

Aquaporin water channels in gastrointestinal physiology

10.1111/j.1469-7793.1999.0317t.x

Crossref journal-article

Wiley

The Journal of Physiology (311)

Abstract

Fluid transport is a major function of the gastrointestinal (GI) tract with more than 9 litres of fluid being absorbed or secreted across epithelia in human salivary gland, stomach, the hepatobiliary tract, pancreas, small intestine and colon. This review evaluates the evidence that aquaporin‐type water channels are involved in GI fluid transport. The aquaporins are a family of small (≈30 kDa) integral membrane proteins that function as water channels. At least seven aquaporins are expressed in various tissues in the GI tract: AQP1 in intrahepatic cholangiocytes, AQP4 in gastric parietal cells, AQP3 and AQP4 in colonic surface epithelium, AQP5 in salivary gland, AQP7 in small intestine, AQP8 in liver, pancreas and colon, and AQP9 in liver. There are functional data suggesting that some GI cell types expressing aquaporins have high or regulated water permeability; however, there has been no direct evidence for a role of aquaporins in GI physiology. Recently, transgenic mice have been generated with selective deletions of various aquaporins. Preliminary evaluation of GI function suggests a role for AQP1 in dietary fat processing and AQP4 in colonic fluid absorption. Further study of aquaporin function in the GI tract should provide new insights into normal GI physiology and disease mechanisms, and may yield novel therapies to regulate fluid movement in GI diseases.

Bibliography

Ma, T., & Verkman, A. S. (1999). Aquaporin water channels in gastrointestinal physiology. The Journal of Physiology, 517(2), 317â326. Portico.

Authors 2

Tonghui Ma (first)
A. S. Verkman (additional)

References 76 Referenced 226

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Dates

Type	When
Created	20 years, 11 months ago (Sept. 8, 2004, 3:19 a.m.)
Deposited	2 years ago (Aug. 30, 2023, 9:10 a.m.)
Indexed	3 weeks, 6 days ago (Aug. 3, 2025, 7:05 p.m.)
Issued	26 years, 2 months ago (June 1, 1999)
Published	26 years, 2 months ago (June 1, 1999)
Published Online	20 years, 11 months ago (Sept. 8, 2004)
Published Print	26 years, 2 months ago (June 1, 1999)

Funders 0

None

BibTeX

@article{Ma_1999, title={Aquaporin water channels in gastrointestinal physiology}, volume={517}, ISSN={1469-7793}, url={http://dx.doi.org/10.1111/j.1469-7793.1999.0317t.x}, DOI={10.1111/j.1469-7793.1999.0317t.x}, number={2}, journal={The Journal of Physiology}, publisher={Wiley}, author={Ma, Tonghui and Verkman, A. S.}, year={1999}, month=jun, pages={317–326} }

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