DOI: 10.1111/j.1469-1809.1992.tb01136.x. Dominant genes for colorectal cancer are not rare

Dominant genes for colorectal cancer are not rare

10.1111/j.1469-1809.1992.tb01136.x

Crossref journal-article

Wiley

Annals of Human Genetics (311)

Abstract

SummaryThe genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0·006 with a lifetime penetrance of 0·63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.

Bibliography

HOULSTON, R. S., COLLINS, A., SLACK, J., & MORTON, N. E. (1992). Dominant genes for colorectal cancer are not rare. Annals of Human Genetics, 56(2), 99â103. Portico.

Authors 4

R. S. HOULSTON (first)
A. COLLINS (additional)
J. SLACK (additional)
N. E. MORTON (additional)

References 19 Referenced 96

10.1016/S0300-5089(21)00056-0 / Clinics in Gastroenterology / The intestinal polyposes by Alma T. (1973)
10.1002/gepi.1370030104
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10.1126/science.2294591
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10.1111/j.1469-1809.1991.tb00408.x
10.1126/science.1651562
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10.1002/bjs.1800630103
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10.1007/BF02555012
{'key': 'e_1_2_1_14_1', 'first-page': '62', 'volume-title': 'Methods in Genetic Epidemiology', 'author': 'Morton N. E.', 'year': '1983'} / Methods in Genetic Epidemiology by Morton N. E. (1983)
{'key': 'e_1_2_1_15_1', 'first-page': '51', 'article-title': 'Problems in the estimation of the frequency of uncommon inherited traits', 'volume': '6', 'author': 'Neel J. V.', 'year': '1954', 'journal-title': 'Am. J. Hum. Genetics'} / Am. J. Hum. Genetics / Problems in the estimation of the frequency of uncommon inherited traits by Neel J. V. (1954)
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{'volume-title': 'England and Wales', 'year': '1970', 'author': 'Office of Population Censuses and Surveys', 'key': 'e_1_2_1_19_1'} / England and Wales by Office of Population Censuses and Surveys (1970)
10.1056/NEJM198809013190901

Dates

Type	When
Created	17 years, 11 months ago (Sept. 28, 2007, 1:58 a.m.)
Deposited	1 year, 9 months ago (Nov. 20, 2023, 3:37 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 6, 2025, 8:09 a.m.)
Issued	33 years, 4 months ago (May 1, 1992)
Published	33 years, 4 months ago (May 1, 1992)
Published Online	17 years, 11 months ago (Sept. 28, 2007)
Published Print	33 years, 4 months ago (May 1, 1992)

Funders 0

None

BibTeX

@article{HOULSTON_1992, title={Dominant genes for colorectal cancer are not rare}, volume={56}, ISSN={1469-1809}, url={http://dx.doi.org/10.1111/j.1469-1809.1992.tb01136.x}, DOI={10.1111/j.1469-1809.1992.tb01136.x}, number={2}, journal={Annals of Human Genetics}, publisher={Wiley}, author={HOULSTON, R. S. and COLLINS, A. and SLACK, J. and MORTON, N. E.}, year={1992}, month=may, pages={99–103} }

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