DOI: 10.1111/j.1464-5491.1995.tb02058.x. Undiagnosed Glucose Intolerance in the Community: the Isle of Ely Diabetes Project

Undiagnosed Glucose Intolerance in the Community: the Isle of Ely Diabetes Project

10.1111/j.1464-5491.1995.tb02058.x

Crossref journal-article

Wiley

Diabetic Medicine (311)

Abstract

The Isle of Ely Diabetes Project is a prospective population‐based study of the aetiology and pathogenesis of Type 2 diabetes mellitus. Between 1990 and 1992, 1156 subjects aged between 40 and 65 years underwent a standard 75 g oral glucose tolerance test (OGTT). A total of 1122 individuals who were not known to have diabetes completed the test and were classified according to WHO criteria; 51 subjects (4.5%) had previously undiagnosed diabetes and 188 (16.7%) had impaired glucose tolerance. The subjects with newly diagnosed glucose intolerance were significantly older, more obese, and shorter than those with normal glucose tolerance. Blood pressure, cholesterol, triglyceride, and LDL‐cholesterol concentrations were elevated and HDL‐cholesterol levels were lower among those with abnormal rather than normal glucose tolerance. In multiple regression analyses stratified by gender and including age, body mass index, and the waist‐hip ratio as covariates, there were significant differences between those with normal and abnormal glucose intolerance in blood pressure, triglyceride, and HDL‐cholesterol, but not total or LDL‐cholesterol. In both male and female subjects, height had a significant independent negative association with the plasma glucose at 120 min after administration of oral glucose (standardized β coefficient = ‐0.12, p<0.01).

Bibliography

Williams, D. R. R., Wareham, N. J., Brown, D. C., Byrne, C. D., Clark, P. M. S., Cox, B. D., Cox, L. J., Day, N. E., Hales, C. N., Palmer, C. R., Shackleton, J. R., & Wang, T. W. M. (1995). Undiagnosed Glucose Intolerance in the Community: the Isle of Ely Diabetes Project. Diabetic Medicine, 12(1), 30â35. Portico.

Authors 12

D. R. R. Williams (first)
N. J. Wareham (additional)
D. C. Brown (additional)
C. D. Byrne (additional)
P. M. S. Clark (additional)
B. D. Cox (additional)
L. J. Cox (additional)
N. E. Day (additional)
C. N. Hales (additional)
C. R. Palmer (additional)
J. R. Shackleton (additional)
T. W. M. Wang (additional)

References 26 Referenced 118

10.1111/j.1464-5491.1988.tb01117.x
10.1111/j.1464-5491.1987.tb00926.x
{'key': 'e_1_2_1_4_2', 'volume-title': 'Diabetes Mellitus', 'author': 'World Health Organization Study Group', 'year': '1985'} / Diabetes Mellitus by World Health Organization Study Group (1985)
10.1136/bmj.303.6794.95-a
10.1007/BF00403292
{'key': 'e_1_2_1_7_2', 'volume-title': 'Anthropometric Standardization Reference Manual', 'author': 'Lohman TG', 'year': '1988'} / Anthropometric Standardization Reference Manual by Lohman TG (1988)
10.1093/clinchem/18.6.499
{'key': 'e_1_2_1_9_2', 'volume-title': 'Statistical Models in Epidemiology', 'author': 'Clayton D', 'year': '1993'} / Statistical Models in Epidemiology by Clayton D (1993)
10.2337/diab.40.7.796 / Diabetes / Risk factors for NIDDM in white population. Paris Prospective Study by Charles MA (1991)
10.1136/bmj.303.6805.755
10.1007/BF00277480
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10.1136/bmj.303.6809.1019
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10.1093/oxfordjournals.aje.a114574 / Am J Epidemiol / Plasma insulin and serum lipids and lipoproteins in middle‐aged non‐insulin‐dependent diabetic and non‐diabetic subjects by Laakso M (1987)
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10.1161/01.ATV.9.5.665
10.1136/bmj.305.6861.1057
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Dates

Type	When
Created	16 years, 1 month ago (July 30, 2009, 7:50 a.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 10:36 p.m.)
Indexed	5 months ago (April 3, 2025, 4:22 a.m.)
Issued	30 years, 8 months ago (Jan. 1, 1995)
Published	30 years, 8 months ago (Jan. 1, 1995)
Published Online	16 years, 1 month ago (July 30, 2009)
Published Print	30 years, 8 months ago (Jan. 1, 1995)

Funders 0

None

BibTeX

@article{Williams_1995, title={Undiagnosed Glucose Intolerance in the Community: the Isle of Ely Diabetes Project}, volume={12}, ISSN={1464-5491}, url={http://dx.doi.org/10.1111/j.1464-5491.1995.tb02058.x}, DOI={10.1111/j.1464-5491.1995.tb02058.x}, number={1}, journal={Diabetic Medicine}, publisher={Wiley}, author={Williams, D. R. R. and Wareham, N. J. and Brown, D. C. and Byrne, C. D. and Clark, P. M. S. and Cox, B. D. and Cox, L. J. and Day, N. E. and Hales, C. N. and Palmer, C. R. and Shackleton, J. R. and Wang, T. W. M.}, year={1995}, month=jan, pages={30–35} }

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