DOI: 10.1111/j.1460-9568.1997.tb01346.x. Connexins, Gap Junctions and Cell‐Cell Signalling in the Nervous System

Connexins, Gap Junctions and Cell‐Cell Signalling in the Nervous System

10.1111/j.1460-9568.1997.tb01346.x

Crossref journal-article

Wiley

European Journal of Neuroscience (311)

Abstract

AbstractConnexins form a multigene family of polytopic membrane proteins that, in vertebrates, are the constitutive subunits of intercellular channels and provide the structural basis for electrical coupling. The appearance of electrical coupling in the nervous system is developmentally regulated and restricted to distinct cell types. Electrical coupling between neurons persists after the establishment of chemical transmission, thus suggesting that this form of cell‐cell signalling may be functionally interrelated with, rather than alternative to chemical transmission. Furthermore, evidence for the possible role of gap junctions in human neurological diseases is also mounting, following the discovery that the X‐linked form of Charcot‐Marie‐Tooth syndrome, a demyelinating neuropathy of the peripheral nervous system, is associated with mutations in a connexin gene. These findings raise new questions on the significance of connexin diversity and on their functional role in the nervous system.

Bibliography

Bruzzone, R., & Ressot, C. (1997). Connexins, Gap Junctions and CellâCell Signalling in the Nervous System. European Journal of Neuroscience, 9(1), 1â6. Portico.

Authors 2

Roberto Bruzzone (first)
Catherine Ressot (additional)

References 25 Referenced 77

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Dates

Type	When
Created	19 years, 4 months ago (April 7, 2006, 10:26 p.m.)
Deposited	1 year, 11 months ago (Oct. 3, 2023, 7:03 a.m.)
Indexed	1 year, 4 months ago (May 6, 2024, 1:17 p.m.)
Issued	28 years, 8 months ago (Jan. 1, 1997)
Published	28 years, 8 months ago (Jan. 1, 1997)
Published Online	19 years, 5 months ago (April 7, 2006)
Published Print	28 years, 8 months ago (Jan. 1, 1997)

Funders 0

None

BibTeX

@article{Bruzzone_1997, title={Connexins, Gap Junctions and Cell‐Cell Signalling in the Nervous System}, volume={9}, ISSN={1460-9568}, url={http://dx.doi.org/10.1111/j.1460-9568.1997.tb01346.x}, DOI={10.1111/j.1460-9568.1997.tb01346.x}, number={1}, journal={European Journal of Neuroscience}, publisher={Wiley}, author={Bruzzone, Roberto and Ressot, Catherine}, year={1997}, month=jan, pages={1–6} }

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