DOI: 10.1111/j.1460-9568.1996.tb01325.x. Involvement of <i>p53</i> in DNA Strand Break‐induced Apoptosis in Postmitotic CNS Neurons

Involvement of p53 in DNA Strand Break‐induced Apoptosis in Postmitotic CNS Neurons

10.1111/j.1460-9568.1996.tb01325.x

Crossref journal-article

Wiley

European Journal of Neuroscience (311)

Abstract

AbstractThe tumour suppressor p53 gene serves as a critical regulator of the cell cycle and of apoptosis following the exposure of normal cells to DNA damage. To examine the role of p53 in postmitotic CNS neurons, we cultured cerebellar neurons from normal wild‐type mice and mutant p53‐null mice under various conditions inducing neuronal death. When cerebellar neurons from 15‐ to 16‐day postnatal wild‐type mice were treated with ionizing radiation or DNA‐damaging agents, massive neuron death occurred after 24‐72 h. In contrast, neurons from p53+ mice evidently resisted γ‐irradiation and some DNA‐damaging agents, such as etoposide and bleomycin. On the other hand, low‐K+ medium‐induced apoptosis of cerebellar neurons was not affected by p53 status. Neither cell cycle progression nor DNA synthesis occurred during cell death induced by γ‐irradiation and low‐K+ medium, as well as in normal cultures of p53+/+ and p53‐/‐ neurons. These results suggest that p53 is required for the apoptotic death of postmitotic cerebellar neurons induced by DNA strand breaks.

Bibliography

Enokido, Y., Araki, T., Tanaka, K., Aizawa, S., & Hatanaka, H. (1996). Involvement of p53 in DNA Strand Breakâinduced Apoptosis in Postmitotic CNS Neurons. European Journal of Neuroscience, 8(9), 1812â1821. Portico.

Authors 5

Yasushi Enokido (first)
Toshiyuki Araki (additional)
Kiyoji Tanaka (additional)
Shinichi Aizawa (additional)
Hiroshi Hatanaka (additional)

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Dates

Type	When
Created	19 years, 4 months ago (April 7, 2006, 10:19 p.m.)
Deposited	1 year, 10 months ago (Oct. 27, 2023, 5:24 p.m.)
Indexed	1 month, 4 weeks ago (July 7, 2025, 1:45 a.m.)
Issued	29 years ago (Sept. 1, 1996)
Published	29 years ago (Sept. 1, 1996)
Published Online	19 years, 4 months ago (April 7, 2006)
Published Print	29 years ago (Sept. 1, 1996)

Funders 0

None

BibTeX

@article{Enokido_1996, title={Involvement of p53 in DNA Strand Break‐induced Apoptosis in Postmitotic CNS Neurons}, volume={8}, ISSN={1460-9568}, url={http://dx.doi.org/10.1111/j.1460-9568.1996.tb01325.x}, DOI={10.1111/j.1460-9568.1996.tb01325.x}, number={9}, journal={European Journal of Neuroscience}, publisher={Wiley}, author={Enokido, Yasushi and Araki, Toshiyuki and Tanaka, Kiyoji and Aizawa, Shinichi and Hatanaka, Hiroshi}, year={1996}, month=sep, pages={1812–1821} }

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