DOI: 10.1111/j.1460-9568.1995.tb01132.x. Truncated and Catalytic Isoforms of trkB are Co‐expressed in Neurons of Rat and Mouse CNS

Truncated and Catalytic Isoforms of trkB are Co‐expressed in Neurons of Rat and Mouse CNS

10.1111/j.1460-9568.1995.tb01132.x

Crossref journal-article

Wiley

European Journal of Neuroscience (311)

Abstract

AbstractLocalization of mRNA encoding trkB indicates that two truncated isoforms of trkB, T1trkB and T2trkB, are differentially distributed in the rodent nervous system, and that each of these transcripts is co‐expressed with catalytic trkB (TK+trkB) in adult motor neurons. In contrast to the prominent expression of T1trkB by non‐neuronal cells, T2trkB expression appeared to be restricted to neurons and demonstrated significant overlap with the pattern of TK+trkB distribution. In developing spinal cord ventral horn, an age‐related increase in hybridization was observed for truncated isoforms. These findings suggest that truncated trkB may modulate neuronal responses to neurotrophins which act via trkB.

Bibliography

Armanini, M. P., McMahon, S. B., Sutherland, J., Shelton, D. L., & Phillips, H. S. (1995). Truncated and Catalytic Isoforms of trkB are Coâexpressed in Neurons of Rat and Mouse CNS. European Journal of Neuroscience, 7(6), 1403â1409. Portico.

Authors 5

M. P. Armanini (first)
S. B. McMahon (additional)
J. Sutherland (additional)
D. L. Shelton (additional)
H. S. Phillips (additional)

References 22 Referenced 102

10.1016/0306-4522(94)90507-X
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10.1523/JNEUROSCI.13-09-04001.1993
10.1016/0092-8674(91)90149-S
10.1523/JNEUROSCI.14-04-02054.1994
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10.1016/0896-6273(92)90066-M
10.1126/science.1850549
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{'key': 'e_1_2_2_20_1', 'first-page': '141', 'article-title': 'trkB, a neural receptor protein‐tyrosine kinase: evidence for a full length and two truncated receptors', 'volume': '11', 'author': 'Middlemas D. S.', 'year': '1991', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / trkB, a neural receptor protein‐tyrosine kinase: evidence for a full length and two truncated receptors by Middlemas D. S. (1991)
10.1523/JNEUROSCI.15-01-00477.1995 / J. Neurosci. / Human trks: molecular cloning, tissue distribution and expression of extracellular domain immunoadhesins by Shelton D. L. (1995)
10.1016/0092-8674(91)90396-G
10.1016/0092-8674(91)90395-F

Dates

Type	When
Created	19 years, 4 months ago (April 7, 2006, 9:49 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 3:26 p.m.)
Indexed	1 year ago (Aug. 12, 2024, 11:53 a.m.)
Issued	30 years, 3 months ago (June 1, 1995)
Published	30 years, 3 months ago (June 1, 1995)
Published Online	19 years, 4 months ago (April 7, 2006)
Published Print	30 years, 3 months ago (June 1, 1995)

Funders 0

None

BibTeX

@article{Armanini_1995, title={Truncated and Catalytic Isoforms of trkB are Co‐expressed in Neurons of Rat and Mouse CNS}, volume={7}, ISSN={1460-9568}, url={http://dx.doi.org/10.1111/j.1460-9568.1995.tb01132.x}, DOI={10.1111/j.1460-9568.1995.tb01132.x}, number={6}, journal={European Journal of Neuroscience}, publisher={Wiley}, author={Armanini, M. P. and McMahon, S. B. and Sutherland, J. and Shelton, D. L. and Phillips, H. S.}, year={1995}, month=jun, pages={1403–1409} }

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