DOI: 10.1111/j.1460-9568.1994.tb00312.x. Positive Feedback between Acetylcholine and the Neurotrophins Nerve Growth Factor and Brain‐derived Neurotrophic Factor in the Rat Hippocampus

Positive Feedback between Acetylcholine and the Neurotrophins Nerve Growth Factor and Brain‐derived Neurotrophic Factor in the Rat Hippocampus

10.1111/j.1460-9568.1994.tb00312.x

Crossref journal-article

Wiley

European Journal of Neuroscience (311)

Abstract

AbstractIn the rat hippocampus, nerve growth factor (NGF) and brain‐derived neurotrophic factor (BDNF) are synthesized by neurons in an activity‐dependent manner. Glutamate receptor activation increases whereas GABAergic stimulation decreases NGF and BDNF mRNA levels. Here we demonstrate that NGF and BDNF mRNA and NGF protein are up‐regulated in the rat hippocampus by the activation of muscarinic receptors. Conversely, NGF and BDNF enhance the release of acetylcholine (ACh) from rat hippocampal synaptosomes containing the nerve endings of the septal cholinergic neurons. NGF also rapidly increases the high‐affinity choline transport into synaptosomes. The reciprocal regulation of ACh, NGF and BDNF in the hippocampus suggests a novel molecular framework by which the neurotrophins might influence synaptic plasticity.

Bibliography

Knipper, M., da Penha Berzaghi, M., BlÃ¶chl, A., Breer, H., Thoenen, H., & Lindholm, D. (1994). Positive Feedback between Acetylcholine and the Neurotrophins Nerve Growth Factor and Brainâderived Neurotrophic Factor in the Rat Hippocampus. European Journal of Neuroscience, 6(4), 668â671. Portico.

Authors 6

Marlies Knipper (first)
Maria da Penha Berzaghi (additional)
Andrea Blöchl (additional)
Heinz Breer (additional)
Hans Thoenen (additional)
Dan Lindholm (additional)

References 27 Referenced 247

10.1016/0896-6273(90)90166-D
10.1097/00001756-199309150-00004
10.1002/neu.480210202
10.1016/0304-3940(90)90382-J
10.1073/pnas.89.20.9444
10.1097/00001756-199307000-00014
10.1016/0003-2697(87)90021-2
10.1016/0006-8993(86)91464-2
10.1016/0896-6273(91)90084-D
10.1016/0006-8993(91)91409-T
10.1016/0169-328X(91)90136-L
10.1111/j.1432-1033.1992.tb16689.x
10.1523/JNEUROSCI.08-08-02967.1988 / J. Neurosci. / Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth and expression of transmitter‐specific enzymes by Hartikka J. (1988)
10.1016/0304-3940(92)90384-J
10.1097/00001756-199305000-00005
10.1073/pnas.88.3.961
10.1111/j.1471-4159.1978.tb07029.x
10.1007/BF02259130
10.1016/S0021-9258(18)37599-9 / J. Biol. Chem. / Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts by Lindholm D. (1988)
10.1038/363350a0
10.1016/0306-4522(92)90292-A
10.1113/jphysiol.1985.sp015644 / J. Physiol. / The early time course of potassium‐stimulated calcium uptake in presynaptic terminals isolated from rat brain by Nachsen D. A. (1985)
10.1016/0896-6273(92)90067-N
10.1111/j.1471-4159.1991.tb03795.x
10.1111/j.1460-9568.1990.tb00382.x
10.1002/j.1460-2075.1990.tb07564.x
10.1073/pnas.88.22.10037

Dates

Type	When
Created	19 years, 4 months ago (April 7, 2006, 9:21 p.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 8:50 p.m.)
Indexed	1 month, 1 week ago (July 26, 2025, 4:50 a.m.)
Issued	31 years, 5 months ago (April 1, 1994)
Published	31 years, 5 months ago (April 1, 1994)
Published Online	19 years, 4 months ago (April 7, 2006)
Published Print	31 years, 5 months ago (April 1, 1994)

Funders 0

None

BibTeX

@article{Knipper_1994, title={Positive Feedback between Acetylcholine and the Neurotrophins Nerve Growth Factor and Brain‐derived Neurotrophic Factor in the Rat Hippocampus}, volume={6}, ISSN={1460-9568}, url={http://dx.doi.org/10.1111/j.1460-9568.1994.tb00312.x}, DOI={10.1111/j.1460-9568.1994.tb00312.x}, number={4}, journal={European Journal of Neuroscience}, publisher={Wiley}, author={Knipper, Marlies and da Penha Berzaghi, Maria and Blöchl, Andrea and Breer, Heinz and Thoenen, Hans and Lindholm, Dan}, year={1994}, month=apr, pages={668–671} }

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