DOI: 10.1111/j.1460-9568.1990.tb00385.x. Neuropeptide Levels after Pentylenetetrazol Kindling in the Rat

Neuropeptide Levels after Pentylenetetrazol Kindling in the Rat

10.1111/j.1460-9568.1990.tb00385.x

Crossref journal-article

Wiley

European Journal of Neuroscience (311)

Abstract

AbstractLevels of several neuropeptides were measured in the frontal cortex, dorsal hippocampus, striatum, and amygdala/pyriform cortex in rats kindled for 5 weeks by daily injection of pentylenetetrazol (30 mg/kg, i.p.). Significantly increased concentrations (by 30–140%) were found in all examined brain areas for neuropeptide Y, somatostatin (except hippocampus) and neurokinin‐like immunoreactivity 10 days after the last kindling session. Similar but less pronounced changes were also found 24 h after the last seizure. The increase in total neurokinin‐like immunoreactivity was due to a marked increase in neurokinin B as revealed by HPLC analysis. Increases in peptide levels, however, were restricted to fully kindled animals. At the same time no changes in levels of substance P, vasoactive intestinal polypeptide and calcitonin gene‐regulated peptide were observed. Cholecystokinin octapeptide was enhanced only in the hippocampus (by 46%). The increases in neuropeptide Y, somatostatin, and neurokinin‐like immunoreactivity subsided after 3 months. A markedly decreased seizure threshold was observed 10 days and 2 months after the final kindling session.No nerve cell degeneration was observed in kindled rats 24 h or 10 days after the last pentylenetetrazol injection. Some animals (2 of 4), however, exhibited signs of blood‐brain barrier damage when examined 24 h after the last kindling session which may reflect the preceding convulsions. No such changes were detected after 10 days.The increases in peptide levels may suggest increased activity of respective neurons which, at least to some degree, may be associated with γ‐aminobutyric acid. The changes in peptide levels may be more closely related to the kindling procedure itself than to the decreased seizure threshold of the animals.

Bibliography

Marksteiner, J., Lassmann, H., Saria, A., Humpel, C., Meyer, D. K., & Sperk, G. (1990). Neuropeptide Levels after Pentylenetetrazol Kindling in the Rat. European Journal of Neuroscience, 2(1), 98â103. Portico.

Authors 6

Josef Marksteiner (first)
Hans Lassmann (additional)
Alois Saria (additional)
Christian Humpel (additional)
Dieter K. Meyer (additional)
Günther Sperk (additional)

References 40 Referenced 45

10.1016/0014-2999(84)90073-6
10.1016/0306-4522(85)90299-4
10.1002/cne.901660302
10.1016/0167-0115(86)90044-3
10.1038/309153a0
10.1523/JNEUROSCI.08-06-01852.1988 / J. Neurosci. / Seizures induce dramatic and distinctly different changes in enkephalin, Dynorphin, and CCK immunoreactivities in mouse hippocampal mossy fibers by Gall C. (1988)
10.1016/0028-3908(88)90139-6
10.1073/pnas.81.20.6526
10.1016/0006-8993(83)90118-X
10.1038/285231a0
10.1016/0006-8993(86)90738-9
10.1016/0166-2236(86)90026-3
10.1523/JNEUROSCI.06-10-03094.1986 / J. Neurosci. / Kainic acid alters the metabolism of met5‐enkephalin and the level of dynorphin A in the rat hippocampus by Kanamatsu T. (1986)
10.1016/0024-3205(83)90366-1
10.1016/0306-4522(85)90076-4
10.1007/BF00688294
10.1146/annurev.ne.11.030188.000305
10.1016/0306-4522(88)90155-8
10.1007/BF00165140
10.1016/0304-3940(86)90252-1
10.1016/0301-0082(86)90010-9
10.1111/j.2042-7158.1971.tb08739.x
10.1016/0301-0082(80)90006-4
10.1016/0304-3940(86)90605-1
10.1073/pnas.85.9.3226
10.1002/jnr.490160108
10.1002/syn.890040307
10.1002/ana.410210511
10.1016/0196-9781(88)90232-X
10.1016/0167-0115(89)90189-4
10.1016/0169-328X(89)90041-7
10.1523/JNEUROSCI.04-10-02590.1984
10.1016/0306-4522(83)90113-6
10.1111/j.1471-4159.1985.tb07211.x
10.1016/0306-4522(86)90081-3
10.1016/0306-4522(90)90315-U
10.1002/cne.902170303
10.1016/0304-3940(81)90054-9
10.1007/BF00686065
10.1523/JNEUROSCI.07-03-00753.1987 / J. Neurosci. / Enkephalin biosynthesis and enkephalin gene expression are increased in hippocampal mossy fibers following a unilateral lesion of the hilus by White J. D. (1987)

Dates

Type	When
Created	19 years, 4 months ago (April 7, 2006, 8:02 p.m.)
Deposited	1 year, 11 months ago (Sept. 25, 2023, 11:52 p.m.)
Indexed	1 year, 3 months ago (May 21, 2024, 5:08 p.m.)
Issued	35 years, 8 months ago (Jan. 1, 1990)
Published	35 years, 8 months ago (Jan. 1, 1990)
Published Online	19 years, 4 months ago (April 7, 2006)
Published Print	35 years, 8 months ago (Jan. 1, 1990)

Funders 0

None

BibTeX

@article{Marksteiner_1990, title={Neuropeptide Levels after Pentylenetetrazol Kindling in the Rat}, volume={2}, ISSN={1460-9568}, url={http://dx.doi.org/10.1111/j.1460-9568.1990.tb00385.x}, DOI={10.1111/j.1460-9568.1990.tb00385.x}, number={1}, journal={European Journal of Neuroscience}, publisher={Wiley}, author={Marksteiner, Josef and Lassmann, Hans and Saria, Alois and Humpel, Christian and Meyer, Dieter K. and Sperk, Günther}, year={1990}, month=jan, pages={98–103} }

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