DOI: 10.1111/j.1445-5994.1986.tb01148.x. BARRETT'S ESOPHAGUS: CLINICAL, ENDOSCOPIC, AND HISTOLOGIC SPECTRUM IN FIFTY PATIENTS

BARRETT'S ESOPHAGUS: CLINICAL, ENDOSCOPIC, AND HISTOLOGIC SPECTRUM IN FIFTY PATIENTS

10.1111/j.1445-5994.1986.tb01148.x

Crossref journal-article

Wiley

Australian and New Zealand Journal of Medicine (311)

Abstract

Abstract The columnar lined (Barrett's) esophagus is an acquired condition resulting from chronic gastroesophageal reflux. The clinical spectrum of 50 consecutive cases of endoscopically consistent, histologically proven Barrett's esophagus was reviewed. The mean age of patients was 65.9 ± 12.4 (SD) years with only four patients younger than 50 years. The predominant presenting symptoms were dysphagia, heartburn, and regurgitation. At endoscopy, the columnar lined segment extended over 6.5 ± 3.0 cm of the lower esophagus. Specialised columnar (intestinal) epithelium was the most frequent histological type identified. Radiologic or endoscopic evidence of a hiatal hernia was present in the majority. Complications were present at endoscopy in 38 (76%) patients. Reflux esophagitis (56%) was present at the area of the squamo‐columnar junction. Stricture formation (38%) and ulceration (36%) were located either at the squamo‐columnar junction or more distally within the columnar epithelium. Two patients (4%) had adenocarcinoma arising in a segment of Barrett's esophagus at presentation. Treatment included physical measures, dilatation, and cimetidine. Bougienage in 20 patients was successful in alleviating dysphagia but multiple treatment sessions were often necessary. Although esophagitis readily resolved with cimetidine therapy, ulceration was generally resistant to medical therapy. Indeed, by two months, healing was achieved in only five of 12 patients. Endoscopic surveillance of 12 patients who received cimetidine (1 g/day) for at least 12 months showed no regression of the metaplastic mucosa.

Bibliography

KERLIN, P., DâMELLOW, G., & VAN DETH, A. (1986). BARRETTâS ESOPHAGUS: CLINICAL, ENDOSCOPIC, AND HISTOLOGIC SPECTRUM IN FIFTY PATIENTS. Australian and New Zealand Journal of Medicine, 16(2), 198â205. Portico.

Authors 3

P. KERLIN (first)
G. D'MELLOW (additional)
A. VAN DETH (additional)

References 26 Referenced 17

10.1002/bjs.18003815005
10.1136/thx.8.2.87
{'key': 'e_1_2_1_4_2', 'first-page': '209', 'article-title': "Barrett's oesophagus: congenital or acquired? An experimental study of esophageal mucosal regeneration in the dog", 'volume': '68', 'author': 'Bremner CG', 'year': '1970', 'journal-title': 'Surgery'} / Surgery / Barrett's oesophagus: congenital or acquired? An experimental study of esophageal mucosal regeneration in the dog by Bremner CG (1970)
10.1016/S0016-5085(66)80127-0
10.1016/S0016-5085(19)35323-5
10.1016/S0022-5223(19)39666-7 / J Thorac Cardio-vasc Surg / Columnar‐lined lower esophagus: an acquired lesion with malignant predisposition by Naef AP (1975)
10.7326/0003-4819-97-1-103
10.1016/S0016-5085(84)80012-8 / Gastroenterology / Barrett's esophagus; clinical, endoscopic, histologic, manometric, and electrical potential difference characteristics by Herlihy KJ (1984)
{'key': 'e_1_2_1_10_2', 'first-page': '431', 'article-title': 'Developmental changes in the oesophageal epithelium in man', 'volume': '86', 'author': 'Johns BAE.', 'year': '1952', 'journal-title': 'J Anat'} / J Anat / Developmental changes in the oesophageal epithelium in man by Johns BAE. (1952)
10.1056/NEJM197608262950904
10.1016/S0016-5085(19)32264-4
10.1001/archsurg.1984.01390170059012
10.1148/123.1.1
10.1136/gut.22.9.724
10.1001/archinte.140.4.475
10.1016/0016-5085(78)90771-0 / Gastroenterology / Cimetidine in the treatment of duodenal ulcer. Review and commentary by Winship DH. (1978)
10.1056/NEJM198306023082203
10.1016/0002-9343(83)90635-6
10.1097/00000658-198310000-00016
10.1056/NEJM198004103021506
10.1056/NEJM198008283030922
10.1016/0016-5085(84)90423-2 / Gastroenterology / Adenocarcinoma in Barrett's esophagus after elimination of gastroesophageal reflux by Hamilton SR (1984)
{'key': 'e_1_2_1_24_2', 'first-page': '78A', 'article-title': "Spectrum of carcinoma arising in Barrett's esophagus. A clinicopathologic study of twenty‐five patients", 'volume': '46', 'author': 'Smith RRL', 'year': '1982', 'journal-title': 'Lab Invest'} / Lab Invest / Spectrum of carcinoma arising in Barrett's esophagus. A clinicopathologic study of twenty‐five patients by Smith RRL (1982)
10.1016/S0016-5085(84)80016-5 / Gastroenterology / Clinical, epidemiologic, and morphologic comparison between adenocarcinomas arising in Barrett's esophageal mucosa and in the gastric cardia by Kalish RJ (1984)
{'key': 'e_1_2_1_26_2', 'first-page': '1236', 'article-title': "Dysplasia in Barrett's esophagus, (abstract)", 'volume': '86', 'author': 'Schmidt H.', 'year': '1984', 'journal-title': 'Gastroenterology'} / Gastroenterology / Dysplasia in Barrett's esophagus, (abstract) by Schmidt H. (1984)
10.1016/0016-5085(84)90090-8 / Gastroenterology / Adenocarcinoma and Barrett's esophagus. An overrated risk by Spechler SJ (1984)

Dates

Type	When
Created	17 years, 5 months ago (March 25, 2008, 7:18 a.m.)
Deposited	1 year, 10 months ago (Oct. 20, 2023, 10:15 a.m.)
Indexed	1 year, 8 months ago (Dec. 27, 2023, 1:30 p.m.)
Issued	39 years, 5 months ago (April 1, 1986)
Published	39 years, 5 months ago (April 1, 1986)
Published Online	17 years, 5 months ago (March 25, 2008)
Published Print	39 years, 5 months ago (April 1, 1986)

Funders 0

None

BibTeX

@article{KERLIN_1986, title={BARRETT’S ESOPHAGUS: CLINICAL, ENDOSCOPIC, AND HISTOLOGIC SPECTRUM IN FIFTY PATIENTS}, volume={16}, ISSN={0004-8291}, url={http://dx.doi.org/10.1111/j.1445-5994.1986.tb01148.x}, DOI={10.1111/j.1445-5994.1986.tb01148.x}, number={2}, journal={Australian and New Zealand Journal of Medicine}, publisher={Wiley}, author={KERLIN, P. and D’MELLOW, G. and VAN DETH, A.}, year={1986}, month=apr, pages={198–205} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2023,
        12,
        27
      ]
    ],
    "date-time": "2023-12-27T18:30:46Z",
    "timestamp": 1703701846205
  },
  "reference-count": 26,
  "publisher": "Wiley",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2008,
            3,
            25
          ]
        ],
        "date-time": "2008-03-25T00:00:00Z",
        "timestamp": 1206403200000
      },
      "content-version": "vor",
      "delay-in-days": 8029,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1986,
        4
      ]
    ]
  },
  "abstract": "<jats:p><jats:bold>Abstract</jats:bold> The columnar lined (Barrett's) esophagus is an acquired condition resulting from chronic gastroesophageal reflux. The clinical spectrum of 50 consecutive cases of endoscopically consistent, histologically proven Barrett's esophagus was reviewed. The mean age of patients was 65.9 \u00b1 12.4 (SD) years with only four patients younger than 50 years. The predominant presenting symptoms were dysphagia, heartburn, and regurgitation. At endoscopy, the columnar lined segment extended over 6.5 \u00b1 3.0 cm of the lower esophagus. Specialised columnar (intestinal) epithelium was the most frequent histological type identified. Radiologic or endoscopic evidence of a hiatal hernia was present in the majority. Complications were present at endoscopy in 38 (76%) patients. Reflux esophagitis (56%) was present at the area of the squamo\u2010columnar junction. Stricture formation (38%) and ulceration (36%) were located either at the squamo\u2010columnar junction or more distally within the columnar epithelium. Two patients (4%) had adenocarcinoma arising in a segment of Barrett's esophagus at presentation. Treatment included physical measures, dilatation, and cimetidine. Bougienage in 20 patients was successful in alleviating dysphagia but multiple treatment sessions were often necessary. Although esophagitis readily resolved with cimetidine therapy, ulceration was generally resistant to medical therapy. Indeed, by two months, healing was achieved in only five of 12 patients. Endoscopic surveillance of 12 patients who received cimetidine (1 g/day) for at least 12 months showed no regression of the metaplastic mucosa.</jats:p>",
  "DOI": "10.1111/j.1445-5994.1986.tb01148.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2008,
        3,
        25
      ]
    ],
    "date-time": "2008-03-25T11:18:09Z",
    "timestamp": 1206443889000
  },
  "page": "198-205",
  "source": "Crossref",
  "is-referenced-by-count": 17,
  "title": "BARRETT'S ESOPHAGUS: CLINICAL, ENDOSCOPIC, AND HISTOLOGIC SPECTRUM IN FIFTY PATIENTS",
  "prefix": "10.1111",
  "volume": "16",
  "author": [
    {
      "given": "P.",
      "family": "KERLIN",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "G.",
      "family": "D'MELLOW",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A.",
      "family": "VAN DETH",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2008,
        3,
        25
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/bjs.18003815005"
    },
    {
      "key": "e_1_2_1_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/thx.8.2.87"
    },
    {
      "key": "e_1_2_1_4_2",
      "first-page": "209",
      "article-title": "Barrett's oesophagus: congenital or acquired? An experimental study of esophageal mucosal regeneration in the dog",
      "volume": "68",
      "author": "Bremner CG",
      "year": "1970",
      "journal-title": "Surgery"
    },
    {
      "key": "e_1_2_1_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0016-5085(66)80127-0"
    },
    {
      "key": "e_1_2_1_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0016-5085(19)35323-5"
    },
    {
      "key": "e_1_2_1_7_2",
      "doi-asserted-by": "crossref",
      "first-page": "826",
      "DOI": "10.1016/S0022-5223(19)39666-7",
      "article-title": "Columnar\u2010lined lower esophagus: an acquired lesion with malignant predisposition",
      "volume": "70",
      "author": "Naef AP",
      "year": "1975",
      "journal-title": "J Thorac Cardio-vasc Surg"
    },
    {
      "key": "e_1_2_1_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.7326/0003-4819-97-1-103"
    },
    {
      "key": "e_1_2_1_9_2",
      "doi-asserted-by": "crossref",
      "first-page": "436",
      "DOI": "10.1016/S0016-5085(84)80012-8",
      "article-title": "Barrett's esophagus; clinical, endoscopic, histologic, manometric, and electrical potential difference characteristics",
      "volume": "86",
      "author": "Herlihy KJ",
      "year": "1984",
      "journal-title": "Gastroenterology"
    },
    {
      "key": "e_1_2_1_10_2",
      "first-page": "431",
      "article-title": "Developmental changes in the oesophageal epithelium in man",
      "volume": "86",
      "author": "Johns BAE.",
      "year": "1952",
      "journal-title": "J Anat"
    },
    {
      "key": "e_1_2_1_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1056/NEJM197608262950904"
    },
    {
      "key": "e_1_2_1_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0016-5085(19)32264-4"
    },
    {
      "key": "e_1_2_1_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1001/archsurg.1984.01390170059012"
    },
    {
      "key": "e_1_2_1_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1148/123.1.1"
    },
    {
      "key": "e_1_2_1_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/gut.22.9.724"
    },
    {
      "key": "e_1_2_1_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1001/archinte.140.4.475"
    },
    {
      "key": "e_1_2_1_17_2",
      "doi-asserted-by": "crossref",
      "first-page": "402",
      "DOI": "10.1016/0016-5085(78)90771-0",
      "article-title": "Cimetidine in the treatment of duodenal ulcer. Review and commentary",
      "volume": "74",
      "author": "Winship DH.",
      "year": "1978",
      "journal-title": "Gastroenterology"
    },
    {
      "key": "e_1_2_1_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1056/NEJM198306023082203"
    },
    {
      "key": "e_1_2_1_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0002-9343(83)90635-6"
    },
    {
      "key": "e_1_2_1_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00000658-198310000-00016"
    },
    {
      "key": "e_1_2_1_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1056/NEJM198004103021506"
    },
    {
      "key": "e_1_2_1_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1056/NEJM198008283030922"
    },
    {
      "key": "e_1_2_1_23_2",
      "doi-asserted-by": "crossref",
      "first-page": "356",
      "DOI": "10.1016/0016-5085(84)90423-2",
      "article-title": "Adenocarcinoma in Barrett's esophagus after elimination of gastroesophageal reflux",
      "volume": "86",
      "author": "Hamilton SR",
      "year": "1984",
      "journal-title": "Gastroenterology"
    },
    {
      "key": "e_1_2_1_24_2",
      "first-page": "78A",
      "article-title": "Spectrum of carcinoma arising in Barrett's esophagus. A clinicopathologic study of twenty\u2010five patients",
      "volume": "46",
      "author": "Smith RRL",
      "year": "1982",
      "journal-title": "Lab Invest"
    },
    {
      "key": "e_1_2_1_25_2",
      "doi-asserted-by": "crossref",
      "first-page": "461",
      "DOI": "10.1016/S0016-5085(84)80016-5",
      "article-title": "Clinical, epidemiologic, and morphologic comparison between adenocarcinomas arising in Barrett's esophageal mucosa and in the gastric cardia",
      "volume": "86",
      "author": "Kalish RJ",
      "year": "1984",
      "journal-title": "Gastroenterology"
    },
    {
      "key": "e_1_2_1_26_2",
      "first-page": "1236",
      "article-title": "Dysplasia in Barrett's esophagus, (abstract)",
      "volume": "86",
      "author": "Schmidt H.",
      "year": "1984",
      "journal-title": "Gastroenterology"
    },
    {
      "key": "e_1_2_1_27_2",
      "doi-asserted-by": "crossref",
      "first-page": "927",
      "DOI": "10.1016/0016-5085(84)90090-8",
      "article-title": "Adenocarcinoma and Barrett's esophagus. An overrated risk",
      "volume": "87",
      "author": "Spechler SJ",
      "year": "1984",
      "journal-title": "Gastroenterology"
    }
  ],
  "container-title": "Australian and New Zealand Journal of Medicine",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1445-5994.1986.tb01148.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1445-5994.1986.tb01148.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        20
      ]
    ],
    "date-time": "2023-10-20T14:15:23Z",
    "timestamp": 1697811323000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1111/j.1445-5994.1986.tb01148.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1986,
        4
      ]
    ]
  },
  "references-count": 26,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1986,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1445-5994.1986.tb01148.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1445-5994.1986.tb01148.x",
  "relation": {},
  "ISSN": [
    "0004-8291"
  ],
  "subject": [],
  "container-title-short": "Australian and New Zealand Journal of Medicine",
  "published": {
    "date-parts": [
      [
        1986,
        4
      ]
    ]
  }
}