DOI: 10.1111/j.1445-5994.1980.tb03421.x. Apparent Insulin Resistance due to Abnormal Enzymatic Insulin Degradation: A New Mechanism for Insulin Resistance

Apparent Insulin Resistance due to Abnormal Enzymatic Insulin Degradation: A New Mechanism for Insulin Resistance

10.1111/j.1445-5994.1980.tb03421.x

Crossref journal-article

Wiley

Australian and New Zealand Journal of Medicine (311)

Abstract

Summary: Apparent insulin resistance due to abnormal enzymatic insulin degradation: A new mechanism for insulin resistance. A. McElduff, C. J. Eastman, S. P. Haynes and K. M. Bowen. Aust. N.Z. J. Med., 1980, 10, pp. 56–61.A 16–year‐old girl presented with severe, prolonged insulin resistance. Insulin antibodies, initially thought to be responsible for the insulin resistance, were suppressed using monocomponent insulin and immunosuppressive therapy; however insulin resistance persisted. Insulin kinetic studies suggested abnormal metabolism of a bolus injection of 125insulin and the reappearance in the circulation of radioactive products, demonstrated by chromatography to be of different molecular weight to insulin. These products were of similar molecular weight to material obtained by incubating125/insulin with protease. Trasylol significantly reduced the patient's insulin requirements and normalised the disappearance of125/ insulin from the circulation. Prolonged treatment with Trasylol resulted in a fall in insulin requirement to non “insulin resistance” levels. The insulin requirement remained static when Trasylol was ceased. We propose abnormally rapid insulin degradation to be a new mechanism of resistance to insulin therapy.

Bibliography

McElduff, A., Eastman, C. J., Haynes, S. P., & Bowen, K. M. (1980). Apparent Insulin Resistance due to Abnormal Enzymatic Insulin Degradation: A New Mechanism for Insulin Resistance. Australian and New Zealand Journal of Medicine, 10(1), 56â61. Portico.

Authors 4

A. McElduff (first)
C. J. Eastman (additional)
S. P. Haynes (additional)
K. M. Bowen (additional)

References 28 Referenced 20

10.1056/NEJM192908012010501
10.1210/jcem-1-5-387
10.1146/annurev.me.13.020162.001341
{'key': 'e_1_2_1_5_2', 'first-page': '75', 'article-title': 'Insulin resistance', 'volume': '8', 'author': 'Smelo L. S.', 'year': '1948', 'journal-title': 'Prne. Amer. Diah. Assoc'} / Prne. Amer. Diah. Assoc / Insulin resistance by Smelo L. S. (1948)
10.1136/bmj.2.4895.1022
{'key': 'e_1_2_1_7_2', 'first-page': '125', 'volume-title': "Joshn's Diabetes. Mellitus", 'author': 'Soeldner J. S.', 'year': '1971'} / Joshn's Diabetes. Mellitus by Soeldner J. S. (1971)
{'key': 'e_1_2_1_8_2', 'first-page': '3658', 'article-title': 'Insulin inhibitors and insulin resistance', 'volume': '60', 'author': 'Berson S. A.', 'year': '1960', 'journal-title': 'N.Y. St. J. Med'} / N.Y. St. J. Med / Insulin inhibitors and insulin resistance by Berson S. A. (1960)
10.1172/JCI103435
{'key': 'e_1_2_1_10_2', 'first-page': '85', 'article-title': 'Insulin allergy and insulin resistance', 'volume': '63', 'author': 'Shazo R. D.', 'year': '1918', 'journal-title': 'Postgrad. Med'} / Postgrad. Med / Insulin allergy and insulin resistance by Shazo R. D. (1918)
10.1016/0002-9343(77)90155-3
10.2337/diab.6.5.402
10.1056/NEJM197604012941401
10.1056/NEJM197702032960503
{'key': 'e_1_2_1_15_2', 'first-page': '63', 'article-title': 'The clinical significance of insulin antibodies', 'volume': '270', 'author': 'Axdersey O. O.', 'year': '1971', 'journal-title': 'Acta poediat. sand'} / Acta poediat. sand / The clinical significance of insulin antibodies by Axdersey O. O. (1971)
{'key': 'e_1_2_1_16_2', 'first-page': '145', 'article-title': 'Determination of farce and antibody bound insulin in insulin treated diabetic patients', 'volume': '3', 'author': 'Hecling L.', 'year': '1969', 'journal-title': 'Horm. Metab. Res'} / Horm. Metab. Res / Determination of farce and antibody bound insulin in insulin treated diabetic patients by Hecling L. (1969)
10.1016/0026-0495(78)90121-X
10.1038/194495a0
{'key': 'e_1_2_1_19_2', 'first-page': '223', 'volume-title': 'Peptide Hormones', 'author': 'Roth J.', 'year': '1915'} / Peptide Hormones by Roth J. (1915)
10.1016/0304-4165(66)90498-3
10.1172/JCI103262
10.1172/JCI108918
10.1001/archinte.137.4.474
{'key': 'e_1_2_1_24_2', 'first-page': '95', 'article-title': 'Receptors for insulin. NSILA‐s. and growth hormone: Applications to disease states in man', 'volume': '31', 'author': 'Roth J.', 'year': '1975', 'journal-title': 'Recent Progr. Hormone Res'} / Recent Progr. Hormone Res / Receptors for insulin. NSILA‐s. and growth hormone: Applications to disease states in man by Roth J. (1975)
10.2337/diab.24.6.566 / Diabetes / Degradation of insulin by isolated rat liver cells by Le Cam A. (1975)
{'key': 'e_1_2_1_26_2', 'first-page': '334', 'article-title': 'An insulin‐degrading enzyme in a diabetic girl causing massive destruction of subcutaneous insulin', 'volume': '25', 'author': 'Paulsen E. P.', 'year': '1976', 'journal-title': 'Diabetes'} / Diabetes / An insulin‐degrading enzyme in a diabetic girl causing massive destruction of subcutaneous insulin by Paulsen E. P. (1976)
10.1016/S0021-9258(18)97306-0 / J. biol. Chem / Glutathione‐insulin transhydrogenase of human liver by Tomizawa H. H. (1965)
10.2337/diab.18.3.176
10.1016/S0021-9258(19)45126-0 / J. biol. Chem / Insulin interaction with liver membranes. Independence of binding ssof hormone and its degradation by Freychet P. (1972)

Dates

Type	When
Created	17 years, 5 months ago (March 25, 2008, 8:45 a.m.)
Deposited	1 year, 9 months ago (Nov. 9, 2023, 6:42 p.m.)
Indexed	1 day, 12 hours ago (Sept. 4, 2025, 9:42 a.m.)
Issued	45 years, 7 months ago (Feb. 1, 1980)
Published	45 years, 7 months ago (Feb. 1, 1980)
Published Online	17 years, 5 months ago (March 25, 2008)
Published Print	45 years, 7 months ago (Feb. 1, 1980)

Funders 0

None

BibTeX

@article{McElduff_1980, title={Apparent Insulin Resistance due to Abnormal Enzymatic Insulin Degradation: A New Mechanism for Insulin Resistance}, volume={10}, ISSN={0004-8291}, url={http://dx.doi.org/10.1111/j.1445-5994.1980.tb03421.x}, DOI={10.1111/j.1445-5994.1980.tb03421.x}, number={1}, journal={Australian and New Zealand Journal of Medicine}, publisher={Wiley}, author={McElduff, A. and Eastman, C. J. and Haynes, S. P. and Bowen, K. M.}, year={1980}, month=feb, pages={56–61} }

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